Neuropathic Orofacial Pain

Christoforou, Janina

doi:10.1016/j.cden.2018.05.005

Cited by 20 publications

(17 citation statements)

References 82 publications

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“…The international headache society reported that anatomical boundaries and associated medical specialty demarcations in the orofacial area contributed to the problem ( ICOP, 2020 ). For example, the symptoms of neuropathic pain in the orofacial area often mimic odontogenic toothache, and it can easily be misdiagnosed and misdirected treatment ( Christoforou et al, 2015 ; Christoforou, 2018 ). The orofacial area consists of many kinds of structures innervated by the trigeminal system, head, sinus, masticatory musculature, temporomandibular joint, jaw, teeth, and gingiva, and the complexity induces many kinds of non-odontogenic toothache ( Schames et al, 2016 ).…”

Section: Diagnosis Of Orofacial Neuropathic Painmentioning

confidence: 99%

Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies

Shinoda

Imamura

Hayashi

et al. 2021

Front. Mol. Neurosci.

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Trigeminal nerve injury is known to cause severe persistent pain in the orofacial region. This pain is difficult to diagnose and treat. Recently, many animal studies have reported that rewiring of the peripheral and central nervous systems, non-neuronal cell activation, and up- and down-regulation of various molecules in non-neuronal cells are involved in the development of this pain following trigeminal nerve injury. However, there are many unknown mechanisms underlying the persistent orofacial pain associated with trigeminal nerve injury. In this review, we address recent animal data regarding the involvement of various molecules in the communication of neuronal and non-neuronal cells and examine the possible involvement of ascending pathways in processing pathological orofacial pain. We also address the clinical observations of persistent orofacial pain associated with trigeminal nerve injury and clinical approaches to their diagnosis and treatment.

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Section: Diagnosis Of Orofacial Neuropathic Painmentioning

confidence: 99%

Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies

Shinoda

Imamura

Hayashi

et al. 2021

Front. Mol. Neurosci.

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“…The neuropathic pain occurs in orofacial regions when the V2 branches of trigeminal ganglion nerves (V2 TG) are involved. Trigeminal neuropathic pain is clinically treated with medications such as anticonvulsants, surgery interventions, and alternative medicine (Christoforou, 2018;Devine et al, 2018), but these treatments were not effective for many of the patients (Christoforou, 2018). Mechanisms underlying trigeminal neuropathic pain are not well understood.…”

Section: Introductionmentioning

confidence: 99%

“…The potential roles of these IA channels in trigeminal neuropathic pain have not been well studied. Trigeminal neuropathic pain in human patients are often caused by trigeminal nerve injury following chronic compressions of trigeminal nerves by arteries, tumors, and other pathologic factors (Feller et al, 2017;Christoforou, 2018;Devine et al, 2018;Bendtsen et al, 2019). Therefore, in this study, we used infraorbital nerve chronic constrictive injury (ION-CCI) rat model to study roles of IA cannels in trigeminal neuropathic pain.…”

Section: Introductionmentioning

confidence: 99%

Kv4.3 Channel Dysfunction Contributes to Trigeminal Neuropathic Pain Manifested with Orofacial Cold Hypersensitivity in Rats

et al. 2021

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Trigeminal neuropathic pain is the most debilitating pain disorder but current treatments including opiates are not effective. A common symptom of trigeminal neuropathic pain is cold allodynia/hyperalgesia or cold hypersensitivity in orofacial area, a region where exposure to cooling temperatures are inevitable in daily life. Mechanisms underlying trigeminal neuropathic pain manifested with cold hypersensitivity are not fully understood. In this study, we investigated trigeminal neuropathic pain in male rats following infraorbital nerve chronic constrictive injury (ION-CCI). Assessed by the orofacial operant behavioral test, ION-CCI animals displayed orofacial cold hypersensitivity. The cold hypersensitivity was associated with the hyperexcitability of small-sized trigeminal ganglion (TG) neurons that innervated orofacial regions. Furthermore, ION-CCI resulted in a reduction of A-type voltage-gated K 1 currents (IA currents) in these TG neurons. We further showed that these smallsized TG neurons expressed Kv4.3 voltage-gated K 1 channels, and Kv4.3 expression in these cells was significantly downregulated following ION-CCI. Pharmacological inhibition of Kv4.3 channels with phrixotoxin-2 inhibited IA-currents in these TG neurons and induced orofacial cold hypersensitivity. On the other hand, pharmacological potentiation of Kv4.3 channels amplified IA currents in these TG neurons and alleviated orofacial cold hypersensitivity in ION-CCI rats. Collectively, Kv4.3 downregulation in nociceptive trigeminal afferent fibers may contribute to peripheral cold hypersensitivity following trigeminal nerve injury, and Kv4.3 activators may be clinically useful to alleviate trigeminal neuropathic pain.

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“…Both of them convey a tactile sensation in the orofacial area. The third spinal nucleus of the CN V is the pars caudalis or trigeminal nucleus caudalis (Christoforou J, 2018, Klasser GD et al, 2018 which carries the pain perception of this involved area. Then the signals will be further projected to the third order neurons in the thalamus via the ventral trigeminothalamic tract (John J, 1990, WC Rivera-Morales ,1986, Joseph G, 1982, Wilkinson JL, 2014, Roberts GJ ,1991, Badel T et.al, 2019, van der Bilt A, 2006.…”

Section: Brainstem Nociceptive Neuronsmentioning

confidence: 99%

Review of Literatures: Physiology of Orofacial Pain in Dentistry

Rotpenpian

Yakkaphan

2021

eNeuro

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The objective of this review of the literature is to summarize the physiology of orofacial pain in dentistry, particularly physiology of the pain pathway and molecular mechanisms on pathophysiology of pain, on account of new insights into classification of orofacial pain related diseases. This article will also focus on possible mechanisms of neuropathic orofacial pain which is distinguished from other types of pain.

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Neuropathic Orofacial Pain

Cited by 20 publications

References 82 publications

Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies

Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies

Kv4.3 Channel Dysfunction Contributes to Trigeminal Neuropathic Pain Manifested with Orofacial Cold Hypersensitivity in Rats

Review of Literatures: Physiology of Orofacial Pain in Dentistry

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