Neuroprotection par l’activation des sirtuines dans des modèles simplifiés de chorée de Huntington

Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of Sirt1 in hippocampus

“…Sirt1 is a member of sirtuin famlily encoding NAD + -dependent deacetylases [ 40 ]. Numerous studies have documented that Sirt1 mediates the neuroprotective effects of resveratrol in neurodegenerative disease, such as Huntington disease [ 41 ]. Interestingly, our previous work demonstrated that H 2 S increases the expression of Sirt1 protein in hippocampus of rats [ 26 ].…”

Cerebellar Predominant Increase in mRNA Expression Levels of Sirt1 and Sirt3 Isoforms in a Transgenic Mouse Model of Huntington’s Disease

“…Besides the somewhat inconsistent findings obtained from the abovementioned studies, the experiments influencing the expression of SIRT1 or of its orthologues from a therapeutic point of view yielded more controversial results. Parker et al were the first who demonstrated that Sir2 overexpression and resveratrol (RESV) treatment (one of the most important non-selective Sirtuin inducer) could delay the development of neuronal dysfunction in a Caenorhabditis elegans model of HD (Htt N-terminal fragment, 128Q) in vivo [42]. They also reported that RESV prevented the striatal neuronal cell death in HdhQ111 knock-in mice [42].…”

“…Parker et al were the first who demonstrated that Sir2 overexpression and resveratrol (RESV) treatment (one of the most important non-selective Sirtuin inducer) could delay the development of neuronal dysfunction in a Caenorhabditis elegans model of HD (Htt N-terminal fragment, 128Q) in vivo [42]. They also reported that RESV prevented the striatal neuronal cell death in HdhQ111 knock-in mice [42]. To test the potential neuroprotective effect of SIRT1, Jeong et al crossed a brainspecific Sirt1 knockout mice (BSKO; genotype: Sirt1 flox/flox ) with the R6/2 HD model mice [22].…”