Lack of an Association between a Functional Polymorphism in the Neuropeptide Y Gene Promoter and the Presence of Coronary Artery Disease in an Iranian Population

Abstract

Background/Aims: Several genetic factors have been identified that may contribute to the risk of coronary artery disease (CAD). Variants of the neuropeptide Y (NPY) gene, whose products play an important role in regulating several physiological functions, have been associated with the risk of CAD in some populations. The purpose of this study was to investigate the relationship between the NPY gene rs16147 polymorphism and the presence of CAD in an Iranian population. Methods: DNA samples of 922 subjects, including 433 with angiographically defined CAD (CAD+), 196 without angiographically defined significant CAD (CAD-) and 293 controls, were genotyped using polymerase chain reaction based on the amplification-refractory mutation system. Logistic regression analyses were performed to assess the association of rs16147 genotypes with the presence of significant CAD. Results: Although logistic regression analysis indicated that the NPY polymorphism rs16147 was nominally associated with an increased risk of CAD (p < 0.05), after adjustment for confounding factors, there was no evidence for any significantly increased or decreased risk of CAD with this polymorphism. However, in stratified analyses, the C allele was significantly associated with a reduced risk of CAD in males and subjects who were <50 years of age. Conclusions: This study suggests that the rs16147 polymorphism in the NPY gene may not be a potential contributor to the risk of CAD in an Iranian population.

Allele a of the rs16147 variant of neuropeptide Y predicts early metabolic improvements after bariatric surgery with biliopancreatic diversion in morbid obese subjects

“…One of the most important variant within the promoter region upstream of the NPY is rs16147 (G-399 A) [6] and this genetic variant a substitution G to A (G as major allele and A as minor allele). This genetic variant has been related with serum levels of NPY [7], and it is related with more than half of the variation in the expression of this peptide [8] and this genetic variants of NPY gene could produce metabolic disorders associated with obesity [9,10].…”

Polymorphism <b><i>rs16147</i></b> of the <b><i>Neuropeptide Y</i></b> Gene Modifies the Response of Cardiovascular Risk Biomarkers and Adipokines to Two Hypocaloric Diets

“…In addition, the above-mentioned SNP has been shown to be related with serum levels of NPY [5] and to be responsible for more than half of the variation in the expression of NPY [6]. Few previous studies have shown an association between SNPs of NPY and early onset of atherosclerosis, stroke, and hypertension [7,8]. Moreover, adipose tissue is recognized as an endocrine organ producing several proteins, called adipokines, produced by adipose tissue (leptin, adiponectin, resistin, etc.).…”