Salivary VIP concentrations are elevated in humans after acute stress

Ventre, Giovanni; Colonna, Caitlin; Smith, Jennifer; Alfano, Denise L.; Moldow, Roberta L.

doi:10.1016/j.peptides.2013.08.014

Cited by 6 publications

(4 citation statements)

References 93 publications

(179 reference statements)

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“…However, responses to stimuli differ from one gland to another, and the co-existence of different secretory pathways imposes additional variables [4]. Recent work has shown that the increased sympathetic stimulus induced by physical exercise can further modulate the roster of proteins secreted from salivary glands [9,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Physical exercise stimulates salivary secretion of cystatins

et al. 2019

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Physical exercise is known to activate the sympathetic nervous system, which influences the production of saliva from salivary glands. Our examination of saliva collected from highly trained athletes before and after a number of physical competititions showed an increase in the secretion of S-type cystatins and cystatin C as a subacute response to aerobic and anaerobic exercise. The elevation in salivary cystatins was transient and the recovery time course differed from that of amylase and other salivary proteins. An in vitro assay was developed based on a cell line from a human submandibular gland (HSG) that differentiated into acinus-like structures. Treatments with the β-adrenergic agonist isoproterenol caused a shift in the intracellular distribution of S-type cystatins and cystatin C, promoting their accumulation at the outer regions of the acinus prior to release and suggesting the activation of a directional transport involving co-migration of both molecules. In another treatment using non-differentiated HSG cells, it was evident that both expression and secretion of cystatin C increased upon addition of the β-adrenergic agonist, and these effects were essentially eliminated by the antagonist propranolol. The HSG cell line appears to have potential as a model for exploring the mechanism of cystatin secretion, particularly the S-type cystatins that originate primarily in the submandibular glands.

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Section: Introductionmentioning

confidence: 99%

Physical exercise stimulates salivary secretion of cystatins

et al. 2019

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“…Active transportation plays a crucial role in maintaining overall health. Regular exercise associated with active transportation activates the sympathetic nervous system and stimulates saliva production while regulating the secretion of various proteins from salivary glands [23][24][25][26] such as an increase in the concentration of S-type cystatins and cystatin C [27]. These cystatins in saliva help inhibit bacterial adhesion within the oral cavity by obstructing the binding of bacteria to buccal epithelial cells and inhibiting the growth of periodontopathic organisms without suppressing protease activity [28,29].…”

Section: Active Transportation and Oral Healthmentioning

confidence: 99%

Decarbonization of Transport and Oral Health

Foláyan

Tantawi

2023

BioMed

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The decarbonization of transport is a global initiative aimed at reducing greenhouse gas emissions and addressing the risks of global warming. This article explores the potential connections between the decarbonization of transport and oral health, highlighting the need for further research in this area. Emissions from vehicle exhausts, such as carbon dioxide, methane, and nitrous oxide, may have a modest impact on the risk of early childhood caries and other oral health diseases like periodontal diseases, oral cancer, and dental caries. Active transportation, which promotes regular exercise, has beneficial effects on overall health, including stimulating salivary protein production and reducing the risk of diabetes and cardiovascular diseases, both of which are linked to poor oral health. Transitioning to electric vehicles can also reduce noise pollution, positively impacting mental well-being, which is associated with improved oral hygiene practices. Furthermore, the development of sustainable infrastructure, including efficient public transportation systems, can enhance access to dental services. Further research is needed to establish stronger evidence for these connections and to explore how the global decarbonization of transport agenda can incorporate oral health considerations.

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“…All these aspects should be carefully controlled in the design of the food perception studies ages [40][41][42], sex [43], and health status [44]. Moreover, the salivary composition and secretion change in the same individual during the day and display circadian variation [45][46][47][48][49], just as it may change owing to physical activity [48,[50][51][52][53][54][55][56][57], and depend on the diet [58][59][60]. In view of the influences of the aforementioned factors, the perception of food during oral processing is determined not only by the salivation, which is adjusted in response to a specific food product, but also by the composition of unstimulated saliva.…”

Section: Saliva Types and Salivationmentioning

confidence: 99%

A secret of salivary secretions: Multimodal effect of saliva in sensory perception of food

Khramova

Popov

2021

European J Oral Sciences

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Saliva plays multifunctional roles in oral cavity. Even though its importance for the maintenance of oral health has long been established, the role of saliva in food perception has attracted increasing attention in recent years. We encourage researchers to discover the peculiarity of this biological fluid and aim to combine the data concerning all aspects of the saliva influence on the sensory perception of food. This review presents saliva as a unique material, which modulates food perception due to constant presence of saliva in the mouth and thanks to its composition. Therefore, we highlight the salivary components that contribute to these effects. Moreover, this review is an attempt to structure the effects of saliva on perception of different food categories, where the mechanisms of salivary impact in perception of liquid, semi-solid, and solid foods are revealed. Finally, we emphasize that the large interindividual variability in salivary composition and secretion appear to contribute to the fact that everyone experiences food in their own way. Therefore, the design of the sensory studies should consider the properties of volunteers' saliva and also carefully monitor the experimental conditions that affect salivary composition and flow rate.

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Salivary VIP concentrations are elevated in humans after acute stress

Cited by 6 publications

References 93 publications

Physical exercise stimulates salivary secretion of cystatins

Physical exercise stimulates salivary secretion of cystatins

Decarbonization of Transport and Oral Health

A secret of salivary secretions: Multimodal effect of saliva in sensory perception of food

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