Neurophysiology tools to lower the stroke onset to treatment time during the golden hour: microwaves, bioelectrical impedance and near infrared spectroscopy

Biase, Lazzaro di; Bonura, Adriano; Caminiti, Maria Letizia; Pecoraro, Pasquale Maria; Lazzaro, Vincenzo Di

doi:10.1080/07853890.2022.2124448

Cited by 4 publications

(3 citation statements)

References 89 publications

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“…While treatment modalities for stroke have evolved from leeches in the medieval ages to advanced thrombectomy interventions, early detection remains behind, relying mainly on clinical observation. Emphasis has been on implementing methodologies for prompt stroke management in the hospital setting (1). Yet only 15-32% of patients presenting with treatable ischemic stroke arrive in time (2).…”

Section: Pastmentioning

confidence: 99%

Pre-hospital stroke monitoring past, present, and future: a perspective

Ben Pazi,

Jahashan,

Har Nof

et al. 2024

Front. Neurol.

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Integrated brain-machine interface signifies a transformative advancement in neurological monitoring and intervention modalities for events such as stroke, the leading cause of disability. Historically, stroke management relied on clinical evaluation and imaging. While today’s stroke landscape integrates artificial intelligence for proactive clinical decision-making, mainly in imaging and stroke detection, it depends on clinical observation for early detection. Cardiovascular monitoring and detection systems, which have become standard throughout healthcare and wellness settings, provide a model for future cerebrovascular monitoring and detection. This commentary reviews the progression of continuous stroke monitoring, spotlighting contemporary innovations and prospective avenues, and emphasizes the influential roles of cutting-edge technologies in shaping stroke care.

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Section: Pastmentioning

confidence: 99%

Pre-hospital stroke monitoring past, present, and future: a perspective

Ben Pazi,

Jahashan,

Har Nof

et al. 2024

Front. Neurol.

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“… 15 Other research takes advantage of microwave scattering and imaging, near-infrared spectroscopy, bioelectrical impedance spectroscopy in an effort to reduce time to treatment for stroke patients. 16 , 17 Medfields MD 100 Strokefinder is a microwave technology-based implementation, intended for measuring dielectric properties of brain tissue. The purpose of the measurement is to provide information regarding the presence of stroke.…”

Section: Introductionmentioning

confidence: 99%

Detecting Stroke at the Emergency Department by a Point of Care Device: A Multicenter Feasibility Study

Tsiftsis,

Manioti,

Touris

et al. 2024

MDER

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Purpose To evaluate if the Strokefinder MD 100 by Medfield Diagnostics AB can be used as a point of care device in overcrowded Emergency Departments (ED). Patients and Methods We used the strokefinder MD 100 by Medfield Diagnostics AB in two Greek National Health System (NHS) Hospitals Emergency Departments. Our research protocol was approved by local scientific and ethics committees. We prospectively enrolled 71 adult patients from two NHS emergency departments in whom stroke was included as a differential diagnosis after triage. The feasibility of using the Strokefinder MD 100 by Medfield Diagnostics AB in various emergency department settings was evaluated through a structured questionnaire. Results The strokefinder MD 100 was used on 71 patients in various settings in the Emergency Department. In every case, the test was completed at the patient bedside without interfering with other ongoing and diagnostic and resuscitation procedures. There was no additional delay to patient care caused by performing the test when compared with current local Emergency Department practice and protocol. In almost 90% of the cases, a clear result was produced by the device. Conclusion The Strokefinder MD 100 can be safely used as a point of care device by all trained healthcare professionals, in the most overcrowded emergency department, in various ED locations. MeSH terms Point of Care Systems, Cerebrovascular Stroke, Proof of Concept Study.

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“…Pathophysiological terms reflect this in the loss of 1.9 million neurons and 14 billion synapses approximately every minute after stroke onset [1,2]. In clinical terms, it is embodied in an increased risk of long-term disability, in-hospital mortality, and intraparenchymal haemorrhage for every 15-min delay in therapy administration [1,3,4]. Indeed, acute phase therapy is represented by revascularization therapies, such as thrombolysis and thrombectomy [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Unlocking the Potential of Stroke Blood Biomarkers: Early Diagnosis, Ischemic vs. Haemorrhagic Differentiation and Haemorrhagic Transformation Risk: A Comprehensive Review

Biase

Bonura

Pecoraro

et al. 2023

IJMS

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Stroke, a complex and heterogeneous disease, is a leading cause of morbidity and mortality worldwide. The timely therapeutic intervention significantly impacts patient outcomes, but early stroke diagnosis is challenging due to the lack of specific diagnostic biomarkers. This review critically examines the literature for potential biomarkers that may aid in early diagnosis, differentiation between ischemic and hemorrhagic stroke, and prediction of hemorrhagic transformation in ischemic stroke. After a thorough analysis, four promising biomarkers were identified: Antithrombin III (ATIII), fibrinogen, and ischemia-modified albumin (IMA) for diagnostic purposes; glial fibrillary acidic protein (GFAP), micro RNA 124-3p, and a panel of 11 metabolites for distinguishing between ischemic and hemorrhagic stroke; and matrix metalloproteinase-9 (MMP-9), s100b, and interleukin 33 for predicting hemorrhagic transformation. We propose a biomarker panel integrating these markers, each reflecting different pathophysiological stages of stroke, that could significantly improve stroke patients’ early detection and treatment. Despite promising results, further research and validation are needed to demonstrate the clinical utility of this proposed panel for routine stroke treatment.

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Neurophysiology tools to lower the stroke onset to treatment time during the golden hour: microwaves, bioelectrical impedance and near infrared spectroscopy

Cited by 4 publications

References 89 publications

Pre-hospital stroke monitoring past, present, and future: a perspective

Pre-hospital stroke monitoring past, present, and future: a perspective

Detecting Stroke at the Emergency Department by a Point of Care Device: A Multicenter Feasibility Study

Unlocking the Potential of Stroke Blood Biomarkers: Early Diagnosis, Ischemic vs. Haemorrhagic Differentiation and Haemorrhagic Transformation Risk: A Comprehensive Review

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