Progress in the development of naturally derived active metabolites‐based drugs: Potential therapeutics for Alzheimer's disease

Abstract

Alzheimer's disease (AD) is an extensive age-associated neurodegenerative disorder. In spite of wide-ranging progress in understanding the AD pathology for the past 50 years, clinical trials based on the hypothesis of amyloid-beta (Aβ) have reserved worsening particularly at late-stage human trials. Consequently, very few old drugs are presently used for AD with inadequate clinical consequences and various side effects. We focus on widespread pharmacological and beneficial principles for existing as well as future drugs. Multitargeting approaches by means of general antioxidant and anti-inflammatory mechanisms allied with particular receptor and/or enzyme-mediated actions in neuroprotection and neurodegeneration. The plant kingdom comprises a vast range of species with an incredible diversity of bioactive metabolites with diverse chemical scaffolds. In recent times, an increasing body of facts recommended the use of phytochemicals to decelerate AD's onset and progression. The definitive goal of AD investigation is to avert the onset of neurodegeneration, thereby allowing successful aging devoid of cognitive decline. At this point, we discussed the neurological protective role of natural products and naturally derived therapeutic agents for AD from various natural polyphenolic compounds and medicinal plants. In conclusion, medicinal plants act as a chief source of different bioactive constituents.

In Silico Identification of a Potential TNF-Alpha Binder Using a Structural Similarity: A Potential Drug Repurposing Approach to the Management of Alzheimer’s Disease

“…Emerging evidence suggests that the plant Rauwolfia vomitoria (RV) possesses compounds capable of preventing neuronal damage and reducing inflammation in the brain with minimal side effects [17][18][19][20]. This plant has exhibited promising therapeutic effects on cognitive deficit, among other plants that may have a beneficial effect on cognitive function [20][21][22]. Rauwolfia vomitoria is an ethnomedicinal plant commonly used in traditional African medicine for various ailments, including inflammation [23][24][25].…”