Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress: replication and extension of previous report

Morgan, Charles A.; Rasmusson, Ann M.; Wang, Sheila; Hoyt, Gary; Hauger, Richard L.; Hazlett, Gary

doi:10.1016/s0006-3223(02)01319-7

Cited by 206 publications

(135 citation statements)

References 29 publications

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“…Additionally, data from American soldiers undergoing survival training demonstrated that acute uncontrollable stress significantly increases plasma NPY concentrations. Relatively higher NPY concentrations were associated with increased resilience and less psychological distress (7,8). Conversely, depleted plasma NPY levels correlated with poorer stress-handling ability and higher dissociation scores (7,8).…”

mentioning

confidence: 95%

Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder

Sah

Ekhator

Strawn

et al. 2009

Biological Psychiatry

127

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mentioning

confidence: 95%

Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder

Sah

Ekhator

Strawn

et al. 2009

Biological Psychiatry

127

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“…In another study published by the same lab, the data replicated the previous study and demonstrated that acute stress elicited NPY release. This NPY release was positively associated with cortisol and norepinephrine release (Morgan et al, 2002). The study also showed that greater levels of NPY are associated with less psychological distress (Morgan et al, 2002).…”

Section: Salivary Neuropeptide Y As a Marker For Stressmentioning

confidence: 70%

“…This NPY release was positively associated with cortisol and norepinephrine release (Morgan et al, 2002). The study also showed that greater levels of NPY are associated with less psychological distress (Morgan et al, 2002). Morgan et al (2002) suggests that NPY confers anxiolytic activity which means it is associated with less anxiousness.…”

Section: Salivary Neuropeptide Y As a Marker For Stressmentioning

confidence: 81%

“…The study also showed that greater levels of NPY are associated with less psychological distress (Morgan et al, 2002). Morgan et al (2002) suggests that NPY confers anxiolytic activity which means it is associated with less anxiousness. Cortisol, however, was found to be positively correlated with distress (Morgan et al 2002).…”

Section: Salivary Neuropeptide Y As a Marker For Stressmentioning

confidence: 82%

“…Morgan et al (2002) suggests that NPY confers anxiolytic activity which means it is associated with less anxiousness. Cortisol, however, was found to be positively correlated with distress (Morgan et al 2002). Heilig et al, (2004) also reports that NPY is active in a wide range of anxiety models and that NPY may have anxiolytic like actions (Heilig et al, 2004).…”

Section: Salivary Neuropeptide Y As a Marker For Stressmentioning

confidence: 99%

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Salivary VIP concentrations are elevated in humans after acute stress

et al. 2013

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Emotion Processing, Major Depression, and Functional Genetic Variation of Neuropeptide Y

Mickey¹,

Zhou²,

Heitzeg³

et al. 2011

Arch Gen Psychiatry

101

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Context Despite recent progress in describing the common neural circuitry of emotion and stress processing, the bases of individual variation are less well understood. Genetic variants that underlie psychiatric disease have proved particularly difficult to elucidate. Functional genetic variation of neuropeptide Y (NPY) was recently identified as a source of individual differences in emotion. Low NPY levels have been reported in major depressive disorder (MDD). Objective To determine whether low-expression NPY genotypes are associated with negative emotional processing at three levels of analysis. Design Cross-sectional, case-control. Setting Academic medical center. Participants Forty-four individuals with MDD and 137 healthy controls; 152 (84%) were classified by NPY genotype as low, intermediate, or high, according to previously established haplotype-based expression data. Main Outcome Measures Healthy subjects participated in functional magnetic resonance imaging while viewing negative (versus neutral) words (n=58), and rated positive and negative affect during a pain-stress challenge (n=78). Genotype distribution was compared between 113 control and 39 MDD subjects. Results Among healthy individuals, negatively valenced words activated medial prefrontal cortex. Activation within this region was inversely related to genotype-predicted NPY expression (p=0.029). Whole-brain regression of responses to negative words showed that rostral anterior cingulate cortex activated in the low-expression group and deactivated in the high-expression group (p<0.05). During the stress challenge, individuals with low-expression NPY genotypes reported more negative affective experience before and after pain (p=0.002). Low-expression NPY genotypes were over-represented in MDD after controlling for age and sex (p=0.004). Population stratification did not account for the results. Conclusions These findings support a model in which NPY genetic variation predisposes certain individuals to low NPY expression, thereby increasing neural responsivity to negative stimuli within key affective circuit elements, including medial prefrontal and anterior cingulate cortices. These genetically influenced neural response patterns appear to mediate risk for some forms of MDD.

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Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress: replication and extension of previous report

Cited by 206 publications

References 29 publications

Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder

Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder

Salivary VIP concentrations are elevated in humans after acute stress

Emotion Processing, Major Depression, and Functional Genetic Variation of Neuropeptide Y

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