Neurophysiological correlates of metabolic syndrome and cognitive impairment in schizophrenia: A structural equation modeling approach

Boyer, Laurent; Testart, J.; Michel, Pierre; Richieri, Raphaëlle; Faget-Agius, Catherine; Vanoye, Violette; Auquier, Pascal; Lançon, Christophe; Guedj, Éric

doi:10.1016/j.psyneuen.2014.07.019

Cited by 24 publications

(22 citation statements)

References 56 publications

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“…Change in blood markers is also one of the most important manifestations of chronic cerebral ischemic diseases. 18,19 In our study, the research of all indices in blood indicated that CRP, S100B, MBP, HSP-70 and NSE in the blood of patients in the CCCI group had a significant increase compared with the depression group. CRP level is one of the commonest markers for body inflammatory reactions during the clinical application.…”

Section: Discussionsupporting

confidence: 47%

Analyzing the neuropsychological characteristics and changes in serum markers of patients with chronic cerebral circulation insufficiency

Tang

Zhen

et al. 2018

Rev. Assoc. Med. Bras.

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Section: Discussionsupporting

confidence: 47%

Analyzing the neuropsychological characteristics and changes in serum markers of patients with chronic cerebral circulation insufficiency

Tang

Zhen

et al. 2018

Rev. Assoc. Med. Bras.

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“…A high rate of somatic comorbidities (84 %) has been found in the present sample (Table 1). Metabolic syndrome and cardiovascular comorbidities have been recently associated with cognitive impairment and poor outcomes (Lancon et al 2012;Boyer et al 2014;Micoulaud-Franchi et al 2015;Godin et al 2015). A recent study highlighted the lack of appropriate treatment for somatic comorbidities in patients with schizophrenia (Godin et al 2015).…”

Section: Resultsmentioning

confidence: 99%

Potentially inappropriate psychotropic prescription at discharge is associated with lower functioning in the elderly psychiatric inpatients. A cross-sectional study

et al. 2016

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In the current increasingly fragmented health care systems, special attention must be given to PIP prescription in older population suffering from psychiatric disorders. Using the Beers criteria, the present study demonstrates the high prevalence of PIP prescription, which concerns a large panel of drugs but mostly anxiolytics and hypnotics independently of psychiatric or somatic diagnoses and sociodemographic characteristics. Our study has demonstrated for the first time an association between PIP prescription and lowered patient functioning. Further longitudinal studies should confirm a potential causal relation.

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“…However, based on the findings described above, cerebral hypoperfusion may also be linked to impaired vasodilation that is mechanistically linked to reduced neurovascular eNOS-dependent NO biosynthesis (16, 51) (Figure 1). Pro-inflammatory state associated with metabolic syndrome can also impair endothelial eNOS function (24, 63). Moreover, sustained cerebral hypoperfusion can further compromise endothelial mitochondrial oxidative function, increasing the formation of endothelial ROS (64, 65), which in turn promotes eNOS uncoupling and lowers endothelial NO levels, thereby further reducing cerebral perfusion in a positive feedback loop (53–56).…”

Section: Theoretical Integration Of Oxidative and Neuroinflammatory Mmentioning

confidence: 99%

“…A 99mTc-ECD-single-photon emission computed tomography brain imaging study found that schizophrenia patients with metabolic syndrome had more significant cerebral hypoperfusion associated with substantially lower frontal executive functions, compared with those without metabolic syndrome (63). This suggested a mechanistic link between neurovascular endothelial dysfunction and cognitive deficits in schizophrenia.…”

Section: Theoretical Integration Of Oxidative and Neuroinflammatory Mmentioning

confidence: 99%

Neurovascular Unit Dysfunction and Blood–Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experimental Evidence

et al. 2017

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Schizophrenia is a psychotic disorder characterized by delusions, hallucinations, negative symptoms, as well as behavioral and cognitive dysfunction. It is a pathoetiologically heterogeneous disorder involving complex interrelated mechanisms that include oxidative stress and neuroinflammation. Neurovascular endothelial dysfunction and blood–brain barrier (BBB) hyperpermeability are established mechanisms in neurological disorders with comorbid psychiatric symptoms such as epilepsy, traumatic brain injury, and Alzheimer’s disease. Schizophrenia is frequently comorbid with medical conditions associated with peripheral vascular endothelial dysfunction, such as metabolic syndrome, cardiovascular disease, and diabetes mellitus. However, the existence and etiological relevance of neurovascular endothelial dysfunction and BBB hyperpermeability in schizophrenia are still not well recognized. Here, we review the growing clinical and experimental evidence, indicating that neurovascular endotheliopathy and BBB hyperpermeability occur in schizophrenia patients. We present a theoretical integration of human and animal data linking oxidative stress and neuroinflammation to neurovascular endotheliopathy and BBB breakdown in schizophrenia. These abnormalities may contribute to the cognitive and behavioral symptoms of schizophrenia via several mechanisms involving reduced cerebral perfusion and impaired homeostatic processes of cerebral microenvironment. Furthermore, BBB disruption can facilitate interactions between brain innate and peripheral adaptive immunity, thereby perpetuating harmful neuroimmune signals and toxic neuroinflammatory responses, which can also contribute to the symptoms of schizophrenia. Taken together, these findings support the “mild encephalitis” hypothesis of schizophrenia. If neurovascular abnormalities prove to be etiologically relevant to the neurobiology of schizophrenia, then targeting these abnormalities may represent a promising therapeutic strategy.

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Neurophysiological correlates of metabolic syndrome and cognitive impairment in schizophrenia: A structural equation modeling approach

Cited by 24 publications

References 56 publications

Analyzing the neuropsychological characteristics and changes in serum markers of patients with chronic cerebral circulation insufficiency

Analyzing the neuropsychological characteristics and changes in serum markers of patients with chronic cerebral circulation insufficiency

Potentially inappropriate psychotropic prescription at discharge is associated with lower functioning in the elderly psychiatric inpatients. A cross-sectional study

Neurovascular Unit Dysfunction and Blood–Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experimental Evidence

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