Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia

Impairment in Long-Term Memory Formation and Learning-Dependent Synaptic Plasticity in Mice Lacking Glycogen Synthase in the Brain

“…Importantly, we performed electrophysiologic studies in alert, behaving animals, following procedures developed by some of us. 14,15,22 Our results show that pairedpulse facilitation, a well-characterized form of short-term plasticity related to short-term memory processes, is in fact enhanced in GYS1 Nestin-KO mice. Paired-pulse stimulation is frequently used as an indirect measurement of changes in the probability of neurotransmitter release at the presynaptic terminal.…”

Antioxidant activity ofCitrus limonessential oil in mouse hippocampus

“…Most of the studies with EO were carried out in organs and systems other than the CNS (Viana et al, 2000;Gottlieb et al, 2006). In the present work, lipid peroxidation level, nitrite content, GSH concentration, and antioxidant enzymes were determined in mice hippocampus, after the EO of C. limon administration.…”

Mangiferin Ameliorates Scopolamine-Induced Learning Deficits in Mice

“…[21][22][23][24] Mangiferin also rescues neurons from cell death in acute injury and reduces neurological deficits caused by ischemic damage to the brain. 25) These findings suggest that scopolamine may cause cholinergic neuron injury and inflammation in the brain and that mangiferin may improve memory deficits by acetylcholine esterase inhibition or cholinergic receptor stimulation and inhibition of NF-kB activation. Finally we suggest that AA and its main constituent, mangiferin, can improve long-term cholinergic memory deficits.…”