Neuroprotectin D1, a lipid anti-inflammatory mediator, in patients with intracerebral hemorrhage

Lipids are biological molecules that play vital roles in all living organisms. They perform many cellular functions, such as 1) forming cellular and subcellular membranes, 2) storing and using energy, and 3) serving as chemical messengers during intra‐ and inter‐cellular signal transduction. The large‐scale study of the pathways and networks of cellular lipids in biological systems is called “lipidomics” and is one of the fastest‐growing omics technologies of the last two decades. With state‐of‐the‐art mass spectrometry instrumentation and sophisticated data handling, clinical studies show how human lipid composition changes in health and disease, thereby making it a valuable medium to collect for clinical applications, such as disease diagnostics, therapeutic decision‐making, and drug development. This review gives a comprehensive overview of current workflows used in clinical research, from sample collection and preparation to data and clinical interpretations. This is followed by an appraisal of applications in 2022 and a perspective on the exciting future of clinical lipidomics.

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“…Bibliometric analyses of clinical lipidomics publications in 2022 according to separation techniques, detectors, and RPLC columns used …”

Section: In Review: Materials and Methodsmentioning

confidence: 99%

“…Bibliometric analyses of clinical lipidomics publications in 2022 using Scopus search terms “lipidomics” AND “clinic*” on 15 th December 2022 …”

Section: In Review: Materials and Methodsmentioning

confidence: 99%

Chewing the fat: How lipidomics is changing our understanding of human health and disease in 2022

Géhin

Fowler

Trivedi

2023

Analytical Science Advances

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“…In rats, supplementing with LPC-DHA normalized brain levels of LPC-DHA and alleviated neuronal cell death, activation of astrocytes, and expression of various inflammatory and mitochondrial dynamics genes [59]. Another study observed that acute brain injury (intracerebral hemorrhage) triggers the synthesis of neuroprotectin D1, a DHAderived SPM: neuroprotectin D1 levels were higher in patients with better 90-day outcome [60]. Neuroprotectin D1 is synthesized from DHA via 15-lipoxygenase and the gene encoding this enzyme was almost undetectable in patients with modified Rankin score 4-6 and worse outcome.…”

Section: Omega-3 Polyunsaturated Fatty Acids Brain Injury and Neurolo...mentioning

confidence: 98%

“…Neuroprotectin D1 is synthesized from DHA via 15-lipoxygenase and the gene encoding this enzyme was almost undetectable in patients with modified Rankin score 4-6 and worse outcome. The authors suggest that early synthesis and abundance of neuroprotectin D1 is likely an important protective factor [60].…”

Section: Omega-3 Polyunsaturated Fatty Acids Brain Injury and Neurolo...mentioning

confidence: 99%

The role of omega-3 polyunsaturated fatty acids in the intensive care unit

Singer¹,

Calder

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewThis review provides an update on the actions of omega-3 polyunsaturated fatty acids (PUFAs) and presents the most recent findings from trials in patients in the intensive care unit (ICU) setting including relevant meta-analyses. Many specialized pro-resolving mediators (SPMs) are produced from bioactive omega-3 PUFAs and may explain many of the beneficial effects of omega-3 PUFAs, although other mechanisms of action of omega-3 PUFAs are being uncovered. Recent findingsSPMs resolve inflammation, promote healing and support antiinfection activities of the immune system. Since publication of the ESPEN guidelines, numerous studies further support the use of omega-3 PUFAs. Recent meta-analyses favor the inclusion of omega-3 PUFAs in nutrition support of patients with acute respiratory distress syndrome or sepsis. Recent trials indicate that omega-3 PUFAs may protect against delirium and liver dysfunction in patients in the ICU, although effects on muscle loss are unclear and require further investigation. Critical illness may alter omega-3 PUFA turnover. There has been significant discussion about the potential for omega-3 PUFAs and SPMs in treatment of coronavirus disease 2019.

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Sample pretreatment and analytical methodology for the determination of antibiotics in swine wastewater and activated sludge

Yuan

et al. 2022

Environ Sci Pollut Res

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Neuroprotectin D1, a lipid anti-inflammatory mediator, in patients with intracerebral hemorrhage

Cited by 4 publications

References 9 publications

Chewing the fat: How lipidomics is changing our understanding of human health and disease in 2022

Chewing the fat: How lipidomics is changing our understanding of human health and disease in 2022

The role of omega-3 polyunsaturated fatty acids in the intensive care unit

Sample pretreatment and analytical methodology for the determination of antibiotics in swine wastewater and activated sludge

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