Neuropeptide Y system in the retina: From localization to function

Santos-Carvalho, Ana; Ambrósio, António Francisco; Cavadas, Cláudia

doi:10.1016/j.preteyeres.2015.03.001

Cited by 26 publications

(22 citation statements)

References 193 publications

(318 reference statements)

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“…Most lineages of dengue type 3 carry a predicted mimic pentamer, GEDAP, which matches a pentamer in the mature NPY peptide. This differs from ZIKV, where the conserved pentamer mimic, ESTEN, is in the CPON component of the NPY propeptide [39], as shown in Figure 6. The dengue type 3 GEDAP motif is present in 134 of 277 recent (since 2000) South American dengue type 3 isolates analyzed.…”

Section: Resultsmentioning

confidence: 99%

Antibody mediated epitope mimicry in the pathogenesis of Zika virus related disease

Homan

Malone²,

Darnell

et al. 2016

Preprint

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Section: Resultsmentioning

confidence: 99%

Antibody mediated epitope mimicry in the pathogenesis of Zika virus related disease

Homan

Malone²,

Darnell

et al. 2016

Preprint

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“…31 Moreover, the presence of the NPY system in retinal cells has been reported and was thoroughly reviewed previously. Several studies have reported the localization of NPY in the brain 3 and retina.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported the localization of NPY in the brain 3 and retina. 31 Moreover, the presence of the NPY system in retinal cells has been reported and was thoroughly reviewed previously. 22,31 As the NPY system modulates several cellular functions and has neuroprotective effects, it can be considered as a potentially good candidate for therapies targeting retinal degenerative diseases.…”

Section: Discussionmentioning

confidence: 99%

“…31 Moreover, the presence of the NPY system in retinal cells has been reported and was thoroughly reviewed previously. 22,31 As the NPY system modulates several cellular functions and has neuroprotective effects, it can be considered as a potentially good candidate for therapies targeting retinal degenerative diseases. 31 Several questions remain to be answered concerning the expression and localization of NPY.…”

Section: Discussionmentioning

confidence: 99%

“…22,31 As the NPY system modulates several cellular functions and has neuroprotective effects, it can be considered as a potentially good candidate for therapies targeting retinal degenerative diseases. 31 Several questions remain to be answered concerning the expression and localization of NPY. More importantly, the role and modulation of the NPY system in the retina, under disease conditions, need to be addressed.…”

Section: Discussionmentioning

confidence: 99%

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Impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of rat retina

Campos

Martins

Brudzewsky

et al. 2018

Clinical Exper Ophthalmology

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Localization, distribution, and connectivity of neuropeptide Y in the human and porcine retinas—A comparative study

Christiansen

Kiilgaard

Klemp

et al. 2018

J of Comparative Neurology

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Neuropeptide Y (NPY) is a peptide neurotransmitter abundantly expressed in the mammalian retina. Since its discovery, NPY has been studied in retinas of several species, but detailed characterization of morphology, cell-type, and connectivity has never been conducted in larger mammals including humans and pigs. As the pig due to size and cellular composition is a well-suited animal for retinal research, we chose to compare the endogenous NPY system of the human retina to that of pigs to support future research in this field. In the present study, using immunohistochemistry, confocal microscopy and 3D reconstructions, we found NPY to be expressed in GABAergic and calretinin-immunoreactive (-ir) amacrine cells of both species as well as parvalbumin-ir amacrine cells of humans. Furthermore, we identified at least two different types of medium- to wide-field NPY-ir amacrine cells. Finally, we detected likely synaptic appositions between the NPY-ir amacrine cells and melanopsin- and nonmelanopsin-ir ganglion cells, GABAergic and dopaminergic amacrine cells, rod bipolar cells, and horizontal cells, suggesting that NPY-ir cells play diverse roles in modulation of both image and non-image forming retinal signaling. These findings extend existing knowledge on NPY and NPY-expressing cells in the human and porcine retina showing a high degree of comparability. The extensive distribution and connectivity of NPY-ir cells described in the present study further highlights the potential importance of NPY signaling in retinal function.

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Neuropeptide Y system in the retina: From localization to function

Cited by 26 publications

References 193 publications

Antibody mediated epitope mimicry in the pathogenesis of Zika virus related disease

Antibody mediated epitope mimicry in the pathogenesis of Zika virus related disease

Impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of rat retina

Localization, distribution, and connectivity of neuropeptide Y in the human and porcine retinas—A comparative study

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