Neurophysiology of the pedunculopontine tegmental nucleus

Vitale, Flora; Capozzo, Annamaria; Mazzone, Paolo; Scarnati, Eugenio

doi:10.1016/j.nbd.2018.03.004

Cited by 33 publications

(28 citation statements)

References 203 publications

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“…DBS in the ventralis intermedius of the thalamus efficiently controls tremor while DBS in STN or Gpi have been used to treat bradykinesia but with little success in unlocking locomotor freezing 12 , 13 , 99 . More recently, stimulation targeting the PPN has been proposed as a tool to alleviate locomotor deficits in PD patients with the assumption that activating the PPN with DBS should release it from BG inhibition 26 , 27 , 76 . In support, akinesia is counteracted by PPN-DBS in PD primate models 100 .…”

Section: Discussionmentioning

confidence: 99%

Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism

Masini

Kiehn

2022

Nat Commun

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The pedunculopontine nucleus (PPN) is a locomotor command area containing glutamatergic neurons that control locomotor initiation and maintenance. These motor actions are deficient in Parkinson’s disease (PD), where dopaminergic neurodegeneration alters basal ganglia activity. Being downstream of the basal ganglia, the PPN may be a suitable target for ameliorating parkinsonian motor symptoms. Here, we use in vivo cell-type specific PPN activation to restore motor function in two mouse models of parkinsonism made by acute pharmacological blockage of dopamine transmission. With a combination of chemo- and opto-genetics, we show that excitation of caudal glutamatergic PPN neurons can normalize the otherwise severe locomotor deficit in PD, whereas targeting the local GABAergic population only leads to recovery of slow locomotion. The motor rescue driven by glutamatergic PPN activation is independent of activity in nearby locomotor promoting glutamatergic Cuneiform neurons. Our observations point to caudal glutamatergic PPN neurons as a potential target for neuromodulatory restoration of locomotor function in PD.

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Section: Discussionmentioning

confidence: 99%

Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism

Masini

Kiehn

2022

Nat Commun

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“…However, PPN/MRN neurons likely exert their role in movement initiation via additional brain regions. For example, PPN/ MRN Th neurons also project to the SNr and subthalamic nucleus (STN) (Figure 4A) (Martinez-Gonzalez et al, 2011;Vitale et al, 2019;Ferreira-Pinto et al, 2021). STN in turn projects to SNr, and SNr is known to control premotor circuits in the SC and medulla (DeLong, 1990;Hikosaka et al, 2000;Klaus et al, 2019).…”

Section: Limitation Of the Studymentioning

confidence: 99%

A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

Inagaki

Chen

Ridder

et al. 2022

Cell

111

102

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“…Although we emphasize the PPN/MRNTh ® thalALM ® ALM circuit here, PPN/MRN neurons likely exert their role in movement initiation via additional brain regions. For example, PPN/MRNTh neurons also project to the SNr and subthalamic nucleus (STN) ( Figure 4A) (Martinez-Gonzalez et al, 2011;Vitale et al, 2019). STN in turn projects to SNr, and SNr is known to control premotor circuits in the superior colliculus and medulla (DeLong, 1990;Hikosaka et al, 2000;Klaus et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

A midbrain - thalamus - cortex circuit reorganizes cortical dynamics to initiate planned movement

Inagaki

Chen

et al. 2020

Preprint

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Motor behaviors are often planned long before execution, but only released after specific sensory events. Planning and execution are each associated with distinct patterns of motor cortex activity. Key questions are how these dynamic activity patterns are generated and how they relate to behavior. Here we investigate the multi-regional neural circuits that link an auditory ‘go cue’ and the transition from planning to execution of directional licking. Ascending glutamatergic neurons in the midbrain reticular and pedunculopontine nuclei show short-latency and phasic changes in spike rate that are selective for the go cue. This signal is transmitted via the thalamus to the motor cortex, where it triggers a rapid reorganization of motor cortex state from planning-related activity to a motor command, which in turn drives appropriate movement. Our studies show how brainstem structures can control cortical dynamics via the thalamus for rapid and precise motor behavior.

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Neurophysiology of the pedunculopontine tegmental nucleus

Cited by 33 publications

References 203 publications

Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism

Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism

A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

A midbrain - thalamus - cortex circuit reorganizes cortical dynamics to initiate planned movement

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