Neuropathy of Uremia: Evaluation by Nerve Conduction Velocity versus Neurospecific Current Perception Threshold

Abstract

Normal peripheral nerve conduction is a marker of adequate dialytic therapy in the ESRD population. Decreasing nerve function detected by periodic testing indicates insufficient dialysis. The standard test for the quantitative evaluation of nerve integrity is the nerve conduction test (NCT). A study of 34 dialysis patients proves that the measurement of current perception threshold (CPT) is equally effective to NCT in defining peripheral nerve function (r = 0.81; p < 0.001). The superiority of the CPT examination is discussed.

Evoked potentials in children with chronic renal failure, treated conservatively or by continuous ambulatory peritoneal dialysis

“…In adults with end-stage renal disease polyneuropathy, demonstrated by the delay of peripheral conduction velocity, is frequently present [19][20][21][22]. The central conduction is also decreased, as measured by BAEP [23][24][25] and SSEP [22,24].…”

Pudendal and median nerve sensory perception threshold: A comparison between normative studies

“…In the literature, ratios of sensory threshold values (Katims et al , 1991Weseley et al 1989) or various degrees of deviation from a normal population are categorized as severity grades (Katims et al , 1991Weseley et al 1989;Pitei et al 1994).…”

Aging and overactive bladder may be associated with loss of urethral sensation in women

“…CPTs have shown good agreement with and nerve conduction studies in a variety of peripheral neuropathies. [12][13][14] In addition, CPT testing has detected abnormalities in A-d and C fibers in a variety of disease states: diabetic and alcoholic neuropathies, 15 and arsenic poisoning. 16 Likewise, chronic lead exposure is associated with elevated CPT at 2,000 Hz 17 and elevated vibration perception thresholds, 18 both believed to measure A-b fibers; and, these findings agree with biopsy results which showed loss of large, myelinated fibers in the sensory nerve of a patient with lead neuropathy.…”