Neuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: Sedative effect and chemical analysis of an aqueous extract

Martínez‐Vázquez, Mariano; Estrada-Reyes, Rosa; Martínez-Laurrabaquio, A.; López‐Rubalcava, Carolina; Heinze, Gerardo

doi:10.1016/j.jep.2012.03.028

Cited by 65 publications

(35 citation statements)

References 41 publications

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“…The FST method used to assess antidepressant activity was similar to that described by Herrera-Ruiz and Martínez-Vázquez [8][9]. The apparatus consisted of a glass vessel (25 cm height × 12 cm diameter) filled with water to a depth of 15 cm (24 ± 1°C).…”

Section: Forced Swimming Test (Fst)mentioning

confidence: 99%

Linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway

et al. 2015

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Section: Forced Swimming Test (Fst)mentioning

confidence: 99%

Linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway

et al. 2015

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“…In this test, the HcMeOH was administered at doses of 310, 100 and 31 mg/kg (experimental treatment, n = 10), DZP at 1 mg/kg (positive control, n = 10) and ss 0.1% (control group, n = 10), 60 min before the beginning of the test [12]. The open field test was used to evaluate the locomotor activity of mice that had previously been subjected to the FST and EPM tests.…”

Section: Methodsmentioning

confidence: 99%

Heteropterys cotinifolia: A Neuropharmacological and Phytochemical Approach with Possible Taxonomic Implications

Huerta-Reyes

Zamilpa

Álvarez-Chimal

et al. 2013

The Scientific World Journal

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Heteropterys cotinifolia (Malpighiaceae) has been used in traditional Mexican medicine mainly for the treatment of nervous disorders. However, the specific neuropharmacological activities responsible for this use remain to be defined. The present study evaluates the antidepressant and anxiolytic effects produced by the methanolic extract of Heteropterys cotinifolia and the influence of such effects on motor activity in ICR mice. Our results show that the methanolic extract of Heteropterys cotinifolia produces a dose-dependent antidepressant effect in the forced swimming test in mice at doses from 31 to 310 mg/kg, with no reduction of mice locomotion. However, no anxiolytic properties were observed. Our findings suggest that the main extract compounds identified as chlorogenic acid and rutin may be involved in the antidepressant effects. To our knowledge, the present study constitutes the first report of pharmacological and phytochemical data of Heteropterys cotinifolia. The presence of flavonoids in the methanolic extract of Heteropterys cotinifolia may also provide further data to characterize taxonomically this species in order to be distinguished from others species closely related and belonging to the same genus.

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“…The Rota Rod Test measures the muscle relaxation effect or motor incoordination produced, for example, by anxiolytics and/or sedatives (Torres and Escarabajal, 2002;Martínez-Vázquez et al, 2012). This test was conducted through two sessions (habituation in apparatus and test).…”

Section: Motor Coordinationmentioning

confidence: 99%

Effects of bark flour of Passiflora edulis on food intake, body weight and behavioral response of rats

Figueiredo

Pordeus

Paulo

et al. 2016

Revista Brasileira de Farmacognosia

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a b s t r a c tEffects of treatment with the bark flour of Passiflora edulis Sims, Passifloraceae, were evaluated. Adult male Wistar rats were treated for 30 days (130 mg/kg, p.o.) with the albedo flour, flavedo and full bark of P. edulis, corresponding to albedo associated with flavedo. Behavioral response observed after treatment with bark flour P. edulis showed sedative effects by the reduction of exploratory activity and increased duration of immobility in the open field test for the group of animals that received the albedo flour associated with the flavedo. Sedative effects were observed in the absence of motor incoordination or muscle relaxation. Food intake of experimental animals was not changed, but the weight gain was decreased both in animals that received only albedo flour, and in those who received the full bark flour. The full bark flour of Passiflora showed sedative effects, without anxiolytic effect detectable and muscle relaxation or motor incoordination, and reduces body weight gain.

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Neuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: Sedative effect and chemical analysis of an aqueous extract

Cited by 65 publications

References 41 publications

Linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway

Linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway

Heteropterys cotinifolia: A Neuropharmacological and Phytochemical Approach with Possible Taxonomic Implications

Effects of bark flour of Passiflora edulis on food intake, body weight and behavioral response of rats

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