Neuropeptides, amines and amino acids in an elementary insect ganglion: Functional and chemical anatomy of the unfused abdominal ganglion

Nässel, Dick R.

doi:10.1016/0301-0082(95)00048-8

Cited by 120 publications

(72 citation statements)

References 493 publications

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“…21 Gr-GAL4 drivers show abdominal ganglion projection The brain and thoracic-abdominal ganglia compose the Drosophila central nervous system, and the abdominal ganglion (AG) is a likely CNS target of neurons innervating abdominal organs (Nassel, 1996;Stocker, 1994). When the 67 drivers were examined, 21 were observed to have GFP-positive neuronal projections to the AG (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The abdominal ganglion is an organ in insects that regulates functions such as respiration, heartbeat, hindgut movement, abdominal posture, and functions of the genitalia and ovipositor (Nassel, 1996). In studies on Drosophila ovulation, female postmating behavior, and male courtship or reproductive behavior (Hasemeyer et al, 2009;Lee et al, 2001;Monastirioti, 2003;Yang et al, 2009), abdominal peripheral neurons were observed to directly project to the abdominal ganglion to mediate diverse functions.…”

Section: Discussionmentioning

confidence: 99%

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A Systematic Analysis of Drosophila Gustatory Receptor Gene Expression in Abdominal Neurons which Project to the Central Nervous System

Park

Kwon

2011

Molecules and Cells

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Systematic Analysis of Drosophila Gustatory Receptor Gene Expression in Abdominal Neurons which Project to the Central Nervous System

Park

Kwon

2011

Molecules and Cells

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“…A small subset of these cells (~150) are peptidergic, as defined by expression of high levels of neuropeptide-processing enzymes and one or several of the ~30 identified neuropeptides (Hewes et al, 2003;Nassel, 1996;Taghert, 1999). The neuropeptide gene FMRFamide-related (Fmrf) is expressed in a small subset of embryonic/larval peptidergic VNC neurons, the six Tv cells located bilaterally in the three thoracic segments (blue cells in Fig.…”

Section: Resultsmentioning

confidence: 99%

Independent roles of thedachshundandeyes absentgenes in BMP signaling, axon pathfinding and neuronal specification

2004

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In the Drosophila nerve cord, a subset of neurons expresses the neuropeptide FMRFamide related (Fmrf). Fmrf expression is controlled by a combinatorial code of intrinsic factors and an extrinsic BMP signal. However, this previously identified code does not fully explain the regulation of Fmrf. We have found that the Dachshund (Dac) and Eyes Absent (Eya)transcription co-factors participate in this combinatorial code. Previous studies have revealed an intimate link between Dac and Eya during eye development. Here, by analyzing their function in neurons with multiple phenotypic markers, we demonstrate that they play independent roles in neuronal specification, even within single cells. dac is required for high-level Fmrf expression, and acts potently together with apterous and BMP signaling to trigger Fmrf expression ectopically, even in motoneurons. By contrast, eya regulates Fmrf expression by controlling both axon pathfinding and BMP signaling, but cannot trigger Fmrf ectopically. Thus, we show that dac and eya perform entirely different functions in a single cell type to ultimately regulate a single phenotypic outcome.

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“…For example, glutamate is the major excitatory neurotransmitter at insect motor neurons and has both inhibitory and excitatory roles in interneurons (see Nassel, 1996). Dopaminergic neurons in the abdominal ganglion of insects are typically sparsely distributed but show large branching patterns, indicative of neuromodulatory effects (Nassel, 1996). Specific examples of these effects have been documented for flight control in Manduca sexta (Claassen & Kammer, 1986) and escape response in the cockroach, Leucophaea maderae (Casagrand & Ritzmann, 1992).…”

Section: Invertebrate Foraging and Feeding Behaviormentioning

confidence: 99%

“…The co-occurrence of dopamine and glutamate in modulatory relations is a common feature across eumetazoan clades (Acerbo, Gargiulo, Krug, & Delius, 2002;Cleland & Selverston, 1997;Fienberg et al, 1998;. For example, glutamate is the major excitatory neurotransmitter at insect motor neurons and has both inhibitory and excitatory roles in interneurons (see Nassel, 1996). Dopaminergic neurons in the abdominal ganglion of insects are typically sparsely distributed but show large branching patterns, indicative of neuromodulatory effects (Nassel, 1996).…”

Section: Invertebrate Foraging and Feeding Behaviormentioning

confidence: 99%

Animal Foraging and the Evolution of Goal‐Directed Cognition

2006

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Foraging-and feeding-related behaviors across eumetazoans share similar molecular mechanisms, suggesting the early evolution of an optimal foraging behavior called area-restricted search (ARS), involving mechanisms of dopamine and glutamate in the modulation of behavioral focus. Similar mechanisms in the vertebrate basal ganglia control motor behavior and cognition and reveal an evolutionary progression toward increasing internal connections between prefrontal cortex and striatum in moving from amphibian to primate. The basal ganglia in higher vertebrates show the ability to transfer dopaminergic activity from unconditioned stimuli to conditioned stimuli. The evolutionary role of dopamine in the modulation of goal-directed behavior and cognition is further supported by pathologies of human goal-directed cognition, which have motor and cognitive dysfunction and organize themselves, with respect to dopaminergic activity, along the gradient described by ARS, from perseverative to unfocused. The evidence strongly supports the evolution of goal-directed cognition out of mechanisms initially in control of spatial foraging but, through increasing cortical connections, eventually used to forage for information.

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Neuropeptides, amines and amino acids in an elementary insect ganglion: Functional and chemical anatomy of the unfused abdominal ganglion

Cited by 120 publications

References 493 publications

A Systematic Analysis of Drosophila Gustatory Receptor Gene Expression in Abdominal Neurons which Project to the Central Nervous System

A Systematic Analysis of Drosophila Gustatory Receptor Gene Expression in Abdominal Neurons which Project to the Central Nervous System

Independent roles of thedachshundandeyes absentgenes in BMP signaling, axon pathfinding and neuronal specification

Animal Foraging and the Evolution of Goal‐Directed Cognition

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