Neuropeptides and hippocampal neurogenesis

Zaben, Malik; Gray, William Peter

doi:10.1016/j.npep.2013.10.002

Cited by 67 publications

(50 citation statements)

References 111 publications

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“…GAL mRNA is also detected in the proliferative zones of both the developing and adult brains-the subventricular zone, the rostral migratory stream, and the subgranular zone of the hippocampus -where it may regulate the proliferation, differentiation, and/or migration of neural stem cells (Xia et al, 2005a;Agasse et al, 2013;Mansouri et al, 2013;Zaben and Gray, 2013) (see sections V.D and VIII)-and in oligodendrocyte precursor cells in the corpus callosum Ubink et al, 2003), suggesting a role for galanin in normal myelination and responses to myelin injury (see Wraith et al, 2009, andZhang et al, 2012).…”

Section: Galanin Family Peptide and Galanin Receptor Distributionsmentioning

confidence: 99%

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

et al. 2014

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Section: Galanin Family Peptide and Galanin Receptor Distributionsmentioning

confidence: 99%

Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

et al. 2014

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“…SVs contain neurotransmitters responsible for fast signaling (Kaeser and Regehr, 2014, Rizo and Sudhof, 2012, Sudhof and Rothman, 2009), whereas DCVs store neuromodulators such as neuropeptides and neurotrophins that regulate brain development, synaptogenesis, and synaptic plasticity (Huang and Reichardt, 2001, Park and Poo, 2013, van den Pol, 2012, Zaben and Gray, 2013). While SVs recycle locally in nerve terminals, DCVs are filled with cargo at the trans -Golgi network (TGN).…”

Section: Introductionmentioning

confidence: 99%

Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons

et al. 2017

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SummaryNeurons communicate by regulated secretion of chemical signals from synaptic vesicles (SVs) and dense-core vesicles (DCVs). Here, we investigated the maturation of these two secretory pathways in micro-networks of human iPSC-derived neurons. These micro-networks abundantly expressed endogenous SV and DCV markers, including neuropeptides. DCV transport was microtubule dependent, preferentially anterograde in axons, and 2-fold faster in axons than in dendrites. SV and DCV secretion were strictly Ca2+ and SNARE dependent. DCV secretion capacity matured until day in vitro (DIV) 36, with intense stimulation releasing 6% of the total DCV pool, and then plateaued. This efficiency is comparable with mature mouse neurons. In contrast, SV secretion capacity continued to increase until DIV50, with substantial further increase in secretion efficiency and decrease in silent synapses. These data show that the two secretory pathways can be studied in human neurons and that they mature differentially, with DCV secretion reaching maximum efficiency when that of SVs is still low.

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“…Amongst those, galanin (GAL) has been introduced already some decades ago (Tatemoto et al, 1983), consisting of 29 aminoacids, (30 aminoacids in humans) and found in many species (Lang et al, 2015) in the central as well as peripheral nervous system. Galanin takes part in many aspects of autonomic control (Jobling, 2011;Shanks and Herring, 2013;von Rosenvinge and Raufman, 2010), and it is a key player in developmental processes (Zaben and Gray, 2013). It is also involved in many pathological conditions, including Alzheimer's disease and some forms of epilepsia as well as cerebral ischemia/stroke and several forms of psychiatric disorders (for review see (Lang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%