Neuropeptide Y

Benarroch, Eduardo E.

doi:10.1212/01.wnl.0000345258.18071.54

Cited by 56 publications

(49 citation statements)

References 30 publications

(48 reference statements)

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“…Figure used with permission from Vázquez-Acevedo et al (2009) Circulating hormones modulate feeding-related behavior in most animals. In vertebrates, one group of peptides that plays a key role in the control of food intake, among other functions, is the neuropeptide Y (NPY) superfamily (e.g., Pedrazzini et al 2003;Emeson and Morabito 2005;Karl and Herzog 2007;Chee and Colmers 2008;Thorsell 2008;Benarroch 2009). Whereas no authentic NPY has yet been identified in any invertebrate, a broadly conserved subgroup of the FLP superfamily, commonly referred to as the NPFs, has been proposed as their homolog (Walker et al 2010).…”

Section: Modulation Of Food Intake and Growth By Npfmentioning

confidence: 99%

Crustacean neuroendocrine systems and their signaling agents

Christie

2011

Cell Tissue Res

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Decapod crustaceans have long served as important models for the study of neuroendocrine signaling. For example, the process of neurosecretion was first formally demonstrated by using a member of this order. In this review, the major decapod neuroendocrine organs are described, as are their phylogenetic conservation and neurochemistry. In addition, recent advances in crustacean neurohormone discovery and tissue mapping are discussed, as are several recent advances in our understanding of hormonal control in this group of animals.

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Section: Modulation Of Food Intake and Growth By Npfmentioning

confidence: 99%

Crustacean neuroendocrine systems and their signaling agents

Christie

2011

Cell Tissue Res

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“…Several physiological functions have been attributed to NPY, including involvement in the anxiety response [4,5], sexual function, peripheral vascular resistance [6,7,8] and circadian rhythms [9,10]. NPY has also been reported to have a potent effect on appetite [11].…”

Section: Introductionmentioning

confidence: 99%

Lack of an Association between a Functional Polymorphism in the Neuropeptide Y Gene Promoter and the Presence of Coronary Artery Disease in an Iranian Population

Parizadeh

Jamialahmadi²,

Rooki³

et al. 2014

Ann Nutr Metab

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Background/Aims: Several genetic factors have been identified that may contribute to the risk of coronary artery disease (CAD). Variants of the neuropeptide Y (NPY) gene, whose products play an important role in regulating several physiological functions, have been associated with the risk of CAD in some populations. The purpose of this study was to investigate the relationship between the NPY gene rs16147 polymorphism and the presence of CAD in an Iranian population. Methods: DNA samples of 922 subjects, including 433 with angiographically defined CAD (CAD+), 196 without angiographically defined significant CAD (CAD-) and 293 controls, were genotyped using polymerase chain reaction based on the amplification-refractory mutation system. Logistic regression analyses were performed to assess the association of rs16147 genotypes with the presence of significant CAD. Results: Although logistic regression analysis indicated that the NPY polymorphism rs16147 was nominally associated with an increased risk of CAD (p < 0.05), after adjustment for confounding factors, there was no evidence for any signiﬁcantly increased or decreased risk of CAD with this polymorphism. However, in stratiﬁed analyses, the C allele was signiﬁcantly associated with a reduced risk of CAD in males and subjects who were <50 years of age. Conclusions: This study suggests that the rs16147 polymorphism in the NPY gene may not be a potential contributor to the risk of CAD in an Iranian population.

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“…Neuropeptide Y (NPY), a 36-amino-acid peptide, is expressed at high levels within the nervous system [16,17]. The NPY gene (NP-Y) is a potential candidate gene involved in nicotine dependence because NP-Y has been shown to increase extracellular dopamine levels dose-dependently in the shell region of the nucleus accumbens in rats [18].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variation in the Neuropeptide Y Gene Promoter Is Associated with Increased Risk of Tobacco Smoking

et al. 2012

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Background: Neuropeptide Y (NPY) is a strong candidate gene regarding the pathophysiology of tobacco dependence. It has been associated with various addictive and psychiatric disorders, and closely interacts with the brain reward system. The aim of the present study was to test for association between a functional genetic variant in the NP-Y promoter gene (SNP rs16147) and tobacco smoking. Methods: In a population-based case-control multicenter study designed for tobacco addiction research, a total of 550 Caucasian current smokers, and 544 never-smokers were genotyped for SNP rs16147 and behaviorally characterized with the State-Trait Anxiety Inventory (STAI). Results: Subjects with TT genotype of the SNP rs16147 were significantly more frequently smokers than never-smokers (p = 0.046). In addition, TT genotype exhibited increased state anxiety scores compared to carriers of the C allele (p = 0.037). Conclusions: Our results provide evidence for an involvement of the functionally relevant SNP rs16147 in the pathophysiology of tobacco dependence. Further studies are needed to confirm our findings.

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Neuropeptide Y

Cited by 56 publications

References 30 publications

Crustacean neuroendocrine systems and their signaling agents

Crustacean neuroendocrine systems and their signaling agents

Lack of an Association between a Functional Polymorphism in the Neuropeptide Y Gene Promoter and the Presence of Coronary Artery Disease in an Iranian Population

Genetic Variation in the Neuropeptide Y Gene Promoter Is Associated with Increased Risk of Tobacco Smoking

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