Mangiferin Ameliorates Scopolamine-Induced Learning Deficits in Mice

Jung, Kangsik; Lee, Bomi; Han, Sang Jun; Ryu, Jong Hoon; Kim, Dong-Hyun

doi:10.1248/bpb.32.242

Cited by 67 publications

(41 citation statements)

References 23 publications

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“…Chlorogenic acid inhibited carrageenan-induced paw edema and formalin-induced pain in rats in vivo (dos Santos et al, 2006). Mangiferin, which has strong anti-inflammatory properties, is a major active constituent of Anemarrhena asphodeloides BUNGE (Jung et al, 2009). It has been known that mangiferin inhibited LPS-induced nitric oxide and prostaglandin E 2 through NF-B inactivation in RAW 264.7 macrophages and rat microglial cells, which exhibits antiinflammatory effect in vitro (Bhatia et al, 2008;Garrido et al, 2004a,b).…”

Section: Discussionmentioning

confidence: 99%

“…It is known that AA contains various compounds (see Table 2). AA primarily contains mangiferin and steroidal saponins such as sarsasapogenin and timosaponin AII and BII (Jung et al, 2009). The present study was conducted in rodents to investigate the analgesic and anti-inflammatory activities of WIN-34B for treatment of osteoarthritis by comparing its activities with that of commonly used anti-osteoarthritic drugs, including Joins TM , celecoxib or indomethacin.…”

Section: Introductionmentioning

confidence: 99%

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The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo

Kang

Jung

Hur

et al. 2010

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo

Kang

Jung

Hur

et al. 2010

Journal of Ethnopharmacology

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“…It is known that the expression of COX-2 and the synthesis of prostaglandin E2 (PGE2), one of its products, are increased in the hippocampus of AD patients, which may be related to the pathogenesis of the degenerative changes and cognitive impairments [44]. These results suggest that inflammatory responses to SCO injection significantly stimulated the expression of COX-2 mRNA in the hippocampus through modulating the NF-κB pathway [45]. The increase in COX-2 expression by NF-κB activation can accelerate inflammatory responses and subsequently contribute to learning and memory deficits.…”

Section: Discussionmentioning

confidence: 99%

Phellodendron amurenseand Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats

Lee

Sur

Shim

et al. 2012

Korean J Physiol Pharmacol

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We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic system and pro-inflammatory cytokines in the hippocampus were also investigated. Male rats were administered daily doses for 14 days of PA (100 and 200 mg/kg, i.p.) and BER (20 mg/kg, i.p.) 30 min before scopolamine injection (2 mg/kg, i.p.). Daily administration of PA and BER improved memory impairment as measured by the passive avoidance test and reduced the escape latency for finding the platform in the Morris water maze test. Administration of PA and BER significantly alleviated memory-associated decreases in cholinergic immunoreactivity and restored brain-derived neurotrophic factor and cAMP-response element-binding protein mRNA expression in the hippocampus. PA and BER also decreased significantly the expression of proinflammatory cytokines such as interleukin-1β, tumor necrosis factor-α and cyclooxygenase-2 mRNA in the hippocampus. These results demonstrated that PA and BER had significant neuroprotective effects against neuronal impairment and memory dysfunction caused by scopolamine in rats. These results suggest that PA and BER may be useful as therapeutic agents for improving cognitive functioning by stimulating cholinergic enzyme activity and alleviating inflammatory responses.

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“…Significant reduction had been seen in TNF-α (tumor necrosis factor) levels tempted by inhibited nuclear factor-kappa-B stimulation in scopolamine in mice brain or TNF stimulated cells by using mangiferin (20 mg/kg). Additionally, mangiferin enhances the deficits of long-term cholinergic-memory by inhibiting stimulation of cholinergic receptor and NF-κB activation suppression [113]. …”

Section: Miscellaneous Propertiesmentioning

confidence: 99%

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

et al. 2017

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The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.

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Mangiferin Ameliorates Scopolamine-Induced Learning Deficits in Mice

Cited by 67 publications

References 23 publications

The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo

The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo

Phellodendron amurenseand Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

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