Neuropeptide Receptors as Possible Targets for Development of Insect Pest Control Agents

Hiel, Matthias B. Van; Loy, Tom Van; Poels, Jeroen; Vandersmissen, Hans Peter; Verlinden, Heleen; Badisco, Liesbeth; Broeck, Jozef Vanden

doi:10.1007/978-1-4419-6902-6_11

Cited by 42 publications

(24 citation statements)

References 129 publications

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“…Neuropeptides and their cognate receptors, which have a central role in the regulation of physiological and behavioral processes in insects, are considered important targets for the development of novel pesticides [25,49]. A variety of insect neuropeptides and neuropeptide analogues have been shown to be insecticidal.…”

Section: Introductionmentioning

confidence: 99%

Genomic and peptidomic analyses of the neuropeptides from the emerging pest, Drosophila suzukii

2015

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Tel: +44 (0)1904 4626282 Highlights  In silico analysis identified 28 peptide precursors  Peptidome analysis of adult brain, corpus cardiacum, thoracico-abdominal ganglion identified peptides from 15 different families.  Myosuppressin was present in all tissue analysed, and was the only peptide identified in the crop nerve bundle AbstractDrosophila suzukii is a highly polyphagous invasive pest which has been recently introduced into Europe and North America, where it is causing severe economic losses through larval infestations of stone and berry fruits. The peptidome of the selected nervous tissues of adult D. suzukii was investigated as a first step in identifying potential targets for the development of novel insecticides.Through in silico analyses of the D. suzukii genome databases 28 neuropeptide families, comprising more than 72 predicted peptides were identified. Using a combination of liquid chromatography and mass spectrometry of tissue extracts, 33 predicted peptides, representing 13 different peptide families were identified by their molecular masses and a total of 17 peptide sequences were confirmed by ion fragmentation.A comparison between the peptides and precursors of D. suzukii and D. melanogaster shows they are highly conserved, with differences only identified in the amino acid sequences of the peptides encoded in the FMRFamide, hugin and ecydysis triggering hormone precursors. All other peptides predicted and identified from D. suzukii appear to be identical to those previously characterized from D. melanogaster.Adipokinetic hormone was only identified in the corpus cardiacum, other peptides present included short neuropeptide F, a pyrokinin and myosuppressin, the latter of which was the only peptide identified from the crop nerve bundle. Peptides present in extracts of the brain and/or thoracicoabdominal ganglion included allatostatins, cardioacceleratory peptide 2b, corazonin, extended FMRFamides, pyrokinins, myoinihibitory peptides, neuropeptide-like precursor 1, SIFamide, short neuropeptide F, kinin, sulfakinins and tachykinin related peptides.

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Section: Introductionmentioning

confidence: 99%

Genomic and peptidomic analyses of the neuropeptides from the emerging pest, Drosophila suzukii

2015

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“…4 by Bai and Palli 2012 , this book) but, paradoxically, this class of receptors has received relatively little attention as targets for insecticide action (Van Hiel et al 2010 ) . In many cases, activation of GPCRs results in the production of intracellular messengers such as cAMP and calcium for which fl uorescent and luminescent detection methods are readily available for screening in high-throughput format (Milligan 2003 ;Williams 2004 ) .…”

Section: G Protein-coupled Receptors (Gpcrs)mentioning

confidence: 98%

“…Many GPCRs are involved in important physiological and developmental processes in insects and thus represent excellent targets (Van Hiel et al 2010 ) . Recently, a large scale RNAi-based screen was carried out in Tribolium to identify GPCRs involved in growth, molting and metamorphosis (Bai et al 2011 ) .…”

Section: G Protein-coupled Receptors (Gpcrs)mentioning

confidence: 99%

Cell-Based Screening Systems for Insecticides

Smagghe

Swevers

2012

Advanced Technologies for Managing Insect Pests

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“…Once the precise EC/IC 50 of Phote-HrTH are known, one can use this as the starting point, along with information on the Phote-HrTH receptor (see Staubli et al, 2002), in establishing and testing a potential biorational pesticide control strategy. Such strategies for modifying peptides as biorational control agents have been proposed by Altstein et al (2000) and Van Hiel et al (2010).…”

Section: Targeting Phote-hrth As a Biorational Pesticidementioning

confidence: 99%

Role of Phote-HrTH (Phormia terraenovae hypertrehalosemic hormone) in modulating the supercontractile muscles of the crop of adult Phormia regina Meigen

Stoffolano

Croke

Chambers

et al. 2014

Journal of Insect Physiology

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Neuropeptide Receptors as Possible Targets for Development of Insect Pest Control Agents

Cited by 42 publications

References 129 publications

Genomic and peptidomic analyses of the neuropeptides from the emerging pest, Drosophila suzukii

Genomic and peptidomic analyses of the neuropeptides from the emerging pest, Drosophila suzukii

Cell-Based Screening Systems for Insecticides

Role of Phote-HrTH (Phormia terraenovae hypertrehalosemic hormone) in modulating the supercontractile muscles of the crop of adult Phormia regina Meigen

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