Identification of Neuropeptides and Their Receptors in the Ectoparasitoid, Habrobracon hebetor

Yu, Kaili; Xiong, Shijiao; Xu, Gang; Ye, Xinhai; Yao, Hongwei; Wang, Fang; Fang, Qi; Song, Qisheng; Yè, Gōngyín

doi:10.3389/fphys.2020.575655

Cited by 14 publications

(19 citation statements)

References 79 publications

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“…Thus, no LK precursor was detected in the “model Coleopteran” Tribolium castaneum . LK precursors and receptors are missing also in, for example, some parasitic wasps (e.g., Nasonia vitripennis ), but not in all [ 63 , 64 ], and were not found in any ant species analyzed to date [ 65 , 66 , 67 ]. An LK precursor is also missing in the phyllopod crustacean Daphnia [ 68 ], although they are present in decapod crustaceans (see [ 69 ]).…”

Section: Leucokinins and Their Receptors In Invertebratesmentioning

confidence: 99%

“…In insects, LKs are multifunctional neuropeptides that share a common C-terminal pentapeptide sequence FX 1 X 2 WGamide, where X 1 can be H, N, S, A, or Y and X 2 can be S, P, A, or R (see Figure 1 B); this pentapeptide is also the active core of LKs, facilitating peptide design [ 40 , 152 , 156 ]. As noted in a previous section, LKs have been identified a wide range of insects (see the DINeR database: ), with the exception of most beetles (Coleoptera), all ants, and some wasps (Hymenoptera) [ 60 , 62 , 63 , 64 , 65 , 67 ]. Since LKs are rapidly degraded by peptidases, analogs of insect LKs have been synthesized with a modified chemical structure to increase stability [ 152 , 156 ].…”

Section: Targeting the Lk Signaling System With Peptide Analogs Tomentioning

confidence: 99%

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Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Nässel

2021

IJMS

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Leucokinins (LKs) constitute a neuropeptide family first discovered in a cockroach and later identified in numerous insects and several other invertebrates. The LK receptors are only distantly related to other known receptors. Among insects, there are many examples of species where genes encoding LKs and their receptors are absent. Furthermore, genomics has revealed that LK signaling is lacking in several of the invertebrate phyla and in vertebrates. In insects, the number and complexity of LK-expressing neurons vary, from the simple pattern in the Drosophila larva where the entire CNS has 20 neurons of 3 main types, to cockroaches with about 250 neurons of many different types. Common to all studied insects is the presence or 1–3 pairs of LK-expressing neurosecretory cells in each abdominal neuromere of the ventral nerve cord, that, at least in some insects, regulate secretion in Malpighian tubules. This review summarizes the diverse functional roles of LK signaling in insects, as well as other arthropods and mollusks. These functions include regulation of ion and water homeostasis, feeding, sleep–metabolism interactions, state-dependent memory formation, as well as modulation of gustatory sensitivity and nociception. Other functions are implied by the neuronal distribution of LK, but remain to be investigated.

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Section: Leucokinins and Their Receptors In Invertebratesmentioning

confidence: 99%

Section: Targeting the Lk Signaling System With Peptide Analogs Tomentioning

confidence: 99%

Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Nässel

2021

IJMS

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“…In insects LKs are multifunctional neuropeptides which share a common C-terminal pentapeptide sequence FX1X2WGamide, where X1 can be H, N, S, A or Y and X2 can be S, P, A or R (see Figure 1B); this pentapeptide is also the active core of LKs, facilitating peptide design [40,148,152]. As noted in a previous section, LKs have been identified a wide range of insects (see the DINeR database: http://www.neurostresspep.eu/diner/infosearch), with the exception of most beetles (Coleoptera), all ants and some wasps (Hymenoptera) [57,[59][60][61][62]64]. Since LKs are rapidly degraded by peptidases, analogs of insect LKs have been synthesized with a modified chemical structure to increase stability [148,152].…”

Section: Targeting the Lk Signaling System With Peptide Analogs To Aimentioning

confidence: 81%

“…Thus, no LK precursor was detected in the "model Coleopteran" Tribolium castaneum. LK precursors and receptors are missing also in for example some parasitic wasps (e. g. Nasonia vitripennis), but not in all [60,61], and were not found in any ant species analyzed to date [62][63][64]. An LK precursor is also missing in the phyllopod crustacean Daphnia [65], although they are present in decapod crustaceans [see [66]].…”

Section: Leucokinins and Their Receptors In Insects And Other Invertementioning

confidence: 99%

Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Nässel¹,

Wu²

2021

Preprint

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Leucokinins (LKs) constitute a neuropeptide family first discovered in a cockroach and later identified in numerous insects and several other invertebrates. The LK receptors are only distantly related to other known receptors. Among insects, there are many examples of species where genes encoding LKs and their receptors are absent. Furthermore, genomics has revealed that LK signaling is lacking in several of the invertebrate phyla and in vertebrates. In insects, the number and complexity of LK expressing neurons vary, from the simple pattern in the larva of Drosophila where the entire CNS has 20 neurons of three main types, to cockroaches with about 250 of many different types. Common to all studied insects is the presence or 1-3 pairs of LK-expressing neurosecretory cells in each abdominal neuromere of the ventral nerve cord, that, at least in some insects, regulate secretion in Malpighian tubules. This review summarizes the diverse functional roles of LK signaling in insects, as well as other arthropods and mollusks. These functions include regulation of ion and water homeostasis, feeding, sleep-metabolism interactions, state-dependent memory formation, as well as modulation of gustatory sensitivity and nociception. Other functions are implied by the neuronal distribution of LK, but remain to be investigated.

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“…Meanwhile, the conservation of these pesticides target genes between target pests and beneficial insects should also be considered to avoid adverse side effects on these beneficial insects [1,24]. Thus, genetic information about neuropeptides and their corresponding receptors in beneficial insects are needed [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Identification of Neuropeptides and Their Receptors in an Aphid Endoparasitoid Wasp, Aphidius gifuensi

Xue

Gao

et al. 2021

Insects

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In insects, neuropeptides and their receptors not only play a critical role in insect physiology and behavior but also are the potential targets for novel pesticide discoveries. Aphidius gifuensis is one of the most important and widespread aphid parasitoids, and has been successfully used to control aphid. In the present work, we systematically identified neuropeptides and their receptors from the genome and head transcriptome of A. gifuensis. A total of 35 neuropeptide precursors and 49 corresponding receptors were identified. The phylogenetic analyses demonstrated that 35 of these receptors belong to family-A, four belong to family-B, two belong to leucine-rich repeat-containing GPCRs, four belong to receptor guanylyl cyclases, and four belong to receptor tyrosine kinases. Oral ingestion of imidacloprid significantly up-regulated five neuropeptide precursors and four receptors whereas three neuropeptide precursors and eight receptors were significantly down-regulated, which indicated that these neuropeptides and their receptors are potential targets of some commercial insecticides. The RT-qPCR results showed that dopamine receptor 1, dopamine receptor 2, octopamine receptor, allatostatin-A receptor, neuropeptides capa receptor, SIFamide receptor, FMRFamide receptor, tyramine receptor and short neuropeptide F predominantly were expressed in the head whilst the expression of ion transport peptide showed widespread distribution in various tissues. The high expression levels of these genes suggest their important roles in the central nervous system. Taken together, our study provides fundamental information that may further our understanding of neuropeptidergic signaling systems in the regulation of the physiology and behavior of solitary wasps. Furthermore, this information could also aid in the design and discovery of specific and environment-friendly insecticides.

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Identification of Neuropeptides and Their Receptors in the Ectoparasitoid, Habrobracon hebetor

Cited by 14 publications

References 79 publications

Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Genome-Wide Identification of Neuropeptides and Their Receptors in an Aphid Endoparasitoid Wasp, Aphidius gifuensi

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