Neuroprotection of low-molecular-weight galactan obtained from Cantharellus cibarius Fr. against Alzheimer's disease

Intervention effects of low-molecular-weight chondroitin sulfate from the nasal cartilage of yellow cattle on lipopolysaccharide-induced behavioral disorders: regulation of the microbiome-gut-brain axis

“…(chanterelle) and reduced its molecular weight from approximately 20 kDa to 5 kDa (named CCP) to increase its solubility and absorption. In APP/PS1 mice, CCP improved both spatial and non-spatial memory loss in AD mice, as confirmed by the Morris water maze, step-down, step-through, and novel object recognition tests, and dampened the deposition of amyloid-β plaques ( 42 ). In this study, CS-1 and CS-2 obtained from the H 2 O 2 -Vc degradation system showed no significant changes in the sulfate and uronic acid contents of the extracted CS.…”

Insights into chemical components, health-promoting effects, and processing impact of golden chanterelle mushroom Cantharellus cibarius

“…Moreover, a variety of galactans were also isolated from the fruiting body of CC. A low-molecular-weight (1,6)-linked α- d -galactan (CCP 1 ) consisting of galactose (73.40%), methylgalactose (18.40%), mannose (4.80%), and glucose (3.40%) was isolated by Zhou et al 72 The isolation process involved hot water extraction, ethanol precipitation, and column chromatography purification to obtain WCCP-N with a molecular weight of 20 kDa. After that, the purified WCCP-N polysaccharide underwent slight hydrolysis, reducing its molecular weight to 5 kDa, resulting in CCP 1 .…”

“…After that, the purified WCCP-N polysaccharide underwent slight hydrolysis, reducing its molecular weight to 5 kDa, resulting in CCP 1 . 72 A (1,6)-linked α- d -galactan called WCCP-N-b was isolated and purified by Yang et al 73 from the CC fruiting body using the same extraction method as that used for WCCP-N. It had a molecular weight of 18 kDa and was composed of galactose, 3-methylgalactose, glucose, and mannose in a molar ratio of 14.4 : 4.6 : 1.0 : 1.2.…”

“…A study conducted by Zhou et al 72 demonstrated that the CCP 1 polysaccharide isolated from CC effectively alleviated the symptoms of Alzheimer's disease (AD) in mice model. Primarily, behavioral tests, including the Morris water maze (MWM), step-down test (SDT), step-through test (STT), and novel object recognition (NOR), all indicated that CCP 1 could enhance learning ability and alleviate memory loss in APP/PS1 mice.…”

“…Additionally, it also decreased the release of pro-inflammatory cytokines (IL-1β, IL-6, iNOS, and TNF-α) and increased the release of anti-inflammatory cytokine (IL-4). 72…”