Neurons Are Host Cells for Mycobacterium tuberculosis

Randall, Philippa; Hsu, Nai-Jen; Lang, Dirk; Cooper, S.; Sebesho, Boipelo; Allie, Nasiema; Keeton, Roanne; Francisco, Ngiambudulu M.; Salie, Sumayah; Labuschagné, Antoinette; Quesniaux, Valérie; Ryffel, Bernhard; Kellaway, Lauriston; Jacobs, Muazzam

doi:10.1128/iai.00474-13

Cited by 18 publications

(17 citation statements)

References 51 publications

(36 reference statements)

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“…Microglia within the cerebral parenchyma are the principal CNS cells infected by M.tb and are involved in immune regulation. Other CNS cells that have potential roles in this process are astrocytes and neurons (Fig. ).…”

Section: Pathogenic and Pathophysiologic Mechanisms Within The Brain mentioning

confidence: 99%

“…Randall et al. have demonstrated direct infection of neurons with M.tb ; however, the effect on neuronal function and implications for intercellular interactions is not clear . Although not as prominent as microglia in their role, astrocytes have also been implicated with a study by Rock and colleagues demonstrating 15% of astrocytes having cell‐associated bacilli (average of 1.3 bacilli per cell) compared to 76% of microglia (average of 4.2 bacilli/cell) under the same conditions …”

Section: Pathogenic and Pathophysiologic Mechanisms Within The Brain mentioning

confidence: 99%

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The pathogenesis of tuberculous meningitis

Davis

Rohlwink

Proust

et al. 2019

Journal of Leukocyte Biology

106

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Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M.tb) bacillus disseminates from the primary site of infection and overcomes protective barriers to enter the CNS. There it induces an inflammatory response involving both the peripheral and resident immune cells, which initiates a cascade of pathologic mechanisms that may either contain the disease or result in significant brain injury. Here we review the steps from primary infection to cerebral disease, factors that contribute to the virulence of the organism and the vulnerability of the host and discuss the immune response and the clinical manifestations arising. Priorities for future research directions are suggested. K E Y W O R D S mycobacterial, endothelial cells, granulocytes, microglia cells, monocytes/macrophages, myeloid cells, neutrophils, T Lymphocytes, Th17 cells at the site of infection activates macrophages and DCs to produce cytokines and antimicrobial factors that contribute to containment of the TB bacillus. 2 This inflammatory process results in the formation of a granuloma, which encapsulates the infected cells and retards the replication of TB bacilli and can lead to latent infection. However, in

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Section: Pathogenic and Pathophysiologic Mechanisms Within The Brain mentioning

confidence: 99%

Section: Pathogenic and Pathophysiologic Mechanisms Within The Brain mentioning

confidence: 99%

The pathogenesis of tuberculous meningitis

Davis

Rohlwink

Proust

et al. 2019

Journal of Leukocyte Biology

106

View full text Add to dashboard Cite

show abstract

“…M. tuberculosis bacilli can disseminate from the lung into the central nervous system and the rest of the body. Adipocytes, 70,72 oligodendrocytes and neurons 82 have been found to internalise bacilli and produce cytokines and chemokines.…”

Section: Epithelial Cellsmentioning

confidence: 99%

“…81 However, M. tuberculosis bacilli have been found in other CNS cells, including oligodendrocytes and neurons. [82][83][84] Oligodendrocytes are the myelinating cells in the CNS, like the Schwann cells in the peripheral nervous system. The immunological roles of oligodendrocytes have been mainly focused in multiple sclerosis, 85 although observations of M. tuberculosis invasion in both murine Schwann cells and human oligodendroglial KG-1 cells were reported.…”

Section: Adipocytesmentioning

confidence: 99%

“…[86][87][88][89][90] It was recently demonstrated the association and subsequent internalisation of M. tuberculosis by murine and human-derived neuronal cell lines and primary neurons in culture and in vivo. 82 Neuronal infection elicited a functional neuronal response manifested by elevated cytokine expression. The mechanism of mycobacterial recognition and uptake remains unclear.…”

Section: Adipocytesmentioning

confidence: 99%

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Mycobacterium tuberculosis infection of the ‘non‐classical immune cell’

et al. 2015

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Mycobacterium tuberculosis can infect 'non-classical immune cells', which comprise a significant constituency of cells that reside outside of those defined as 'classical immune cells' from myeloid or lymphoid origin. Here we address the influence of specific 'non-classical immune cells' in host responses and their effects in controlling mycobacterial growth or enabling an environment conducive for bacilli persistence. The interaction of M. tuberculosis with epithelial cells, endothelial cells, fibroblasts, adipocytes, glia and neurons and downstream cellular responses that often dictate immune regulation and disease outcome are discussed. Functional integration and synergy between 'classical' and 'non-classical immune cells' are highlighted as critical for determining optimal immune outcomes that favour the host.

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Application prospects of cerebrospinal fluid DIA techniques in identifying key regulatory molecules for mental disorders in encephalitis

Zhou

Wang

Wen

et al. 2021

Ibrain

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At present, data independent acquisition (DIA) protein spectrum detection technology is one of the most attractive mass spectrometry acquisition techniques, which once led the new development of quantitative proteomics. Its application ields include the screening of clinical disease markers, the study of action mechanism, the study of drug targets and so on. DIA has been wide-ranging used in clinic because of its high throughput, high resolution and high reproducibility. The occurrence of mental disorders in encephalitis is common, and such neurocognitive impairment has a dramatically impact on the disease progression and prognosis of patients, which undoubtedly increases the economic burden of suferers' families and society. Under the circumstance that the mechanism of mental disorder of encephalitis is still unknown, this paper summarizes a large number of literatures of encephalitis, originates the possibility of the application of cerebrospinal luid detection by DIA in the occurrence of mental disorder of encephalitis, seeks for biomarkers for the occurrence of mental disorder of encephalitis, and provides clinical guidance.

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Neurons Are Host Cells for Mycobacterium tuberculosis

Cited by 18 publications

References 51 publications

The pathogenesis of tuberculous meningitis

The pathogenesis of tuberculous meningitis

Mycobacterium tuberculosis infection of the ‘non‐classical immune cell’

Application prospects of cerebrospinal fluid DIA techniques in identifying key regulatory molecules for mental disorders in encephalitis

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