Neuropeptide Y and sleep

Possible involvement of activated locus coeruleus–noradrenergic neurons in pain-related sleep disorders

“…Although it has been considered that several areas in the brainstem and forebrain are important for modulation and expression of the sleep/wake cycle [8], and several neurotransmitters and neuropeptides are involved in modulation of this cycle [9][10][11], the neurophysiological and molecular mechanisms by which neuropathic pain affects sleep/arousal patterns are not fully understood. The LC is a dense collection of noradrenaline-containing neurons in the dorsolateral pontine tegmentum, and is thought to play a major role in promoting both tonic and phasic processes of arousal [1,12].…”

When time stands still

“…Neuropeptide Y (NPY) has been implicated in the regulation of several physiological functions such as metabolism, memory and cognition, thermoregulation, sleep and stress regulation [135,136]. Central NPY is involved in circadian entrainment by mediating both photic and nonphotic influences on the SCN and moderating phase-shifting and melatonin secretion [137][138][139].…”

Stimulatory effects of neuropeptide Y on the growth of orange-spotted grouper (Epinephelus coioides)

“…In addition to its major roles on food intake and energy balance, in mammals, the NPY system has been reported to be involved in a broad range of physiological functions including hormonal release [3,36], obesity [27], stress response [40], anxiety [17] and sleep [19]. In fish, NPY is also involved in a variety of regulatory functions such as vasorelaxation [50], innate immunity [7], stress regulation [18] and pituitary hormone secretion [5,13,23].…”