Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease

Biradar, Siddaruda M; Joshi, Hanumanthachar; Chheda, Tarak K.

doi:10.1016/j.ejphar.2012.02.042

Cited by 52 publications

(31 citation statements)

References 39 publications

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“…Increased tau phosphorylation was detected in db/db mice as previously described (40). We observed that MGF treatment significantly reduced cortical phospho-tau/total tau ratio [F (3,20) Figure 4B).…”

Section: Mgf Treatment Reduces Tau Hyperphosphorylation In Db/db Micesupporting

confidence: 83%

“…MGF improves cognition in normal rats (36) as well as in different models with learning and memory disabilities (3,19,27). However, to our knowledge spatial and episodic memory have not been assessed in db/db mice treated with MGF.…”

Section: Discussionmentioning

confidence: 88%

“…Individual weekly assessment revealed that before commencement of the treatment, body weight was significantly increased in db/db and db/ db-MGF treated mice [F (3,37) Figure 1B). Individual weekly assessment revealed that before commencement of the treatment, body weight was significantly increased in db/db and db/ db-MGF treated mice [F (3,37) Figure 1B).…”

Section: Improvement Of Metabolic Parameters After Long-term Mgf Treamentioning

confidence: 99%

“…We detected a significant group 3 week effect when body weight was compared among groups [F(9,121) 5 3.59, **P < 0.01]. Individual weekly assessment revealed that before commencement of the treatment, body weight was significantly increased in db/db and db/ db-MGF treated mice [F (3,37) Figure 1B). Insulin levels were progressively reduced in db/db mice, as pancreas became exhausted, however db/db-MGF treated mice maintained high insulin levels longer when compared with db/db mice.…”

Section: Improvement Of Metabolic Parameters After Long-term Mgf Treamentioning

confidence: 99%

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Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model

et al. 2016

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Epidemiological studies reveal that metabolic disorders, and specifically type 2 diabetes (T2D), are relevant risk factors to develop Alzheimer's disease (AD) and vascular dementia (VaD), the most common causes of dementia. AD patients are in a tremendous need of new therapeutic options because of the limited success of available treatments. Natural polyphenols, and concretely Mangifera indica Linn extract (MGF), have been reported to have antiinflammatory, antioxidant and antidiabetic activities. The role of MGF in central complications associated with T2D, after long-term treatment of db/db mice with MGF was analyzed. Metabolic parameters (body weight, glucose and insulin levels) as well as central complications including brain atrophy, inflammatory processes, spontaneous bleeding, tau phosphorylation and cognitive function in db/db mice treated with MGF for 22 weeks were assessed. MGF limits body weight gain in obese db/db mice. Insulin and C-peptide levels, indicative of pancreatic function, were longer maintained in MGF-treated animals. MGF reduced central inflammation by lowering microglia burden, both in the cortex and the hippocampus. Likewise, central spontaneous bleeding was significantly reduced in db/db mice. Cortical and hippocampal atrophy was reduced in db/db mice and tau hyperphosphorylation was lower after MGF treatment, resulting in partial recovery of learning and memory disabilities. Altogether, the data suggested that MGF treatment may provide a useful tool to target different aspects of AD and VaD pathology, and could lead to more effective clinical therapies for the prevention of metabolic related central complications associated with AD and VaD.

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Section: Mgf Treatment Reduces Tau Hyperphosphorylation In Db/db Micesupporting

confidence: 83%

Section: Discussionmentioning

confidence: 88%

Section: Improvement Of Metabolic Parameters After Long-term Mgf Treamentioning

confidence: 99%

Section: Improvement Of Metabolic Parameters After Long-term Mgf Treamentioning

confidence: 99%

See 2 more Smart Citations

Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model

et al. 2016

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“…A number of biological activities of mangiferin have been suggested, including antioxidant, antiviral, antitumor, anti-allergic, antidiabetic, hepato-and cardioprotective, anti-inflammatory and immunomodulatory effects (Sato et al, 1992;Guha et al, 1996;Garcia et al, 2003;Pardo-Andreu et al, 2006;Das et al, 2012;Vyas et al, 2012). Furthermore, mangiferin (10-40 mg/kg) has been shown to significantly improve the scopolamine-associated loss of learning ability in Elevated plus Maze, Water Maze, and Passive Shock Avoidance behavioral models through inhibitions of whole brain acetyl cholinesterase and lipid peroxidation, and by restoration of reduced glutathione (Jung et al, 2009;Biradar et al, 2012). We previously showed that mangiferin affords gastroprotection against ethanol or indomethacin-induced gastric damage (Carvalho et al, 2007), exerts prokinetic action on gastrointestinal transit (Cavalcante Morais et al, 2012), and neuroprotection in ketamine-induced schizophrenia model (Rao et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Peripheral antinociceptive action of mangiferin in mouse models of experimental pain: Role of endogenous opioids, KATP-channels and adenosine

Lopes

Silva

Arruda

et al. 2013

Pharmacology Biochemistry and Behavior

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This study aimed to assess the possible systemic antinociceptive activity of mangiferin and to clarify the underlying mechanism, using the acute models of chemical (acetic acid, formalin, and capsaicin) and thermal (hot-plate and tail-flick) nociception in mice. Mangiferin at oral doses of 10 to 100 mg/kg evidenced significant antinociception against chemogenic pain in the test models of acetic acid-induced visceral pain and in formalin- and capsaicin-induced neuro-inflammatory pain, in a naloxone-sensitive manner, suggesting the participation of endogenous opiates in its mechanism. In capsaicin test, the antinociceptive effect of mangiferin (30 mg/kg) was not modified by respective competitive and non-competitive transient receptor potential vanilloid 1 (TRPV1) antagonists, capsazepine and ruthenium red, or by pretreatment with L-NAME, a non-selective nitric oxide synthase inhibitor, or by ODQ, an inhibitor of soluble guanylyl cyclase. However, mangiferin effect was significantly reversed by glibenclamide, a blocker of K(ATP) channels and in animals pretreated with 8-phenyltheophylline, an adenosine receptor antagonist. Mangiferin failed to modify the thermal nociception in hot-plate and tail-flick test models, suggesting that its analgesic effect is only peripheral but not central. The orally administered mangiferin (10-100 mg/kg) was well tolerated and did not impair the ambulation or the motor coordination of mice in respective open-field and rota-rod tests, indicating that the observed antinociception was unrelated to sedation or motor abnormality. The findings of this study suggest that mangiferin has a peripheral antinociceptive action through mechanisms that involve endogenous opioids, K(ATP)-channels and adenosine receptors.

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Progress in the development of naturally derived active metabolites‐based drugs: Potential therapeutics for Alzheimer's disease

Mani

Sulthana

Muthusamy

et al. 2022

Biotech and App Biochem

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Alzheimer's disease (AD) is an extensive age-associated neurodegenerative disorder. In spite of wide-ranging progress in understanding the AD pathology for the past 50 years, clinical trials based on the hypothesis of amyloid-beta (Aβ) have reserved worsening particularly at late-stage human trials. Consequently, very few old drugs are presently used for AD with inadequate clinical consequences and various side effects. We focus on widespread pharmacological and beneficial principles for existing as well as future drugs. Multitargeting approaches by means of general antioxidant and anti-inflammatory mechanisms allied with particular receptor and/or enzyme-mediated actions in neuroprotection and neurodegeneration. The plant kingdom comprises a vast range of species with an incredible diversity of bioactive metabolites with diverse chemical scaffolds. In recent times, an increasing body of facts recommended the use of phytochemicals to decelerate AD's onset and progression. The definitive goal of AD investigation is to avert the onset of neurodegeneration, thereby allowing successful aging devoid of cognitive decline. At this point, we discussed the neurological protective role of natural products and naturally derived therapeutic agents for AD from various natural polyphenolic compounds and medicinal plants. In conclusion, medicinal plants act as a chief source of different bioactive constituents.

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Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease

Cited by 52 publications

References 39 publications

Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model

Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model

Peripheral antinociceptive action of mangiferin in mouse models of experimental pain: Role of endogenous opioids, KATP-channels and adenosine

Progress in the development of naturally derived active metabolites‐based drugs: Potential therapeutics for Alzheimer's disease

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