Neuropeptide FF exerts pro- and anti-opioid actions in the parabrachial nucleus to modulate food intake

Nicklous, Danielle M.; Simansky, Kenny J.

doi:10.1152/ajpregu.00107.2003

Cited by 53 publications

(45 citation statements)

References 67 publications

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“…Rats drank at the spout relatively few times after DAMGO in the present study. In a recent experiment (66), rats did consume more water after parabrachial administration of DAMGO during a 2-h test with food present, but not when food was absent. Thus any increase in water intake after parabrachial DAMGO is prandial and secondary to the hyperphagic action of this -agonist.…”

Section: Discussionmentioning

confidence: 88%

An orexigenic role for μ-opioid receptors in the lateral parabrachial nucleus

Wilson

Nicklous

Aloyo

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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. The pontine parabrachial nucleus (PBN) has been implicated in regulating ingestion and contains opioids that promote feeding elsewhere in the brain. We tested the actions of the selective -opioid receptor (-OR) agonist [D-Ala 2 ,N-Me-Phe 4 ,Gly 5 -ol]enkephalin (DAMGO) in the PBN on feeding in male rats with free access to food. Infusing DAMGO (0.5-4.0 nmol/0.5 l) into the lateral parabrachial region (LPBN) increased food intake. The hyperphagic effect was anatomically specific to infusions within the LPBN, dose and time related, and selective for ingestion of chow compared with (nonnutritive) kaolin. The nonselective opioid antagonist naloxone (0.1-10.0 nmol intra-PBN) antagonized DAMGO-induced feeding, with complete blockade by 1.0 nmol and no effect on baseline. The highly selective -opioid antagonist D-Phe-Cys-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP; 1.0 nmol) also prevented this action of DAMGO, but the -antagonist nor-binaltorphimine did not. Naloxone and CTAP (10.0 nmol) decreased intake during scheduled feeding. Thus stimulating -ORs in the LPBN increases feeding, whereas antagonizing these sites inhibits feeding. Together, our results implicate -ORs in the LPBN in the normal regulation of food intake.feeding; hyperphagia; DAMGO; naloxone; CTAP STIMULATING ANY OF THE SUBTYPES of opioid receptors (ORs; , , ␦) or the related orphan receptor for nociceptin increases food intake in mammals (6,24,26,71,77). The orexigenic effects of these treatments are evident particularly in settings using preferred foods for the test diet (e.g., 39, 94, 95), although consumption of standard chow is also enhanced (9, 72). Conversely, drugs that block ORs reduce food intake (11,16,41,49). This hypophagia may occur especially under conditions when opioid pathways are highly activated (53). The data, therefore, suggest that opioid peptides play roles in the physiological control of feeding.The anatomic loci subserving opioidergic feeding are distributed widely throughout the brain. Attention has focused on the nucleus accumbens (NAC) and the rest of the ventral striatum as a critical region (9,72,94,95). Infusing opioid agonists into the ventral tegmental area of the midbrain, which projects onto the ventral striatum, also stimulates feeding (45, 67); this circuitry is consistent with the view assigning a broader role for opioids to support positive affect and appetitive reward (39, 70). Another (probably integrated) circuit is defined by observations that opioid stimulation of the paraventricular hypothalamic nucleus (21, 22) The parabrachial nucleus (PBN) of the pons has bidirectional communication with the PVN, central nucleus of the amygdala, and NTS (19,29,61,62). The multiple subnuclei of the PBN sort afferent input from second-order sensory neurons originating in the NTS and spinal cord (38,83) and distribute the information to rostral targets (19,36,37,68). This sensory processing includes neurotransmission underlying gustatory and visceral function and their convergence (8,30,38).It is logical, then, that the PBN has been imp...

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Section: Discussionmentioning

confidence: 88%

An orexigenic role for μ-opioid receptors in the lateral parabrachial nucleus

Wilson

Nicklous

Aloyo

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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“…The presence of somatostatin and of the neuropeptide FF receptor FF1 let to speculations that it might be involved in the regulation of food intake and in the homeostasis of the neuroendocrine system (Timmers et al, 1996;Goncharuk et al, 2004;Dockray, 2004;Nicklous and Simansky, 2003).…”

Section: Discussionmentioning

confidence: 99%

The human lateral tuberal nucleus: Immunohistochemical characterization and analogy to the rodent PV1-nucleus

Gerig

Celio

2007

Brain Research

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A B S T R A C TThe lateral tuberal nucleus (LTN) is a hypothalamic region that has been identified with certainty only in humans and primates. It is composed of three small round globular units which protrude the basal surface of the brain along the optic tract. The function of the LTN is unknown. Recently, a tiny, parvalbumin-positive (PV1) nucleus was detected in the lateral hypothalamus of rodents. Like the human LTN, the rodent PV1-nucleus is subdivided into three units and lies along the optic tract. To ascertain whether the human LTN and the rodent PV1-nucleus could be considered as homologous structures not only based on their topographic location but also because of their neurochemical characteristics, we subjected tissue samples from humans, rats and mice to immunohistochemical analysis for a panel of neural markers. The human LTN was intensely immunoreactive for somatostatin and FF1, but only weakly so or not at all for parvalbumin, calbindin and calretinin. The rodent PV1-nucleus was intensely immunoreactive for parvalbumin but was not immunoreactive for either somatostatin, a surrogate for human FF1, calbindin or calretinin. Hence, using these neural markers, it was not possible to demonstrate a neurochemical homology between the human LTN and the rodent PV1-nucleus.

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“…NPFF immunoreactive fibres densely innervate another area implicated in feeding behaviour, the PBN. Administration of NPFF into the PBN in relatively low doses (!10 nmol) can inhibit the stimulation of food intake in response to the m-opioid receptor agonist, [D-Ala, N-MePhe, Gly-oL]-enkephalin (DAMGO; Nicklous & Simansky 2003). Interestingly, higher doses of NPFF caused an increase in food intake which could be blocked by naloxone, an opioid receptor antagonist.…”

Section: Npff Familymentioning

confidence: 99%

The role of RFamide peptides in feeding

Bechtold

Luckman

2007

Journal of Endocrinology

116

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In the three decades since FMRFamide was isolated from the clam Macrocallista nimbosa, the list of RFamide peptides has been steadily growing. These peptides occur widely across the animal kingdom, including five groups of RFamide peptides identified in mammals. Although there is tremendous diversity in structure and biological activity in the RFamides, the involvement of these peptides in the regulation of energy balance and feeding behaviour appears consistently through evolution. Even so, questions remain as to whether feedingrelated actions represent a primary function of the RFamides, especially within mammals. However, as we will discuss here, the study of RFamide function is rapidly expanding and with it so is our understanding of how these peptides can influence food intake directly as well as related aspects of feeding behaviour and energy expenditure.

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Neuropeptide FF exerts pro- and anti-opioid actions in the parabrachial nucleus to modulate food intake

Cited by 53 publications

References 67 publications

An orexigenic role for μ-opioid receptors in the lateral parabrachial nucleus

An orexigenic role for μ-opioid receptors in the lateral parabrachial nucleus

The human lateral tuberal nucleus: Immunohistochemical characterization and analogy to the rodent PV1-nucleus

The role of RFamide peptides in feeding

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