Neuronal organization and cell interactions of the cat stellate ganglion

Nozdrachev, A. D.; Jiménez, Beatriz; Morales, M.A.; Фатеев, М. М.

doi:10.1016/s1566-0702(01)00360-5

Cited by 14 publications

(17 citation statements)

References 55 publications

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“…the right ganglion is usually wider than the left and has more neuron profiles per area (59.2%). However, left SG neurons are bigger (area and diameter) than the right ones (Nozdrachev et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Asymmetric post‐natal development of superior cervical ganglion of paca (Agouti paca)

Abrahão

Nyengaard

Sasahara

et al. 2008

Intl J of Devlp Neuroscience

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Functional asymmetry has been reported in sympathetic ganglia. Although there are few studies reporting on body side-related morphoquantitative changes in sympathetic ganglion neurons, none of them have used design-based stereological methods to address this issue during post-natal development. We therefore aimed at detecting possible asymmetry-related effects on the quantitative structure of the superior cervical ganglion (SCG) from pacas during ageing, using very precise design-based stereological methods. Forty (twenty left and twenty right) SCG from twenty male pacas were studied at four different ages, i.e. newborn, young, adult and aged animals. By using design-based stereological methods the total volume of ganglion and the total number of mononucleate and binucleate neurons were estimated. Furthermore, the mean perikaryal volume of mononucleate and binucleate neurons was estimated, using the vertical nucleator. The main findings of this study were: (1) the right SCG from aged pacas has more mononucleate and binucleate neurons than the left SCG in all other combinations of body side and animal age, showing the effect of the interaction between asymmetry (right side) and animal age, and (2) right SCG neurons (mono and binucleate) are bigger than the left SCG neurons (mono and binucleate), irrespective of the animal age. This shows, therefore, the exclusive effect of asymmetry (right side). At the time of writing there is still no conclusive explanation for some SCG quantitative changes exclusively assigned to asymmetry (right side) and those assigned to the interaction between asymmetry (right side) and senescence in pacas. We therefore suggest that forthcoming studies should focus on the functional consequences of SCG structural asymmetry during post-natal development. Another interesting investigation would be to examine the interaction between ganglia and their innervation targets using anterograde and retrograde neurotracers. Would differences in the size of target organs explain ganglia structural asymmetry?

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Section: Introductionmentioning

confidence: 99%

Asymmetric post‐natal development of superior cervical ganglion of paca (Agouti paca)

Abrahão

Nyengaard

Sasahara

et al. 2008

Intl J of Devlp Neuroscience

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“…Taking into account the mechanism of homotropic regulation [5], similar changes in activity of anodic and cathodic fractions exclude the possibility of substrate inhibition. However, dysfunction of ionotropic N-CL synapses that accompanies blockade is followed by changes in ion homeostasis [6]. Published data show that LDH is highly sensitive to pH of the medium [5].…”

Section: Resultsmentioning

confidence: 99%

“…Among a variety of neurotransmitters systems, the nicotinic cholinergic (N-CL) system plays a special role, because processes occurring in N-CL synapses serve as the initial stage of other synaptic process (at least in autonomic ganglia) [2,6]. Taking into account the functional significance of N-CL synapses, it is important to evaluate their role in the metabolism in nervous tissue.…”

mentioning

confidence: 99%

Isoenzyme profile of lactate dehydrogenase in the cranial cervical sympathetic ganglion under normal conditions and during synaptic blockade

Gorelikov

Savel’ev

2005

Bull Exp Biol Med

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The isoenzyme profile of lactate dehydrogenase in the cranial cervical sympathetic ganglion of rabbits was studied under normal conditions and during blockade of nicotinic cholinergic synapses. Under normal conditions this profile was presented by 5 isoforms of the enzyme (lactate dehydrogenases 1, 2, 3, 4, and 5). Activity of H-isoforms prevailed. Blockade was accompanied by heterotropic allosteric inhibition of lactate dehydrogenase isoforms. H- and M-isoforms underwent simultaneous changes. Activity of H-isoforms sharply decreased. However, the ratio between lactate dehydrogenases 1 and 2 during complete or partial blockade did not differ from that observed in experiments with the intact ganglion. M-isoforms (lactate dehydrogenases 4 and 5) disappeared during partial blockade. Activity of hybrid lactate dehydrogenase 3 significantly decreased and was undetected during partial and complete blockade, respectively. Our results indicate that enzyme activity and isoenzyme profile of lactate dehydrogenase are determined by function of nicotinic synapses.

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“…Based on numerous experiments with denervation of the interscapular pads in rodents, as well as pharmacological studies using ß3-adrenergic agonists and blockers, the main driver of BAT thermogenesis seems to be its noradrenergic sympathetic innervation (Andrews et al 1985; Bartness and Wade 1984; Himms-Hagen et al 1990; Takahashi et al 1992; Tsukazaki et al 1995). Retrograde tracing and other studies in rats and Siberian hamsters have identified postganglionic perikarya innervating BAT in the stellate ganglia (Grkovic and Anderson 1997; Oldfield et al 2002), known to receive input from preganglionic neurons in the intermediolateral cell column of the cervical and thoracic spinal cord (Nozdrachev et al 2002; Tanche and Therminarias 1967) (Fig. 4).…”

Section: Input and Output Systems For Energy Expenditure Controlmentioning

confidence: 93%

Neural Control of Energy Expenditure

et al. 2015

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The continuous rise in obesity is a major concern for future healthcare management. Many strategies to control body weight focus on a permanent modification of food intake with limited success in the long term. Metabolism or energy expenditure is the other side of the coin for the regulation of body weight, and strategies to enhance energy expenditure are a current focus for obesity treatment, especially since the (re)-discovery of the energy depleting brown adipose tissue in adult humans. Conversely, several human illnesses like neurodegenerative diseases, cancer, or autoimmune deficiency syndrome suffer from increased energy expenditure and severe weight loss. Thus, strategies to modulate energy expenditure to target weight gain or loss would improve life expectancies and quality of life in many human patients. The aim of this book chapter is to give an overview of our current understanding and recent progress in energy expenditure control with specific emphasis on central control mechanisms.

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Neuronal organization and cell interactions of the cat stellate ganglion

Cited by 14 publications

References 55 publications

Asymmetric post‐natal development of superior cervical ganglion of paca (Agouti paca)

Asymmetric post‐natal development of superior cervical ganglion of paca (Agouti paca)

Isoenzyme profile of lactate dehydrogenase in the cranial cervical sympathetic ganglion under normal conditions and during synaptic blockade

Neural Control of Energy Expenditure

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