Neuroprotection of Cilostazol against ischemia/reperfusion-induced cognitive deficits through inhibiting JNK3/caspase-3 by enhancing Akt1

Qi, Dashi; Tao, Jinhao; Zhang, Lian-Qin; Li, Man; Wang, Mei; Rui, Qu; Zhang, Shichun; Liu, Pei; Liu, Fuming; Miu, Jian-Cheng; Ma, Jingyi; Mei, Xinyu; Zhang, Fayong

doi:10.1016/j.brainres.2016.10.017

Cited by 35 publications

(21 citation statements)

References 38 publications

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“…contributing to its oncogenic potential. through many signalling pathways including PI3K (Wang et al, ), ERK1/2 (Li et al, ) and JNK (Qi et al, ). However, the interaction between miR‐149‐3P and Akt1 had not been confirmed in pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Potent effects of dioscin against pancreatic cancer via miR‐149‐3P‐mediated inhibition of the Akt1 signalling pathway

Yin

et al. 2017

British J Pharmacology

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Section: Discussionmentioning

confidence: 99%

Potent effects of dioscin against pancreatic cancer via miR‐149‐3P‐mediated inhibition of the Akt1 signalling pathway

Yin

et al. 2017

British J Pharmacology

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“…BNG-1 can also inhibit several phosphodiesterase (PDE) isoforms 20 with potency order of the following rank: PDE1 > PDE7A > PDE3 > PDE6 > PDE2 > PDE4 > PDE5. A potent PDE3 inhibitor, cilostazol 37–39 , is used clinically as an anti-platelet drug to treat ischemic stroke 40, 41 . Intravenous administration of cilostazol nanoparticles was found to ameliorates acute ischemic stroke in cerebral ischemia/reperfusion-induced injury after middle cerebral artery occlusion in mice 42 .…”

Section: Discussionmentioning

confidence: 99%

Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat

Lee

Yeh

Tsai

et al. 2017

Sci Rep

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Combination therapy with focused ultrasound (FUS) and a neuroprotective agent, BNG-1, was examined in an acute carotid thrombotic occlusion model using LED irradiation in rat to improve the thrombolytic effect of rt-PA. Seven treatment groups included (A) intravenous bolus injection of 0.45 mg/kg rt-PA, (B) intravenous bolus injection of 0.9 mg/kg, (C) sonothrombolysis with FUS alone, (D) oral administration of 2 g/kg BNG-1 for 7 days alone, (E) A + D, (F) A + C, and (G) A + C + D. Four comparison groups were made including (H) 0.45 mg/kg rt-PA 20% bolus +80% IV fusion + FUS, (I) 0.9 mg/kg rt-PA with 10% bolus + 90% intravenous fusion, (J) B + C, (K) B + D. At 7 days after carotid occlusion, small-animal carotid ultrasound and 7 T MR angiography showed the recanalization rate of ≤50% stenosis was 50% in group B and 83% in group I, but 0% in groups A and C and 17% in group D. Combination therapy improved recanalization rate to 50–63% in groups E and F, to 67–83% in groups J and K, and to 100% in groups G and H. Our study demonstrated combination therapy with different remedies can be a feasible strategy to improve the thrombolytic effect of rt-PA.

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“…As a primary cause of paralysis and death around the world, ischemic stroke and the accompanying reperfusion injury are widely known for such complications as hemiplegia, coma, and even death. Although new and advanced tools and medications are available for earlier diagnosis and treatment, such as magnetic resonance imaging (MRI) technology [ 1 , 2 ], high morbidity and mortality still constitute the most disturbing prognosis of this vascular disease. Many pathological changes happen during the obstinate illness, including cell death (necrosis and apoptosis), angiogenesis, inflammation, and cerebral edema [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture at GV20 and ST36 Exerts Neuroprotective Effects via the EPO‐Mediated JAK2/STAT3 Pathway in Cerebral Ischemic Rats

Zhang

Sun

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Background While electroacupuncture (EA) in cerebral ischemia has been used to promote functional recovery, the underlying mechanism of its protective effect remains poorly understood. Objective We investigated the effects of EA stimulation at GV20 and ST36 to observe the changes in erythropoietin- (EPO-) mediated Janus family tyrosine kinases 2 (JAK2) signal transducers and activators of the transcription 3 (STAT3) cell pathway. Methods Thirty-six specific pathogen-free Sprague-Dawley (SD) male rats were randomly assigned to three groups: the sham-operated group (S group), the middle cerebral artery occlusion (MCAO) group (M group), and the EA group. Neurological deficits were assessed through the Ludmila Belayev 12-score test and 2,3,5-triphenyltetrazolium chloride (TTC) staining was shown. The protein and mRNA expression levels of EPO, the EPO receptor (EpoR), p-JAK2, JAK2, p-STAT3, and STAT3 were examined to explore the EA effect on rats with cerebral ischemic reperfusion injury (CIRI). Results EA significantly decreased infarct size and improved neurological function. Furthermore, target EPO, EpoR, JAK2, and STAT3 mRNA and protein levels significantly increased in the EA group. Conclusions EA exerts a neuroprotective effect, possibly via the regulation of the EPO-mediated JAK2/STAT3 cell pathway and downstream apoptotic pathways in a rat CIRI model.

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Neuroprotection of Cilostazol against ischemia/reperfusion-induced cognitive deficits through inhibiting JNK3/caspase-3 by enhancing Akt1

Cited by 35 publications

References 38 publications

Potent effects of dioscin against pancreatic cancer via miR‐149‐3P‐mediated inhibition of the Akt1 signalling pathway

Potent effects of dioscin against pancreatic cancer via miR‐149‐3P‐mediated inhibition of the Akt1 signalling pathway

Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat

Electroacupuncture at GV20 and ST36 Exerts Neuroprotective Effects via the EPO‐Mediated JAK2/STAT3 Pathway in Cerebral Ischemic Rats

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