Neuroplasticity of face sensorimotor cortex and implications for control of orofacial movements

Avivi‐Arber, Limor; Lee, Jye-Chang; Yao, Dongyuan; Adachi, Kazunori; Sessle, Barry J.

doi:10.1016/j.jdsr.2009.11.007

Cited by 8 publications

(6 citation statements)

References 119 publications

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“…The cortical neuroplastic mechanisms and processes underlying orofacial sensory and motor functions may be important for the development of new therapeutic strategies to facilitate the recovery of patients with orofacial pain and sensorimotor disorders, as well as to improve their quality of life [30]. The results of the present study support the development of interventions for early identification and treatment This study has some limitations that should be considered.…”

Section: Discussionmentioning

confidence: 63%

Swallowing impairment in older adults: association with sensorimotor peripheral nerve function from the Health, Aging and Body Composition study

et al. 2020

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Background The purpose of this study was to examine whether impairments in sensorimotor peripheral nerve function are associated with a higher likelihood of swallowing impairment in older adults. Methods Health, Aging and Body Composition participants (n = 607, age = 75.8 ± 2.7 years, 55.8% women, 32.3% black) underwent peripheral nerve testing at Year 4 and 11 with swallowing difficulty assessed at Year 4 and 15. Nerve conduction amplitude and velocity were measured at the peroneal motor nerve. Sensory nerve function was assessed with the vibration detection threshold and monofilament (1.4-g/10-g) testing at the big toe. Symptoms of lower extremity peripheral neuropathy and difficulty swallowing were collected by self-report. Data analysis was performed using a hierarchical approach. Odds ratios (ORs) were estimated using non-conditional logistic regression. Results At Year 15 108 (17.8%) participants had swallowing impairments. In fully adjusted models, the peripheral nerve impairments associated with swallowing impairment were numbness (OR 4.67; 95%CI 2.24-9.75) and poor motor nerve conduction velocity (OR 2.26;. Other peripheral nerve impairments were not related to swallowing. Conclusions The association between slow motor nerve conduction velocity and numbness and a higher likelihood of swallowing difficulties a decade later in our prospective study identifies an important area for further investigation in older adults.

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Section: Discussionmentioning

confidence: 63%

Swallowing impairment in older adults: association with sensorimotor peripheral nerve function from the Health, Aging and Body Composition study

et al. 2020

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“…The progressively attenuated activity in the left sensorimotor area indicates that dysfunction in the facial nerve has devastating effects on the contralateral sensorimotor area. 7 , 8 Curve fitting (Fig. 5 B) between Z value in the right sensorimotor area in the lip-pursing task results and intervals of facial nerve injury revealed that the activation in the right sensorimotor area was reduced in early stage of facial dysfunction (ie, less than 6 mos, Fig.…”

Section: Discussionmentioning

confidence: 95%

“…In previous studies, it has been found that lesions in peripheral motor nerves could lead to central cortical reorganization. 7 – 10 The area mostly associated with facial movement is located in the primary sensorimotor area. 11 , 12 Previous studies have emphasized this area has dynamic and adaptive mechanisms that mediate motor and cognitive integration in learning and memory.…”

Section: Introductionmentioning

confidence: 99%

Time-course of Changes in Activation Among Facial Nerve Injury

et al. 2015

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Patients suffering different intervals of facial nerve injury were investigated by functional magnetic resonance imaging to study changes in activation within cortex.Forty-five patients were divided into 3 groups based on intervals of facial nerve injury. Another 16 age and sex-matched healthy participants were included as a control group. Patients and healthy participants underwent task functional magnetic resonance imaging (eye blinking and lip pursing) examination.Functional reorganization after facial nerve injury is dynamic and time-dependent. Correlation between activation in sensorimotor area and intervals of facial nerve injury was significant, with a Pearson correlation coefficient of −0.951 (P < 0.001) in the left sensorimotor area and a Pearson correlation coefficient of 0.333 (P = 0.025) in the right sensorimotor area.Increased activation in integration areas, such as supramarginal gyrus and precunes lobe, could be detected in the early-middle stage of facial dysfunction compared with normal individuals. Decreased activation in sensorimotor area contralateral to facial nerve injury could be found in late stage of facial dysfunction compared with normal individuals. Dysfunction in the facial nerve has devastating effects on the activity of sensorimotor areas, whereas enhanced intensity in the sensorimotor area ipsilateral to the facial nerve injury in middle stage of facial dysfunction suggests the possible involvement of interhemispheric reorganization. Behavioral or brain stimulation technique treatment in this stage could be applied to alter reorganization within sensorimotor area in the rehabilitation of facial function, monitoring of therapeutic efficacy, and improvement in therapeutic intervention along the course of recovery.

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“…The altered development of FC in individuals with PAE may underlay their altered cognitive‐motor development (Adnams et al, ). Furthermore, due to the high neuroplasticity of facial sensorimotor function (Avivi‐Arber, Lee, Yao, Adachi, & Sessle, ; Avivi‐Arber, Martin, Lee, & Sessle, ), this FC might be an potential biomarker to evaluate brain development and interventions to improve sensorimotor function in the FASD population.…”

Section: Discussionmentioning

confidence: 99%

Sensorimotor network alterations in children and youth with prenatal alcohol exposure

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Beaulieu

et al. 2018

Human Brain Mapping

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Children with prenatal alcohol exposure (PAE) often have impaired sensorimotor function. While altered brain structure has been noted in sensorimotor areas, the functional brain alterations remain unclear. This study aims to investigate sensorimotor brain networks in children and youth with PAE using resting-state functional magnetic resonance imaging (rs-fMRI). A parcellation-based network analysis was performed to identify brain networks related to hand/lower limb and face/upper limb function in 59 children and youth with PAE and 50 typically developing controls. Participants with PAE and controls had similar organization of the hand and face areas within the primary sensorimotor cortex, but participants with PAE had altered functional connectivity (FC) between the sensorimotor regions and the rest of the brain. The sensorimotor regions in the PAE group showed less connectivity to certain hubs of the default mode network and more connectivity to areas of the salience network. Overall, our results show that despite similar patterns of organization in the sensorimotor network, subjects with PAE have increased FC between this network and other brain areas, perhaps suggesting overcompensation. These alterations in the sensorimotor network lay the foundation for future studies to evaluate interventions and treatments to improve motor function in children with PAE.

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Neuroplasticity of face sensorimotor cortex and implications for control of orofacial movements

Cited by 8 publications

References 119 publications

Swallowing impairment in older adults: association with sensorimotor peripheral nerve function from the Health, Aging and Body Composition study

Swallowing impairment in older adults: association with sensorimotor peripheral nerve function from the Health, Aging and Body Composition study

Time-course of Changes in Activation Among Facial Nerve Injury

Sensorimotor network alterations in children and youth with prenatal alcohol exposure

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