Neuropeptides of the autonomic nervous system in Sjogren's syndrome

Santavirta, Nina; Konttinen, Yrjö T.; Törnwall, Jyrki; Segerberg, Margaretha; Santavirta, Seppo; Matucci‐Cerinic, Marco; Björvell, Hjördis

doi:10.1136/ard.56.12.737

Cited by 39 publications

(30 citation statements)

References 22 publications

(11 reference statements)

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“…However, salivary amylase has been considered to be an indicator of sympathetic activation. NPY is co released with norepinephrine and salivary NPY has been detected according to the published literature (Dawidson et al, 1997;Naito et al, 2003;Santavirta et al, 1997). It should be noted that the salivary levels of NPY reported in the literature are very low.…”

Section: Stress Profile Approachmentioning

confidence: 93%

“…Acetylcholine is the traditional indicator of parasympathetic activation however it is not detectable in saliva. VIP is co-released with acetylcholine from parasympathetic nerves which makes it a good indicator of parasympathetic activity or tone (Dawidson et al, 1997;Naito et al, 2003;Santavirta et al, 1997). In addition a statistically significant correlation between salivary NPY and VIP may indicate how well a subject responds to stress since these two hormones have opposite effects with respect to vagal tone.…”

Section: Stress Profile Approachmentioning

confidence: 99%

“…One of the goals of this study is to determine if NPY can differentiate between physical and psychological stress. In order to accomplish this we will try to assay NPY in saliva which is much less invasive than taking blood (Dawidson et al, 1997;Naito et al 2003;Santavirta et al, 1997).…”

Section: Salivary Neuropeptide Y As a Marker For Stressmentioning

confidence: 99%

“…VIP is also detectable in saliva (Dawidson et al, 1997;Naito et al, 2003;Santavirta et al, 1997). In one study comparing patients with Sjogren's syndrome and normal healthy subjects, stress as assessed by a Jenkins Activity Survey was associated with higher salivary VIP concentrations (Santavirta et al, 1997).…”

Section: Salivary Vasoactive Intestinal Peptide As a Marker For Stressmentioning

confidence: 99%

“…In one study comparing patients with Sjogren's syndrome and normal healthy subjects, stress as assessed by a Jenkins Activity Survey was associated with higher salivary VIP concentrations (Santavirta et al, 1997). Another noteworthy study found elevated salivary VIP and salivary CGRP in rhinosinusitis and migraine patients (Bellamy et al, 2006).…”

Section: Salivary Vasoactive Intestinal Peptide As a Marker For Stressmentioning

confidence: 99%

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Salivary VIP concentrations are elevated in humans after acute stress

et al. 2013

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Section: Stress Profile Approachmentioning

confidence: 93%

Section: Stress Profile Approachmentioning

confidence: 99%

Section: Salivary Neuropeptide Y As a Marker For Stressmentioning

confidence: 99%

Section: Salivary Vasoactive Intestinal Peptide As a Marker For Stressmentioning

confidence: 99%

Section: Salivary Vasoactive Intestinal Peptide As a Marker For Stressmentioning

confidence: 99%

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Salivary VIP concentrations are elevated in humans after acute stress

et al. 2013

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Alterations of Tear Neuromediators in Dry Eye Disease

et al. 2011

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To evaluate tear levels of neuromediators in patients with dry eye disease and to identify statistical correlations with the clinical findings.Methods: Nineteen patients with dry eye disease (Sjö gren syndrome, n=5 patients; non-Sjö gren syndrome, n=10; and ocular cicatricial pemphigoid, n = 4) and 12 healthy volunteers were enrolled. The eyes of all participants were evaluated by slitlamp examination, Schirmer testing, fluorescein staining, and tear film break-up time. Grading of dry eye severity was recorded. Tear samples were collected, and substance P, calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), vasoactive intestinal peptide, and nerve growth factor (NGF) concentrations were evaluated by enzyme-linked immunoassay and correlated with the clinical findings.Results: Nerve growth factor tear levels were significantly increased in participants with dry eye disease; CGRP and NPY concentrations were significantly decreased when compared with those in healthy participants. Dry eye severity showed a direct correlation with NGF and an inverse correlation with CGRP and NPY tear levels. Nerve growth factor tear levels showed a direct correlation with conjunctival hyperemia and fluorescein staining results, CGRP directly correlated with Schirmer test values, and NPY inversely correlated with tear film break-up time. Subgroup analysis showed that CGRP and NPY but not NGF were changed in autoimmune (ie, Sjö gren syndrome and ocular cicatricial pemphigoid) dry eye disease. Conclusions:The decreased tear levels of NPY and CGRP in dry eye disease are related to impaired lacrimal function, and tear levels of NGF are more closely related to corneal epithelial damage. Our findings suggest that NPY, CGRP, and NGF could become useful markers of dry eye severity.

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Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjögren's syndrome patients: Correlation with reduced structural integrity of acini and ducts

Goicovich

Molina

Pérez

et al. 2003

Arthritis & Rheumatism

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Our observation that the proteolytic action of MMPs toward ECM macromolecules is increased in SS patients provides a rationale for understanding the dramatic changes in the structural organization observed in the basal lamina and apical surface of acini in these patients. The results provide new evidence that acinar and ductal cells from the LSGs of SS patients display a molecular potential, with increased capacity to markedly disorganize their ECM environment and, thus, damage their architecture and functionality.

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Neuropeptides of the autonomic nervous system in Sjogren's syndrome

Cited by 39 publications

References 22 publications

Salivary VIP concentrations are elevated in humans after acute stress

Salivary VIP concentrations are elevated in humans after acute stress

Alterations of Tear Neuromediators in Dry Eye Disease

Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjögren's syndrome patients: Correlation with reduced structural integrity of acini and ducts

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