Neuropeptides and peptide hormones identified in codling moth, <i>Cydia pomonella</i> (Lepidoptera: Tortricidae)

Garczynski, Stephen F.; Hendrickson, Christopher; Harper, Artemus; Unruh, Thomas R.; Dhingra, Amit; Ahn, Seung‐Joon; Choi, Man‐Yeon

doi:10.1002/arch.21587

Cited by 5 publications

(4 citation statements)

References 56 publications

(84 reference statements)

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“…As ancient molecules, neuropeptides and peptide hormones mediate cell-to-cell communication in all multicellular animals (Li et al, 2008 ; Garczynski et al, 2019 ). To date, many neuropeptides have been identified and sequenced in several insect species (Yeoh et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of Neuropeptides and Their Receptors in the Ectoparasitoid, Habrobracon hebetor

Xiong

et al. 2020

Front. Physiol.

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Neuropeptides are a group of signal molecules that regulate many physiological and behavioral processes by binding to corresponding receptors, most of which are G-protein-coupled receptors (GPCRs). Using bioinformatic methods, we screened genomic and transcriptomic data of the ectoparasitoid wasp, Habrobracon hebetor, and annotated 34 neuropeptide candidate precursor genes and 44 neuropeptide receptor candidate genes. The candidate neuropeptide genes were found to encode all known insect neuropeptides except allatotropin, neuropeptide F, pigment dispersing factor, and CCHamides. When compared with the endoparasitic wasp Pteromalus puparum and the ectoparasitic wasp Nasonia vitripennis, trissin and FMRFamide were found only in H. hebetor. A similar result held for the neuropeptide receptor genes, for the receptors were found in H. hebetor except the receptors of CCHamides and neuroparsin. Furthermore, we compared and analyzed the differences in neuropeptides in eight Braconidae wasps and identified natalisin in H. hebetor, Diachasma alloeum, Fopius arisanus and Microplitis demolitor, but not in the other wasps. We also analyzed the transcriptome data and qRT-PCR data from different developmental stages and tissues to reveal the expression patterns of the neuropeptides and their receptors. In this study, we revealed composition of neuropeptides and neuropeptide receptors in H. hebetor, which may contribute to future neurobiological studies.

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Section: Discussionmentioning

confidence: 99%

Identification of Neuropeptides and Their Receptors in the Ectoparasitoid, Habrobracon hebetor

Xiong

et al. 2020

Front. Physiol.

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“…The basal superfamilies (mentioned above), on the other hand, all contain the octapeptide Peram-CAH-II, or the novel peptide predicted for E. japonica which differs from Peram-CAH-II at position 6 by a Ser instead of a Pro residue and in the chain length (octa-versus decapeptide). Peram-CAH-II is a peptide well-known from blattid cockroaches (order: Blattodea), from certain Caelifera (order: Orthoptera), Heteroptera (order: Hemiptera), and Chrysomeloidea (order: Coleoptera) (Gäde, 2009;Gäde et al, 2019) and recently, amplified and sequenced after data mining the codling moth transcriptome (Garczynski et al, 2019). From the superfamily Yponomeutoidea onward, Supplementary Figure 4D) from Chilo partellus.…”

Section: Akhs Of Lepidoptera Are (Almost) Exclusively Order-specificmentioning

confidence: 99%

Unique Members of the Adipokinetic Hormone Family in Butterflies and Moths (Insecta, Lepidoptera)

2020

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Lepidoptera is amongst one of the four most speciose insect orders and ecologically very successful because of their ability to fly. Insect flight is always aerobic and exacts a high metabolic demand on the animal. A family of structurally related neuropeptides, generically referred to as adipokinetic hormones (AKHs), play a key role in triggering the release of readily utilizable fuel metabolites into the hemolymph from the storage forms in the fat body. We used mass spectrometry to elucidate AKH sequences from 34 species of Lepidoptera and searched the literature and publicly available databases to compile (in a phylogenetic context) a comprehensive list of all Lepidoptera sequences published/predicted from a total of 76 species. We then used the resulting set of 15 biochemically characterized AKHs in a physiological assay that measures lipid or carbohydrate mobilization in three different lepidopteran species to learn about the functional cross-activity (receptor-ligand interactions) amongst the different butterfly/moth families. Our results include novel peptide structures, demonstrate structural diversity, phylogenetic trends in peptide distribution and order-specificity of Lepidoptera AKHs. There is almost an equal occurrence of octa-, nona-, and decapeptides, with an unparalleled emphasis on nonapeptides than in any insect order. Primitive species make Peram-CAH-II, an octapeptide found also in other orders; the lepidopteran signature peptide is Manse-AKH. Not all of the 15 tested AKHs are active in Pieris brassicae; this provides insight into structure-activity specificity and could be useful for further investigations into possible biorational insecticide development.

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“…Neuropeptides and peptide hormones belong to the signalling molecules that control cellular communication in all multicellular organisms (Garczynski et al 2019 ). Neuropeptide production begins with the synthesis of an inactive precursor molecule in the endoplasmic reticulum.…”

Section: Neuropeptidesmentioning

confidence: 99%

Prevention of tick-borne diseases: challenge to recent medicine

Hromníková

Furka

et al. 2022

Biologia

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Ticks represent important vectors and reservoirs of pathogens, causing a number of diseases in humans and animals, and significant damage to livestock every year. Modern research into protection against ticks and tick-borne diseases focuses mainly on the feeding stage, i.e. the period when ticks take their blood meal from their hosts during which pathogens are transmitted. Physiological functions in ticks, such as food intake, saliva production, reproduction, development, and others are under control of neuropeptides and peptide hormones which may be involved in pathogen transmission that cause Lyme borreliosis or tick-borne encephalitis. According to current knowledge, ticks are not reservoirs or vectors for the spread of COVID-19 disease. The search for new vaccination methods to protect against ticks and their transmissible pathogens is a challenge for current science in view of global changes, including the increasing migration of the human population. Highlights • Tick-borne diseases have an increasing incidence due to climate change and increased human migration • To date, there is no evidence of transmission of coronavirus COVID-19 by tick as a vector • To date, there are only a few modern, effective, and actively- used vaccines against ticks or tick-borne diseases • Neuropeptides and their receptors expressed in ticks may be potentially used for vaccine design

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Neuropeptides and peptide hormones identified in codling moth, Cydia pomonella (Lepidoptera: Tortricidae)

Cited by 5 publications

References 56 publications

Identification of Neuropeptides and Their Receptors in the Ectoparasitoid, Habrobracon hebetor

Identification of Neuropeptides and Their Receptors in the Ectoparasitoid, Habrobracon hebetor

Unique Members of the Adipokinetic Hormone Family in Butterflies and Moths (Insecta, Lepidoptera)

Prevention of tick-borne diseases: challenge to recent medicine

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