Neurophysiological Double-Blind Trial of a Botulinum Neurotoxin Type A Free of Complexing Proteins

Wohlfarth, Kai; Müller, Christian; Sassin, Irena; Comes, Georg; Grafe, Susanne

doi:10.1097/01.wnf.0000240951.18821.50

Cited by 71 publications

(64 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This prolonged atrophy has been reported previously using electromyographic examinations 16 and from patients surviving botulism. 50 It should be considered when repeated BoNT/A injections are performed into the same muscles because of the vanishing clinical effect after 3-6 (-12) months according to the standard schedule.…”

Section: Discussionmentioning

confidence: 66%

“…For the preparation XEOMIN 1 published data support a clinical ''one to one'' dose relation of XEOMIN 1 for different dose amounts compared to the preparation of BOTOX 1 (Allergan), 16,48 an assumption which has been doubted recently. 49 However, because all licensed BoNT/A preparations show the same mechanism of action (cleavage of SNAP 25 protein), the described phenomenon within the muscle is not likely to be specific for any BoNT/A preparation.…”

Section: Discussionmentioning

confidence: 88%

“…[1][2][3]15 Long-term effects of BoNT/A injected into affected muscle have been studied using e.g. compound muscle action potential M-wave amplitudes with EMG, 16 computed tomography (CT), 7,9 and occasionally magnetic resonance imaging (MRI). 8,17 The fine structural effects on injected muscles have been investigated in animal experiments including rats, [18][19][20][21][22][23][24][25] mice, [26][27][28] chicken, 4 rabbits, 29,30 cats, 31 and monkeys.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Muscle biopsy substantiates long‐term MRI alterations one year after a single dose of botulinum toxin injected into the lateral gastrocnemius muscle of healthy volunteers

Schroeder

Ertl‐Wagner²,

Britsch³

et al. 2009

Movement Disorders

106

View full text Add to dashboard Cite

Despite numerous clinical and experimental studies on botulinum toxin type A (BoNT/A), long-term alterations of muscle texture and fine structure following BoNT/A treatment have thus far not been studied in normal human skeletal muscle. After obtaining institutional review board approval, we performed a prospective, placebo-controlled, double-blinded follow-up study on two healthy adults using magnetic resonance imaging (MRI) and muscle biopsy to visualize long-term alterations after a single BoNT/A injection into the lateral head of the gastrocnemius muscle. MRI disclosed a high-signal-intensity pattern in short tau inversion recovery sequences, and a reduction of the cross-sectional area in the BoNT/A-injected, but not in the saline-injected contralateral control muscle (at 6 to 9 months in volunteer A: 73%, in B: 62%; at 12 months in A: 88%, and in B: 78%). Enzyme histochemistry, 12 months after injection, confirmed neurogenic atrophy of muscle fibers only in the BoNT/A-injected muscle. Electron microscopy revealed additional degenerative changes at the neuromuscular junction. The data confirm that MRI is a suitable tool to monitor the long-term effect of BoNT/A on skeletal muscle. Neurogenic muscle atrophy following a single BoNT/A injection should be taken into consideration when repeated BoNT/A injections into the same muscles are proposed.

show abstract

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 88%

mentioning

confidence: 99%

See 1 more Smart Citation

Muscle biopsy substantiates long‐term MRI alterations one year after a single dose of botulinum toxin injected into the lateral gastrocnemius muscle of healthy volunteers

Schroeder

Ertl‐Wagner²,

Britsch³

et al. 2009

Movement Disorders

106

View full text Add to dashboard Cite

show abstract

“…Ayrıca 1U Botox, 1U Dysport"a göre 3 kat daha toksiktir 22 . Xeomin dondurularak kurutulmuĢ saflaĢtırılmıĢ ve yardımcı kompleks proteinler (hemaglutinin ve nonhemaglutinin) içermeyen btx-a"dır 2,23,24 . Diğer btx-a ürünlerinden daha az immünojeniktir 2 .…”

Section: Hazırlanıģı Ve ġçErikleriunclassified

Di̇ş Heki̇mli̇ği̇nde Botoks: Derleme

Soğancı¹,

Yağci²

2016

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

View full text Add to dashboard Cite

“…Comparative studies performed to evaluate efficacy and safety indicated that 1 Botox unit equals 1 unit of Xeomin, 3–5 Dysport and 50–100 Myoblock/Neuroblock units [2, 13, 56, 66, 67]. Results concerning the therapeutic effects of Xeomin are promising; however, those analyzing its biological potency are contrasting [68,69,70]; therefore, further research is required. The lower amount of the included neurotoxin A and the lack of complexing proteins from this product result in its lower antigenicity [71].…”

Section: Pharmaceutical Preparations Of Botulinum Neurotoxinsmentioning

confidence: 99%

Botulinum Neurotoxin: The Ugly Duckling

Koussoulakos¹

2009

Eur Neurol

View full text Add to dashboard Cite

This review presents a brief account of the most significant biological effects and clinical applications of botulinum neurotoxins, in a way comprehensive even for casual readers who are not familiar with the subject. The most toxic known substances in botulinum neurotoxins are polypeptides naturally synthesized by bacteria of the genus Clostridium. These polypeptides inhibit acetylcholine release at neuromuscular junctions, thus causing muscle paralysis involving both somatic and autonomic innervation. There is substantial evidence that this muscle-paralyzing feature of botulinum neurotoxins is useful for their beneficial influence on more than 50 pathological conditions such as spastic paralysis, cerebral palsy, focal dystonia, essential tremor, headache, incontinence and a variety of cosmetic interventions. Injection of adequate quantities of botulinum toxins in spastic muscles is considered as a highly hopeful procedure for the treatment of people who suffer from dystonia, cerebral palsy or have experienced a stroke. So far, numerous and reliable studies have established the safety and efficacy of botulinum neurotoxins and advocate wider clinical therapeutic and cosmetic applications.

show abstract

Neurophysiological Double-Blind Trial of a Botulinum Neurotoxin Type A Free of Complexing Proteins

Abstract: NT 201 is effective and safe in inducing the desired paretic effect.

Cited by 71 publications

References 16 publications

Muscle biopsy substantiates long‐term MRI alterations one year after a single dose of botulinum toxin injected into the lateral gastrocnemius muscle of healthy volunteers

Muscle biopsy substantiates long‐term MRI alterations one year after a single dose of botulinum toxin injected into the lateral gastrocnemius muscle of healthy volunteers

Di̇ş Heki̇mli̇ği̇nde Botoks: Derleme

Botulinum Neurotoxin: The Ugly Duckling

Contact Info

Product

Resources

About