Neuropeptide Y effect on food intake in broiler and layer chicks

Saneyasu, Takaoki; Honda, Kazuhisa; Kamisoyama, Hiroshi; Ikura, Atsushi; Nakayama, Yôko; Hasegawa, Shin

doi:10.1016/j.cbpa.2011.04.008

Cited by 43 publications

(31 citation statements)

References 45 publications

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“…1). We previously showed that hypothalamic NPY mRNA level at 1 days of age was higher than that at 8 days of age in chicks (Saneyasu et al, 2011). All our findings suggest that the hypothalamic NPY mRNA level was higher during the first week post-hatching in chicks than that after 14 days of age.…”

Section: Resultssupporting

confidence: 51%

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Age-Dependent Changes in the mRNA Levels of Neuropeptide Y, Proopiomelanocortin, and Corticotropin-Releasing Factor in the Hypothalamus in Growing Broiler Chicks

et al. 2013

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Lines of evidence suggest that hypothalamic neuropeptides have a physiological role in the regulation of food intake in mammals. However, little is known about the age-dependent change of hypothalamic neuropeptides in chicks. In this study, we investigated the age-dependent changes in hypothalamic mRNA levels of neuropeptide Y (NPY, an orexigenic neuropeptide), proopiomelanocortin (POMC, the precursor of anorexigenic neuropeptides), and corticotropin-releasing factor (CRF, a possible mediator in the POMC-induced anorexigenic pathway) in growing broiler chicks. The weights of body and abdominal adipose tissue of chicks were measured at 7, 14, 21, and 28 days of age, and the hypothalamic mRNA levels of NPY, POMC, and CRF were analyzed by real-time PCR. Hypothalamic NPY mRNA levels at 14 and 28 days of age were significantly (P＜0.05) lower than that at 7 days of age. Hypothalamic POMC mRNA level at 28 days of age was significantly lower than that at 7 days of age. Hypothalamic CRF mRNA level was not affected throughout the experimental period. Abdominal adipose tissue weight was significantly increased after 14 days of age in chicks. Our findings demonstrated that the expressions of NPY and POMC are dependent on age in boiler chicken hypothalamus.

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Section: Resultssupporting

confidence: 51%

“…For example, central administration of NPY significantly increases food intake in mammals (Edwards et al, 1999) and chicks (Saneyasu et al, 2011). The mRNA level of NPY in the hypothalamus was increased by fasting in mammals (Bertile et al, 2003) and chicks (Kameda et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Age-Dependent Changes in the mRNA Levels of Neuropeptide Y, Proopiomelanocortin, and Corticotropin-Releasing Factor in the Hypothalamus in Growing Broiler Chicks

et al. 2013

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“…On the basis of genetically differences between layer and broiler breeds, there is evidence claims that food intake regulatory mechanisms are differ between different breeds of chickens. For instance, comparative physiological studies on meat type chicken (broilers) and layer-type (hens) revealed that broiler compared to layers, is higher in feed consumption, basal metabolic rate and energy expenditure possibly due to a genetically altered feed intake control mechanisms [37,38] .…”

Section: Gabamentioning

confidence: 99%

“…Genetic selection for growth in broiler chickens might alter their responsiveness to appetite regulation mechanisms [18,37,38] . As mentioned, there is a neurological interaction between GABA and 5-HT in the brain.…”

Section: Gabamentioning

confidence: 99%

Central regulation of food intake in mammals and birds: a review

Zendehdel

Hassanpour

2015

Neurotransmitter

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Appetite regulates by a complex system of central and peripheral signals which interact in order to modulate ingestion response. A number of peptides comprise a complex network that regulates feeding behavior in vertebrates. This review is focused on the main neurotransmitters and peptides that influence feeding responses in mammals and birds. On the basis of literature review, there are several evidences that neurotransmitters have different effects on food intake between mammals and birds. Also, central regulation of food intake regulates via different mechanisms in animals. So, the aim of this review was to investigate comparative food-intake regulation mechanisms in mammals and birds.

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“…Modern broiler chicks eat more food than layer chicks (Saneyasu et al, 2011), and their overconsumption of food can lead to the excessive accumulation of visceral fat (Richards and Proszkowiec-Weglarz, 2007;Wang et al, 2010). This accumulation is regarded as an animal byproduct or as waste.…”

Section: Introductionmentioning

confidence: 99%

Glucagon and Neuromedin U Suppress Food Intake in Broiler Chicks

et al. 2015

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Several peptides show different effects on food intake between broiler and layer chicks. For example, the central administration of β-melanocyte-stimulating hormone decreased food intake in layer chicks but not in broiler chicks. The central administration of agouti-related protein increased food intake in layer chicks but not in broiler chicks. We previously reported that glucagon and neuromedin U (NMU) suppress food intake in layer chicks when administered centrally. However, the effects of these peptides on food intake in broiler chicks have not been examined. In the present study, we thus examined whether these peptides also show anorexigenic effects in broiler chicks. The intracerebroventricular administration of glucagon significantly suppressed food intake and increased plasma glucose concentration in broiler chicks. The hyperglycemic effect of glucagon had been shown in layer chicks in our previous studies. Intracerebroventricular administration of NMU significantly suppressed food intake and induced wingflapping behavior in broiler chicks as well as in layer chicks. All our findings demonstrate that glucagon and NMU function as anorxigenic peptides in both broiler and layer chicks.

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Neuropeptide Y effect on food intake in broiler and layer chicks

Cited by 43 publications

References 45 publications

Age-Dependent Changes in the mRNA Levels of Neuropeptide Y, Proopiomelanocortin, and Corticotropin-Releasing Factor in the Hypothalamus in Growing Broiler Chicks

Age-Dependent Changes in the mRNA Levels of Neuropeptide Y, Proopiomelanocortin, and Corticotropin-Releasing Factor in the Hypothalamus in Growing Broiler Chicks

Central regulation of food intake in mammals and birds: a review

Glucagon and Neuromedin U Suppress Food Intake in Broiler Chicks

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