Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Nässel, Dick R.; Wu, Shun‐Fan

doi:10.3390/ijms22041531

Cited by 8 publications

(15 citation statements)

References 171 publications

(428 reference statements)

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“…In D. melanogaster, DH44 expression was detected at low levels during embryonal development, increasing by the third larval instar and remaining elevated in the pupal brain and adult ventral nerve chord (Cannell et al, 2016). In the bug Rhodnius prolixus, DH44 is released into the hemolymph following feeding (Nässel and Wu, 2021). Glycoprotein B5 (GPB5) has been shown to regulate the reabsorption of sodium in the hindgut of the mosquito, Aedes aegypti (Paluzzi et al, 2014) .…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis and Time to Hatch Visual Prediction of Embryo Development in the Ornate Spiny Lobster (Panulirus ornatus)

et al. 2022

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The ability to conduct closed life-cycle culture of tropical spiny lobsters, Panulirus ornatus, at the Institute for Marine and Antarctic Studies (IMAS) provides a unique opportunity to investigate specific developmental stages during embryogenesis. The production of closed life-cycle lobsters provides access to embryos at defined time points, yet physical staging is challenging due to their small size and environmental factors impacting their development. A transcriptome comprising 11 distinct stages across the 30-day P. ornatus embryonal development period allowed the establishment of the most detailed transcriptomic library of embryogenesis across decapods. A series of key genes across the 11 stages of embryonal development were characterized. The expression of neuropeptides was reported across P. ornatus embryos, suggesting they are primarily active during the later stages of embryogenesis as the nervous system develops and the animal prepares to hatch. Gastrula-specific genes, nanos and brachyury, presented an expression profile indicating gastrulation occurs early in embryogenesis. In addition to the molecular tools used to characterize embryo development, certain developmental characteristics, such as eye spot development, provide a measurable indicator that can be visualised. Hatch prediction models based on visual characteristics were shown to be an accurate method to predict the timing of the hatch for P. ornatus embryos kept at 26°C. The combination of morphological and visual measures with transcriptomics can be used to further define and establish the groundwork for future characterisation and staging of P. ornatus embryogenesis.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis and Time to Hatch Visual Prediction of Embryo Development in the Ornate Spiny Lobster (Panulirus ornatus)

et al. 2022

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“…Previously implicated in female-related behavior, the expression levels of prepro-AmTRP are present only in the brain of female bees (queens and workers) and show lower expression levels according to labor division (lower in younger/nurse bees, higher in queens and foragers) [ 47 ]. The tachykinin neuropeptide also controls metabolic and desiccation responses in Drosophila [ 48 , 49 ] and is related to aggression in other insects, such as the Leaf-Cutting Ant Acromyrmex echinatior [ 50 ]. Other AmTRP neuropeptides are implicated in the defensive behavior of Africanized honey bees [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Attack of the dark clones the genetics of reproductive and color traits of South African honey bees (Apis mellifera spp.)

Rosa

Eimanifar²,

Kimes

et al. 2021

PLoS ONE

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The traits of two subspecies of western honey bees, Apis mellifera scutellata and A.m. capensis, endemic to the Republic of South Africa (RSA), are of biological and commercial relevance. Nevertheless, the genetic basis of important phenotypes found in these subspecies remains poorly understood. We performed a genome wide association study on three traits of biological relevance in 234 A.m. capensis, 73 A.m. scutellata and 158 hybrid individuals. Thirteen markers were significantly associated to at least one trait (P ≤ 4.28 × 10−6): one for ovariole number, four for scutellar plate and eight for tergite color. We discovered two possible causative variants associated to the respective phenotypes: a deletion in GB46429 or Ebony (NC_007070.3:g.14101325G>del) (R69Efs*85) and a nonsense on GB54634 (NC_007076.3:g.4492792A>G;p.Tyr128*) causing a premature stop, substantially shortening the predicted protein. The mutant genotypes are significantly associated to phenotypes in A.m. capensis. Loss-of-function of Ebony can cause accumulation of circulating dopamine, and increased dopamine levels correlate to ovary development in queenless workers and pheromone production. Allelic association (P = 1.824 x 10−5) of NC_007076.3:g.4492792A>G;p.Tyr128* to ovariole number warrants further investigation into function and expression of the GB54634 gene. Our results highlight genetic components of relevant production/conservation behavioral phenotypes in honey bees.

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“…This is in contrast to many other neuropeptides that are found both in the brain and the gut [85,[175][176][177]. A separate review deals more extensively with distribution and functional roles of LK signaling in other invertebrates [178].…”

Section: Some Aspects Of Lk Signaling In Other Invertebratesmentioning

confidence: 99%

Leucokinin and Associated Neuropeptides Regulate Multiple Aspects of Physiology and Behavior in Drosophila

Nässel

2021

IJMS

Self Cite

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Leucokinins (LKs) constitute a family of neuropeptides identified in numerous insects and many other invertebrates. LKs act on G-protein-coupled receptors that display only distant relations to other known receptors. In adult Drosophila, 26 neurons/neurosecretory cells of three main types express LK. The four brain interneurons are of two types, and these are implicated in several important functions in the fly’s behavior and physiology, including feeding, sleep–metabolism interactions, state-dependent memory formation, as well as modulation of gustatory sensitivity and nociception. The 22 neurosecretory cells (abdominal LK neurons, ABLKs) of the abdominal neuromeres co-express LK and a diuretic hormone (DH44), and together, these regulate water and ion homeostasis and associated stress as well as food intake. In Drosophila larvae, LK neurons modulate locomotion, escape responses and aspects of ecdysis behavior. A set of lateral neurosecretory cells, ALKs (anterior LK neurons), in the brain express LK in larvae, but inconsistently so in adults. These ALKs co-express three other neuropeptides and regulate water and ion homeostasis, feeding, and drinking, but the specific role of LK is not yet known. This review summarizes Drosophila data on embryonic lineages of LK neurons, functional roles of individual LK neuron types, interactions with other peptidergic systems, and orchestrating functions of LK.

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Leucokinins: Multifunctional Neuropeptides and Hormones in Insects and Other Invertebrates

Cited by 8 publications

References 171 publications

Transcriptomic Analysis and Time to Hatch Visual Prediction of Embryo Development in the Ornate Spiny Lobster (Panulirus ornatus)

Transcriptomic Analysis and Time to Hatch Visual Prediction of Embryo Development in the Ornate Spiny Lobster (Panulirus ornatus)

Attack of the dark clones the genetics of reproductive and color traits of South African honey bees (Apis mellifera spp.)

Leucokinin and Associated Neuropeptides Regulate Multiple Aspects of Physiology and Behavior in Drosophila

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