Neuropathies and vitamin D deficiency

Luo, Jin Jun; Dun, Nae J.

doi:10.1002/mus.27069

Cited by 3 publications

(5 citation statements)

References 9 publications

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“…6 21 However, it has been reported that large and small fiber neuropathy develops in patients with Type 2 diabetes mellitus and hypovitaminosis D. 21 22 Vitamin D regulates axonal regeneration and remyelination by modulating neurotrophins. 5 6 22 Therefore, it is important to detect hypovitaminosis D in neuropathy cases. Although hypovitaminosis D is not the sole cause of neuropathy in healthy cases, it may be a facilitating factor in the presence of comorbid chronic diseases such as CF.…”

Section: Discussionmentioning

confidence: 99%

“…However, small-fiber changes cannot be displayed in the NCS. 6,21 However, it has been reported that large and small fiber neuropathy develops in patients with Type 2 diabetes mellitus and hypovitaminosis D. 21,22 Vitamin D regulates axonal regeneration and remyelination by modulating neurotrophins. 5,6,22 Therefore, it is important to detect hypovitaminosis D in neuropathy cases.…”

Section: Discussionmentioning

confidence: 99%

“…3 Vitamin D is a neurosteroid and has an important role in the survival and regeneration of neuronal cells. 5,6 Vitamin D regulates nerve growth factors which help in axon regeneration and remyelination. 6 Deficiencies of various micronutrients and vitamins lead to the development of many neurological complications including neuropathy, myopathy, and ophthalmoplegia.…”

Section: Introductionmentioning

confidence: 99%

“…5,6 Vitamin D regulates nerve growth factors which help in axon regeneration and remyelination. 6 Deficiencies of various micronutrients and vitamins lead to the development of many neurological complications including neuropathy, myopathy, and ophthalmoplegia. 7 Improvement in symptoms with oral vitamin D supplementation has been reported in patients with type 2 diabetes mellitus-related neuropathy.…”

Section: Introductionmentioning

confidence: 99%

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Importance of Vitamin D Status and Nerve Conduction in Pediatric Cystic Fibrosis Patients

Polat

Köse

Ayanoğlu

et al. 2023

Journal of Pediatric Neurology

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Cystic fibrosis is one of the most common inherited diseases. It presents with recurrent respiratory infections, pancreatic insufficiency, and growth retardation. Neurological involvement becomes more common as life expectancy increases. Chronic hypoxia, impaired glucose intolerance, autoimmune mechanisms, vasculitis changes, and micronutrient deficiencies seem to cause neuropathy in cystic fibrosis. This study was aimed to investigate peripheral neuropathy in pediatric cystic fibrosis patients. Twenty-one cystic fibrosis patients and 19 healthy control subjects between the ages of 7 and 17 years were included. Their nerve conduction study results and laboratory investigations were analyzed. Participants were classified into four groups; 1. Cystic fibrosis with vitamin D deficiency, 2. Cystic fibrosis with normal vitamin D levels, 3. Healthy subjects with vitamin D deficiency, 4. Healthy subjects with normal vitamin D levels. We found statistically significantly lower sensory median nerve sensorial nerve action potential, sensorial sural nerve conduction velocity, and motor peroneal nerve compound motor action potential in cystic fibrosis patients with vitamin D deficiency than in other cases. We also found that the main difference between cystic fibrosis and control groups was especially in patients with low vitamin D levels. Nerve damage starts at an early age, especially in cystic fibrosis patients especially those with vitamin D deficiency. Electrophysiological evaluation to assess neuropathy is important even in asymptomatic patients. Prevention of hypovitaminosis D is important to prevent neuropathy in cystic fibrosis patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Importance of Vitamin D Status and Nerve Conduction in Pediatric Cystic Fibrosis Patients

Polat

Köse

Ayanoğlu

et al. 2023

Journal of Pediatric Neurology

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“…So, these conditions can have a significant impact on the quality of life of patients. PNs causes can be different, like inherited and hereditary aspects, traumatic injuries, infections, metabolic problems, nutritional deficiencies, or toxic exposure, but also drugs or specific diseases can induce them (2)(3)(4)(5)(6)(7)(8). Sensorimotor polyneuropathies are often experienced by cancer patients (9), and these can be related to their oncologic condition, due to tumor invasion or compression exercised on nerves, or can be associated with a paraneoplastic effect (10).…”

Section: Introductionmentioning

confidence: 99%

Do peripheral neuropathies differ among immune checkpoint inhibitors? Reports from the European post-marketing surveillance database in the past 10 years

et al. 2023

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Although the immunotherapy advent has revolutionized cancer treatment, it, unfortunately, does not spare cancer patients from possible immune-related adverse events (irAEs), which can also involve the peripheral nervous system. Immune checkpoint inhibitors (ICIs), blocking cytotoxic T-lymphocyteassociated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1), or programmed cell death ligand 1 (PD-L1), can induce an immune imbalance and cause different peripheral neuropathies (PNs). Considering the wide range of PNs and their high impact on the safety and quality of life for cancer patients and the availability of large post-marketing surveillance databases, we chose to analyze the characteristics of ICI-related PNs reported as suspected drug reactions from 2010 to 2020 in the European real-world context. We analyzed data collected in the European pharmacovigilance database, Eudravigilance, and conducted a systematic and disproportionality analysis. In our study, we found 735 reports describing 766 PNs occurred in patients treated with ICIs. These PNs included Guillain-Barré syndrome, Miller-Fisher syndrome, neuritis, and chronic inflammatory demyelinating polyradiculoneuropathy. These ADRs were often serious, resulting in patient disability or hospitalization. Moreover, our disproportionality analysis revealed an increased reporting frequency of PNs with tezolizumab compared to other ICIs. Guillain-Barré syndrome is a notable potential PN related to ICIs, as it is associated with a significant impact on patient safety and has had unfavorable outcomes, including a fatal one. Continued monitoring of the safety profile of ICIs in real-life settings is necessary, especially considering the increased frequency of PNs associated with atezolizumab compared with other ICIs.

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