Neuropathological Findings in 9 Cases of Listeria Monocytogenes Brain Stem Encephalitis

Antal, Ellen‐Ann; Løberg, E. M.; Dietrichs, Espen; Mæhlen, Jan

doi:10.1111/j.1750-3639.2005.tb00519.x

Cited by 50 publications

(79 citation statements)

References 20 publications

(23 reference statements)

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“…On the other hand, listerial rhombencephalitis may be explained by axonal transport of food borne Listeria to the brainstem, after entering cranial nerve endings [1]. The proposition of two different mechanisms for two different lesions (supratentorial abscesses and rhombencephalitis) strengthens the presumed blood dissemination through the perforating arteries of the basal ganglia and brainstem in our patient.…”

Section: Discussionmentioning

confidence: 64%

Simultaneous supratentorial and brainstem abscesses due to Listeria monocytogenes

Soares-Fernandes

Beleza

Cerqueira

et al. 2008

Journal of Neuroradiology

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Multiple supratentorial abscesses caused by Listeria monocytogenes are rare. We report the simultaneous occurrence of multiple supratentorial and brainstem abscesses due to Listeria, in a patient under corticotherapy for an exacerbation of ulcerative colitis. MR imaging features before and after successful conservative treatments are depicted. In immunocompromised patients with supratentorial listerial abscesses, the coexistence of brainstem abscedation is exceptional. Despite high mortality associated with listerial abscesses, this case illustrates the possibility of a good clinical outcome, if the appropriate antibiotic regimen is instituted and the immunosuppressant agent is discontinued. © 2007 Elsevier Masson SAS. All rights reserved. MOTS CLÉS

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Section: Discussionmentioning

confidence: 64%

Simultaneous supratentorial and brainstem abscesses due to Listeria monocytogenes

Soares-Fernandes

Beleza

Cerqueira

et al. 2008

Journal of Neuroradiology

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“…Si no se trata rápidamente es fatal, pero aun con tratamiento deja secuelas neurológicas en el 62 % de los casos (11,12). La encefalitis del tallo cerebral ocurre en, al menos, 10 % de los casos de listeriosis en humanos (13).…”

Section: Discussionunclassified

“…El compromiso de neuronas motoras y sensitivas, indica que la bacteria se disemina anterógrada y retrógradamente por migración axonal (10). Nuestro caso favorece esta teoría; suponemos que luego del consumo de leche no pasteurizada, L. monocytogenes probablemente infectó la mucosa En un estudio descriptivo en Noruega, de 19 casos de encefalitis del tallo cerebral, se encontró que los infiltrados inflamatorios estaban predominantemente en los núcleos, tractos y regiones intraparenquimatosas de los nervios craneales que inervan la orofaringe (V, VII, IX, X y XII) (13).…”

Section: Discussionunclassified

Encefalitis del tallo cerebral y mielitis por Listeria monocytogenes: caso clínico y revisión del tema

et al. 2013

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La romboencefalitis por Listeria monocytogenes es una presentación poco común de la listeriosis del sistema nervioso central; sin embargo, es la presentación más común en personas inmunocompetentes. Aun más rara es la combinación de romboencefalitis con mielitis causada por L. monocytogenes; no obstante, en este artículo se reporta un caso de encefalitis del tallo y mielitis grave en un paciente sin compromiso del sistema inmunitario. Se presenta un paciente de 21 años de edad, sin deficiencias del sistema inmunitario, que consumió productos lácteos no pasteurizados y, posteriormente, presentó un cuadro de cefalea, vómito, deterioro de su estado general y, finalmente, alteración del estado de conciencia y muerte. Consultó al Instituto Neurológico de Colombia y se hizo diagnóstico de encefalitis del tallo y mielitis por L. monocytogenes. Se discuten las diferencias entre el caso presentado y los reportados en la literatura científica. Ante un paciente con signos de compromiso del tallo cerebral, de posible origen infeccioso, es prudente iniciar tratamiento antibiótico para L. monocytogenes y, en caso de poca respuesta, escalar rápidamente en dicho tratamiento. También lo es extender el estudio radiológico hacia la columna vertebral, con el fin de descartar compromiso de la médula espinal. Brainstem encephalitis and myelitis due to Listeria monocytogenes: a case report and literature reviewBrainstem encephalitis caused by Listeria monocytogenes is an uncommon form of central nervous system listeriosis; however, it is the most common presentation in immunocompetent individuals. Here, we describe an even more rare combination of rhombencephalitis with severe myelitis caused by L. monocytogenes in an immunocompetent patient. We report the case of a 21-year-old immunocompetent patient who consumed unpasteurized dairy products and experienced headache and vomiting that progressed to an impaired general condition, altered consciousness and ultimately death. The patient had presented to the Neurological Institute of Colombia (INDEC in Spanish) for consultation and was diagnosed with brainstem encephalitis and myelitis caused by Listeria monocytogenes. The differences between this particular case and those reported in the literature will be discussed. It is advisable to initiate antibiotic treatment for Listeria monocytogenes if a patient shows signs of brainstem compromise of possible infectious origin and quickly intensify treatment if there is no or minimal response. It is also necessary to extend radiological assessment to include the spinal column to rule out spinal cord involvement. Keywords Contribución de los autores:Aracelly Castro, Olga Hernández y Carlos Santiago hicieron la revisión del tema y la escritura del artículo. Alejandro Guerra facilitó el caso del paciente. Piedad Urueña facilitó la revisión de las imágenes y su interpretación específica para este artículo.Listeria monocytogenes es un bacilo Gram positivo que infecta al ser humano principalmente por el consumo de alimentos contaminados y que ha mos...

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“…[2] A postmortem study of nine human cases of LBE revealed brainstem microabscesses that were prominently distributed within the nuclei, tracts and intraparenchymal portions of the cranial nerves innervating the oropharynx (V, VII, IX, X and XII). [9] Injection of listerial bacteria into the facial nerves of mice was followed 5 10 days later by ipsilateral CNS deficits that were prevented by section of the nerve proximal to the inoculation site. [10] Similarly, injection of listerial bacteria into the sciatic nerves of mice resulted in a flaccid paraparesis that was prevented by sectioning the sciatic nerve proximal to the inoculation site.…”

Section: Discussionmentioning

confidence: 99%

Listerial brainstem encephalitis – treatable, but easily missed

et al. 2014

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Neuropathological Findings in 9 Cases of Listeria Monocytogenes Brain Stem Encephalitis

Cited by 50 publications

References 20 publications

Simultaneous supratentorial and brainstem abscesses due to Listeria monocytogenes

Simultaneous supratentorial and brainstem abscesses due to Listeria monocytogenes

Encefalitis del tallo cerebral y mielitis por Listeria monocytogenes: caso clínico y revisión del tema

Listerial brainstem encephalitis – treatable, but easily missed

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