Neuronal substrates of Corsi Block span: Lesion symptom mapping analyses in relation to attentional competition and spatial bias

Chechlacz, Magdalena; Rotshtein, Pia; Humphreys, Glyn W.

doi:10.1016/j.neuropsychologia.2014.09.038

Cited by 43 publications

(23 citation statements)

References 111 publications

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“…With 280 cases and 4 variables in this study, a ratio of 70:1 is very adequate to justify the purposes of PCA. The use of PCA to rotate behavioural data which is then related to the distribution of brain lesions has been demonstrated in recent neuropsychological studies of stroke ( Butler et al, 2014 ; Chechlacz et al, 2014b ) and developmental prosopagnosia ( Garrido et al, 2009 ).…”

Section: Methodsmentioning

confidence: 99%

The relation of object naming and other visual speech production tasks:A large scale voxel-based morphometric study

Lau

Humphreys

Douis

et al. 2015

NeuroImage: Clinical

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We report a lesion–symptom mapping analysis of visual speech production deficits in a large group (280) of stroke patients at the sub-acute stage (<120 days post-stroke). Performance on object naming was evaluated alongside three other tests of visual speech production, namely sentence production to a picture, sentence reading and nonword reading. A principal component analysis was performed on all these tests' scores and revealed a ‘shared’ component that loaded across all the visual speech production tasks and a ‘unique’ component that isolated object naming from the other three tasks. Regions for the shared component were observed in the left fronto-temporal cortices, fusiform gyrus and bilateral visual cortices. Lesions in these regions linked to both poor object naming and impairment in general visual–speech production. On the other hand, the unique naming component was potentially associated with the bilateral anterior temporal poles, hippocampus and cerebellar areas. This is in line with the models proposing that object naming relies on a left-lateralised language dominant system that interacts with a bilateral anterior temporal network. Neuropsychological deficits in object naming can reflect both the increased demands specific to the task and the more general difficulties in language processing.

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Section: Methodsmentioning

confidence: 99%

The relation of object naming and other visual speech production tasks:A large scale voxel-based morphometric study

Lau

Humphreys

Douis

et al. 2015

NeuroImage: Clinical

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“…In the example of aphasia, one could aim to identify common factors in a test battery that represent certain fundamental cognitive processes such as semantic or phonological abilities. Shared factors of correlating variables can be found by dimension reduction techniques, for example, factorial analysis or principal component analysis, and several VLBM studies mapped such common factors (e.g., Aguilar et al, 2018;Butler et al, 2014;Chechlacz et al, 2014;Chen et al, 2016;Fridriksson et al, 2016;Halai et al, 2017;Lau et al, 2015;Timpert et al, 2015;Tochadse et al, 2018;Verdon et al, 2010).…”

mentioning

confidence: 99%

Post‐stroke cognitive deficits rarely come alone: Handling co‐morbidity in lesion‐behaviour mapping

Sperber

Nolingberg

Karnath

2019

Human Brain Mapping

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Post‐stroke behavioural symptoms often correlate and systematically co‐occur with each other, either because they share cognitive processes, or because their neural correlates are often damaged together. Thus, neuropsychological symptoms often share variance. Many previous lesion‐behaviour mapping studies aimed to methodologically consider this shared variance between neuropsychological variables. A first group of studies controlled the behavioural target variable for the variance explained by one or multiple other variables to obtain a more precise mapping of the target variable. A second group of studies focused on the shared variance of multiple variables itself with the aim to map neural correlates of cognitive processes that are shared between the original variables. In the present study, we tested the validity of these methods by using real lesion data and both real and simulated data sets. We show that the variance that is shared between post‐stroke behavioural variables is ambiguous, and that mapping procedures that consider this variance are prone to biases and artefacts. We discuss under which conditions such procedures could still be used and what alternative approaches exist.

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“…A different subset of tests was used to assess function in left versus right hemisphere tumor patients, as domains of impairment have been shown to differ by hemisphere 39 . As a large body of research has supported a right lateralization of spatial working memory and visuospatial attention [40][41][42][43] , right tumor patients were presented with Corsi block span (both forward and backward) 44 as a measure of visuo-spatial short term memory (STM). In forward span, only one patient performed slightly below normal (range: 3.54-5.92; cutoff: 3.75), whereas in backward span, which purportedly engages the central executive to a greater extent, all patients apart from one performed below the cutoff (range: 3.24-5.31; cutoff: 3.75), potentially suggesting a slight general impairment in working memory processing.…”

Section: Motor-evoked Potentials (Meps)mentioning

confidence: 99%

Neurosurgical lesions to sensorimotor cortex do not impair action verb processing

Argiris

Budai

Maieron

et al. 2020

Sci Rep

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There is ongoing debate regarding the role that sensorimotor regions play in conceptual processing, with embodied theories supporting their direct involvement in processing verbs describing body part movements. patient lesion studies examining a causal role for sensorimotor activation in conceptual task performance have suffered the caveat of lesions being largely diffuse and extensive beyond sensorimotor cortices. The current study addresses this limitation in reporting on 20 preoperative neurosurgical patients with focal lesion to the pre-and post-central area corresponding to somatotopic representations. patients were presented with a battery of neuropsychological tests and experimental tasks tapping into motor imagery and verbal conceptual verb processing in addition to neurophysiological measures including DTI, fMRI, and MEP being measured. Results indicated that left tumor patients who presented with a lesion at or near somatotopic hand representations performed significantly worse on the mental rotation hand task and that performance correlated with MEP amplitudes in the upper limb motor region. Furthermore, performance on tasks of verbal processing was within the normal range. Taken together, while our results evidence the involvement of the motor system in motor imagery processes, they do not support the embodied view that sensorimotor regions are necessary to tasks of action verb processing.www.nature.com/scientificreports www.nature.com/scientificreports/ Lesion localization. Contrast-enhanced T1-and T2-weighted MRI scans were performed 7-10 days prior to surgery in order to determine the preoperative tumor location. DTI and anatomical and functional images were acquired from both patients and healthy controls using a Philips Achieva 3-T (Best, Netherlands) scanner. A SENSE-Head-8 channel head coil and a custom-built head restrainer were used to minimize head movements. Scientific RepoRtS |(2020) 10:523 | https://doi.

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Neuronal substrates of Corsi Block span: Lesion symptom mapping analyses in relation to attentional competition and spatial bias

Cited by 43 publications

References 111 publications

The relation of object naming and other visual speech production tasks:A large scale voxel-based morphometric study

The relation of object naming and other visual speech production tasks:A large scale voxel-based morphometric study

Post‐stroke cognitive deficits rarely come alone: Handling co‐morbidity in lesion‐behaviour mapping

Neurosurgical lesions to sensorimotor cortex do not impair action verb processing

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