Review of Literatures: Physiology of Orofacial Pain in Dentistry

Rotpenpian, Nattapon; Yakkaphan, Pankeaw

doi:10.1523/eneuro.0535-20.2021

Cited by 17 publications

(21 citation statements)

References 45 publications

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“…In the following sections, we introduce various preclinical models for TMD pain often used, and discuss the characters of the models with the strength and limitations. Further, emphasis is placed in the discussion on the similarities of the features in preclinical models with those in TMD patients [ 6 , 14 , 20 , 22 , [99] , [100] , [101] ].…”

Section: Neural Mechanisms For Pain In the Deep Craniofacial Tissues In Animalsmentioning

confidence: 99%

“…Neural mechanisms in the PNS could be involved in the enhanced deep craniofacial nociception [ 14 , 100 , 101 , 122 ]. The elucidation of molecular basis for the deep craniofacial nociception is beyond the purpose of this article; however, recent findings indicate that peripheral TRPV1 [ 123 ], TRPA1 [ 114 ], TRPM2 [ 124 ], P2 × 3 [ 125 , 126 ], P2Y2 [ 127 ], and orexin [ 128 ] receptors play roles to mediate deep craniofacial nociception in CFA model.…”

Section: Neural Mechanisms For Pain In the Deep Craniofacial Tissues In Animalsmentioning

confidence: 99%

“…CRS also affects neural function in the supra-spinal levels in the CNS. For example, CRS causes neural changes including serotonin (5HT) systems in the raphe magnus nucleus [ 175 , 176 ] of which descending pathways could regulate neural activities in the Vc region [ 14 , 100 , 122 ]. These reports support the notions that CRS-induced hyperalgesia is due to functional changes in the PNS and CNS associated with deep craniofacial nociception.…”

Section: Preclinical Models For Psychological Stress and Deep Craniofacial Pain ( Table 1 )mentioning

confidence: 99%

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Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Okamoto

Hasegawa

Piriyaprasath

et al. 2021

Japanese Dental Science Review

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Section: Neural Mechanisms For Pain In the Deep Craniofacial Tissues In Animalsmentioning

confidence: 99%

Section: Neural Mechanisms For Pain In the Deep Craniofacial Tissues In Animalsmentioning

confidence: 99%

Section: Preclinical Models For Psychological Stress and Deep Craniofacial Pain ( Table 1 )mentioning

confidence: 99%

See 1 more Smart Citation

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Okamoto

Hasegawa

Piriyaprasath

et al. 2021

Japanese Dental Science Review

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“…Orofacial pain (OFP) is the term used to define pain affecting the hard and soft tissues of the face and/or oral cavity [ 1 , 2 ]. Pain is a stimulus modality, it is subjective and serves as a warning sign for response to damaged tissue in the body [ 3 , 4 ]. The prevalence of OFP is reported to be between 16.1 and 33.2%, out of which 10% is considered to contribute to chronic orofacial pain [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Targeted Therapy for Orofacial Pain: A Novel Perspective for Precision Medicine

Raman

Ikutame

Okura

et al. 2023

JPM

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Orofacial pain (OFP) is a dental specialty that includes the diagnosis, management and treatment of disorders of the jaw, mouth, face, head and neck. Evidence-based understanding is critical in effectively treating OFPs as the pathophysiology of these conditions is multifactorial. Since OFP impacts the quality of life of the affected individuals, treating patients successfully is of the utmost significance. Despite the therapeutic choices available, treating OFP is still quite challenging, owing to inter-patient variations. The emerging trends in precision medicine could probably lead us to a paradigm shift in effectively managing the untreatable long-standing pain conditions. Precision medicine is designed based on the patient’s genetic profile to meet their needs. Several significant relationships have been discovered based on the genetics and genomics of pain in the past, and some of the notable targets are discussed in this review. The scope of this review is to discuss preclinical and clinical trials that include approaches used in targeted therapy for orofacial pain. Future developments in pain medicine should benefit from current trends in research into novel therapeutic approaches.

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“…Finally, the information is transmitted to the somatosensory cortex and brain areas involved in memory and affective aspects of pain (amygdala, hypothalamus, etc.) [ 7 , 8 , 9 ]. The development of chronic pain is associated with synaptic plasticity, which causes changes in various areas of the CNS that modulate pain [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Salivary Endocannabinoid Profiles in Chronic Orofacial Pain and Headache Disorders: An Observational Study Using a Novel Tool for Diagnosis and Management

Heiliczer

Wilensky

Gaver

et al. 2022

IJMS

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The endocannabinoid system is involved in physiological and pathological processes, including pain generation, modulation, and sensation. Its role in certain types of chronic orofacial pain (OFP) has not been thoroughly examined. By exploring the profiles of specific salivary endocannabinoids (eCBs) in individuals with different types of OFP, we evaluated their use as biomarkers and the influence of clinical parameters and pain characteristics on eCB levels. The salivary levels of anandamide (AEA), 2-arachidonoyl glycerol (2-AG), and their endogenous breakdown product arachidonic acid (AA), as well as the eCB-like molecules N-palmitoylethanolamide (PEA) and N-oleoylethanolamide (OEA), were assessed in 83 OFP patients and 43 pain-free controls using liquid chromatography/tandem mass spectrometry. Patients were grouped by diagnosis: post-traumatic neuropathy (PTN), trigeminal neuralgia (TN), temporomandibular disorder (TMD), migraine, tension-type headache (TTH), and burning mouth syndrome (BMS). Correlation analyses between a specific diagnosis, pain characteristics, and eCB levels were conducted. Significantly lower levels of 2-AG were found in the TN and TTH groups, while significantly lower PEA levels were found in the migraine group. BMS was the only group with elevated eCBs (AEA) versus the control. Significant correlations were found between levels of specific eCBs and gender, health-related quality of life (HRQoL), BMI, pain duration, and sleep awakenings. In conclusion, salivary samples exhibited signature eCBs profiles for major OFP disorders, especially migraine, TTH, TN, and BMS. This finding may pave the way for using salivary eCBs biomarkers for more accurate diagnoses and management of chronic OFP patients.

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Review of Literatures: Physiology of Orofacial Pain in Dentistry

Cited by 17 publications

References 45 publications

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Targeted Therapy for Orofacial Pain: A Novel Perspective for Precision Medicine

Salivary Endocannabinoid Profiles in Chronic Orofacial Pain and Headache Disorders: An Observational Study Using a Novel Tool for Diagnosis and Management

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