1995
DOI: 10.1677/joe.0.1440225
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Neurophysin stimulates prolactin release from primary cultured rat pituitary cells

Abstract: The neurohypophysial hormones, oxytocin and vasopressin, are present as non-covalently bound complexes with their designated neurophysin in the secretory granules of the posterior pituitary. The neurophysins are generally considered to be biologically inert carrier proteins for oxytocin and vasopressin. We have examined the actions of bovine neurophysin-I (bNP-I), bovine neurophysin-II (bNP-II), rat neurophysin (rat NP) and oxytocin on prolactin release using primary cultured rat pituitary cells. A dynamic per… Show more

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Cited by 7 publications
(4 citation statements)
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“…Indeed this is also the case for other invertebrate neuropeptide precursor-related peptides such as adipokinetic hormone precursor-related peptides (APRPs) (Fischer-Lougheed et al 1993;Hekimi and O'Shea 1989), and for vertebrate examples such as the neurophysins (Ando et al 1988; Is crustacean hyperglycaemic hormone precursor-related peptide a circulating neurohormone in crabs? Shin et al 1995) and insulin intrachain connecting peptide (Wahren et al 1996). Accordingly, a first step towards identification of possible functions for CPRP would be to describe neuroanatomical architecture, in comparison with cHH, and release patterns of both peptides, in vitro and in vivo, to determine: (a) whether both peptides are co-released, (b) that CPRP circulates in the haemolymph, and (c) the clearance dynamics of CPRP in relation to cHH.…”
Section: Introductionmentioning
confidence: 99%
“…Indeed this is also the case for other invertebrate neuropeptide precursor-related peptides such as adipokinetic hormone precursor-related peptides (APRPs) (Fischer-Lougheed et al 1993;Hekimi and O'Shea 1989), and for vertebrate examples such as the neurophysins (Ando et al 1988; Is crustacean hyperglycaemic hormone precursor-related peptide a circulating neurohormone in crabs? Shin et al 1995) and insulin intrachain connecting peptide (Wahren et al 1996). Accordingly, a first step towards identification of possible functions for CPRP would be to describe neuroanatomical architecture, in comparison with cHH, and release patterns of both peptides, in vitro and in vivo, to determine: (a) whether both peptides are co-released, (b) that CPRP circulates in the haemolymph, and (c) the clearance dynamics of CPRP in relation to cHH.…”
Section: Introductionmentioning
confidence: 99%
“…Neurophysin 1 is the carrier protein of oxytocin, and neurophysin 2 is the carrier protein of vasopressin. Because the two neurohypophysial hormones are packaged together with neurophysin in secretory granules, a neurophysin is also released when a neurohypophysial hormone is released [ 39 ]. In avian species, vasopressin and oxytocin are replaced by arginine vasotocin (AVT) and mesotocin (MT), respectively, and they have also two types of neurophysins associated with the corresponding precursors [ 40 , 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, oxytocin and vasopressin might contribute little, if anything, to the direct PRF activity of the PP extract. Neurophysin, a carrier protein for oxytocin and vasopressin, is also abundant in the PP, and this peptide is reported to stimulate PRL release from cultured rat pituitary cells (Shin et al. 1995).…”
Section: Discussionmentioning
confidence: 99%