Neuropeptide Y-Immunoreactive Neurons in the Retina of Two Australian Lizards.

Straznicky, Charles; Hiscock, Jennifer

doi:10.1679/aohc.57.151

Cited by 9 publications

(11 citation statements)

References 18 publications

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“…91 Lizard retina show NPY-immunoreactivity in amacrine cells in INL, and are sporadically displaced at GCL. 92 Turtle retina shows NPY-ir in bipolar cells and amacrine cells, evenly distributed in the retina (in INL, IPL, and GCL and located in peripheral retina). 21,93 Furthermore, frogs have the highest concentration of NPY-ir levels, which are characterized by seasonal variations 7 ; NPY-immunoreactivity is localized in a small population of amacrine cell bodies in INL, 6,12,22,94 in bipolar-like cell bodies of INL, in GCL, in Müller cells within in INL 22 and in various processes in IPL.…”

Section: Discussionmentioning

confidence: 99%

Neuropeptide Y Receptors Y₁and Y₂are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture

Santos-Carvalho

Aveleira²,

Elvas

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Neuropeptide Y (NPY) is one of the most abundant peptides in the central nervous system (CNS), including the retina. This peptide activates various different G-coupled receptors (NPY Y 1 , Y 2 , Y 4 , and Y 5 ) that are also present in the retina. However, the localization of NPY receptors in the several types of retinal cells is not completely known. In this study, we have looked at the distribution of NPY Y 1 and Y 2 receptors in rat retinal cells to reveal new perspectives on the role of NPY receptors in retina physiology. METHODS.Rat retinal neural cell cultures were prepared from newborn Wistar rats (P3-P5) and pure rat Müller cell culture was obtained after treatment of these cells with ascorbic acid. 1 This 36-amino acid peptide was first isolated from the pig brain in 1982 by Tatemoto.2 NPY is one of the most abundant peptides in the central nervous system (CNS), including the retina, and is involved in numerous physiologic functions, such as feeding, memory processing, and cognition.3,4 NPY actions are mediated by G protein-coupled receptors, which have been named NPY Y 1 , Y 2 , Y 4 , Y 5 , and y 6 . 3,5 NPY is expressed in the retina of mammals and nonmammals. [6][7][8][9][10][11][12] In rodent retinas, NPY-immunoreactivity (NPY-ir) is present in the inner retina, it is localized in cell bodies at both inner nuclear layer (INL) and ganglion cell layer (GCL), and is also present in processes located in the inner plexiform layer (IPL).11,13 NPY shows one of the highest degrees of phylogenetic preservation, compared with other neuropeptides, and does not show marked differences between species.14,16 From a consideration of the phylogenetic preservation, it is expected that the NPY and NPY receptor distribution in the retina does not vary significantly between species. NPY-ir is present in amacrine cells in the majority of species studied (fish, frogs, lizards, rodents, baboons, pigs, cats, chickens, and pigeons). Cats, dogs, dolphins, and humans also show NPY in their ganglion cells, 9,17-20 while some turtles, lizards, and frogs present NPY-ir in bipolar cells. 8,21,22 Few studies have analyzed the distribution of NPY receptors either in the retina or in specific retinal cell types. The presence of both Y 1 and Y 2 receptors in the mouse retina has been confirmed by mRNA analysis 13,23 ; however, it is unclear which cell types express these receptors. Moreover, in primary cultures of Müller cells isolated from the retina of guinea pig, a functional assay of cell proliferation suggested the presence of NPY Y 1 receptor in these glial cells. 24 In human retinal pigment epithelium (RPE), mRNA encoding for NPY Y 1 , Y 2 , and Y 5 receptors has been detected, while in bovine RPE only mRNAs encoding for NPY Y 1 and Y 2 receptors have been found. 25 Although the presence of NPY receptors in the rat retina has been described, in particular in NPY Y 1 , Y 2 , Y 4 , and Y 5 mRNA expression, 26,27 little is known about their localization. The NPY Y 1 receptor-ir is localized in horizontal and amacrine ce...

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Section: Discussionmentioning

confidence: 99%

Neuropeptide Y Receptors Y₁and Y₂are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture

Santos-Carvalho

Aveleira²,

Elvas

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…On the one hand, these neurons are considered as "displaced amacrine cells" because of their morphology and localization (Tornqvist and Ehinger 1988;Straznicky and Hiscock 1994). On the other hand, ganglion cells also contain immunoreactive NPY and give rise to NPY-immunoreactive axons projecting to various brain areas, e.g., the superior collicles (Straznicky and Hiscock 1989;Hutsler et al 1993).…”

Section: Discussionmentioning

confidence: 99%

Comparative investigations of the neuronal apparatus in the pineal organ and retina of the rainbow trout: immunocytochemical demonstration of neurofilament 200-kDa and neuropeptide Y, and tracing with DiI

Blank

Müller

Korf

1997

Cell and Tissue Research

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The retina and pineal organ of the rainbow trout have been investigated immunocytochemically with antibodies against neurofilament 200-kDa (NF-200) and neuropeptide Y (NPY), which are known to label horizontal and amacrine cells in the retina of several vertebrates. The NF-200 immunoreaction stains horizontal cells of the retina, but not neuronal perikarya in the pineal organ. Axons of both the optic and the pineal tract display immunoreaction for NF. The NPY immunoreaction labels a population of amacrine cells in the retina, but is not detected in neuronal perikarya of the pineal organ. Single NPY-immunoreactive nerve fibers have been located in the capsule of the pineal organ. The data suggest that neurons corresponding to NF-200-immunoreactive horizontal and NPY-immunoreactive amacrine cells of the retina are missing from the pineal organ of the trout. Thus, the neuronal apparatus in the light-sensitive pineal organ appears to be less complex than that in the retina. This has been confirmed by tracing experiments with DiI: intrapineal neurons retrogradely labeled via the pineal tract are found in a postsynaptic location to processes of photoreceptor cells containing synaptic ribbons. These results indicate a bineuronal chain in the pineal organ of the rainbow trout comprising the photoreceptor cell as the first neuron and the ganglion cells forming the pineal tract as the second neuron. The NPY-immunoreactive nerve fibers in the capsule of the pineal organ may represent an autonomic innervation.

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“…In lizard (P. vitticeps and V. gouldii) retinas, two types of amacrine cells are described: type A and B. Type A amacrine cells divide their dendrites in sublamina 1 and 2/3 of IPL, while type B are mostly in sublamina 5 (Straznicky and Hiscock, 1994). Thus, in transverse retinal sections three bands of NPY-IR were evident in the IPL of both species.…”

Section: In Contrast Npy Stimulates the Release Of [ 3 H]-glycinementioning

confidence: 97%

“…Type A amacrine cells have large somata than type B, and their dendritic arbor also branch with a different pattern (Straznicky and Hiscock, 1994). The NPY-immunoreactive type A amacrine cells are more common, densely distributed in the INL, but not uniformly distributed across the retina.…”

Section: Horizontal Cellsmentioning

confidence: 99%

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Neuropeptide Y system in the retina: From localization to function

Santos-Carvalho

Ambrósio

Cavadas

2015

Progress in Retinal and Eye Research

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Neuropeptide Y-Immunoreactive Neurons in the Retina of Two Australian Lizards.

Cited by 9 publications

References 18 publications

Neuropeptide Y Receptors Y₁and Y₂are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture

Neuropeptide Y Receptors Y₁and Y₂are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture

Comparative investigations of the neuronal apparatus in the pineal organ and retina of the rainbow trout: immunocytochemical demonstration of neurofilament 200-kDa and neuropeptide Y, and tracing with DiI

Neuropeptide Y system in the retina: From localization to function

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Neuropeptide Y-Immunoreactive Neurons in the Retina of Two Australian Lizards.

Cited by 9 publications

References 18 publications

Neuropeptide Y Receptors Y1and Y2are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture

Neuropeptide Y Receptors Y1and Y2are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture

Comparative investigations of the neuronal apparatus in the pineal organ and retina of the rainbow trout: immunocytochemical demonstration of neurofilament 200-kDa and neuropeptide Y, and tracing with DiI

Neuropeptide Y system in the retina: From localization to function

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Neuropeptide Y Receptors Y₁and Y₂are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture

Neuropeptide Y Receptors Y₁and Y₂are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture