1992
DOI: 10.1016/0022-510x(92)90047-o
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Neuropathological background of twenty-seven centenarian brains

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Cited by 97 publications
(42 citation statements)
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“…In contrast to NFT, the frequent presence of diffuse Aß deposits and SP in area 17 in ND and VMCI centenarians reported here is consistent with previous studies showing an early and widespread amyloid pathology within the cerebral cortex in this age group [32,39,41,[51][52][53]. However, in agreement with a previous study of the entorhinal cortex [54], our results demonstrate that only 1-2.4% of the cross-sectional area of the primary visual cortex is covered by Aß in ND, VMCI and AD centenarians, implying that only a weak proportion of the whole functional tissue of the primary visual cortex is affected by amyloid deposition in this age group.…”
Section: Discussionsupporting
confidence: 81%
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“…In contrast to NFT, the frequent presence of diffuse Aß deposits and SP in area 17 in ND and VMCI centenarians reported here is consistent with previous studies showing an early and widespread amyloid pathology within the cerebral cortex in this age group [32,39,41,[51][52][53]. However, in agreement with a previous study of the entorhinal cortex [54], our results demonstrate that only 1-2.4% of the cross-sectional area of the primary visual cortex is covered by Aß in ND, VMCI and AD centenarians, implying that only a weak proportion of the whole functional tissue of the primary visual cortex is affected by amyloid deposition in this age group.…”
Section: Discussionsupporting
confidence: 81%
“…Importantly, it has recently been shown that brains from ND old people can remain free of amyloid pathology until the 8th decade [55], and it is interesting to note that in the present series, 6 brains are totally devoid of SP and diffuse Aß deposits in the visual cortex. This was also shown in other brain regions for a minority of centenarians referred to as 'supernormal' [39,41]. Moreover, unlike younger elderly individuals, the LGN, the first thalamic visual relay, is consistently spared by Aß pathology in the very old, even in AD cases [25].…”
Section: Discussionmentioning
confidence: 62%
“…A recent report by Mizutani and Hiroyuki [21] of 27 centenarians is of interest; they found no difference be tween brains of centenarians and those of younger elderly; three brains lacked Alzheimer-type changes or ischemic lesions. There was no significant neuronal loss or neurofi brillary change in the cerebral cortex, hippocampus, or subcortical nuclei in any of the brains.…”
Section: Discussionmentioning
confidence: 99%
“…The axons of the perforant path arise principally in layers II and III of the entorhinal cortex, with minor contributions from the deeper layers IV and V. Axons from layers II/IV project to the granule cells of the dentate gyrus and pyramidal cells of the CA3 region, whereas those from layers III/V project to the pyramidal cells of the CA1 and the subiculum. Pathologic findings [37][38][39][40] in patients with AD suggested that severe degeneration of the perforant pathway was a characteristic feature of AD. Our results showing the significant changes in the hippocampal surface were a probable consequence of this phenomenon.…”
Section: Pathologic Implications Of the Selected Featuresmentioning
confidence: 99%