Neuropharmacology of Organoselenium Compounds in Mental Disorders and Degenerative Diseases

Abstract

Neurodegenerative and mental disorders are a public health burden with pharmacological treatments of limited efficacy. Organoselenium compounds are receiving great attention in medicinal chemistry mainly because of their antioxidant and immunomodulatory activities, with a multi-target profile that can favor the treatment of multifactorial diseases. Therefore, the purpose of this review is to discuss recent preclinical studies about organoselenium compounds as therapeutic agents for the management of mental (e.g., depression, anxiety, bipolar disorder, and schizophrenia) and neurodegenerative diseases (e.g., Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and multiple sclerosis). We have summarized around 70 peer-reviewed articles from 2016 to the present that used in silico, in vitro, and/or in vivo approaches to assess the neuropharmacology of selenium-containing compounds. Among the diversity of organoselenium molecules investigated in the last five years, diaryl diselenides, Ebselen-derivatives, and Se-containing heterocycles are the most representative. Ultimately, this review is expected to provide disease-oriented information regarding the neuropharmacology of organoselenium compounds that can be useful for the design, synthesis, and pharmacological characterization of novel bioactive molecules that can potentially be clinically viable candidates.

Biosynthesis of selenium nanoparticles by Candida albicans and them antimicrobial effects

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Selenium-Containing Agents Acting on Cancer—A New Hope?

“…Moreover, selenomethionine 1 has been considered as a potential candidate for the treatment of coronavirus infections owing to its antioxidant and immunomodulatory properties [ 43 , 44 ]. Lastly, ebselen 4 and its derivatives exhibited neuroprotective effects against different toxicants, thus suggesting a possible future interest in managing mental disorders and degenerative diseases [ 45 , 46 , 47 ].…”

Synthesis, Reactions, and Antioxidant Properties of Bis(3-amino-1-hydroxybenzyl)diselenide

“…Due to the biological significance of antioxidants, there have been various attempts to replicate their action using specific types of small molecules, such as selenium (Se) compounds. − Ebselen ( 1 ) is the most extensively studied cyclic selenenamide found to be a good GPx mimic and anti-inflammatory agent (Figure ). , …”