Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis

Beyeler, Anna; Dabrowska, Joanna

doi:10.1016/b978-0-12-815134-1.00003-9

Cited by 51 publications

(50 citation statements)

References 381 publications

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“…This peptidergic heterogeneity of inhibitory neurons allows for multilevel gating of behavioural outputs by modulating tonic inhibition of CeM effector neurons (Ciocchi et al, 2010). Much knowledge of the CeA microcircuitry has come from electrophysiological and optogenetic dissection of fear circuits (Babaev et al, 2018;Beyeler & Dabrowska, 2020). Most widely studied are two distinct populations of CeC/CeL cells that can be distinguished by their expression of either protein kinase C δ (PKC δ) or somatostatin (SST) (Haubensak et al, 2010;Hunt et al, 2017).…”

Section: Centr Al Amyg Dal a MI Cro Circu Itrymentioning

confidence: 99%

A balancing act: the role of pro‐ and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders

Walker

2021

Journal of Neurochemistry

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Abbreviations: 2-AG, 2-arachidonoylglycerol; 5-HT 1A , serotonin 1A receptor; 5-HT 1B , serotonin 1A receptor; 5-HT 2A (Htr2a), serotonin 2A receptor; 5-HT 3 , serotonin 3 receptor; AEA, anandamide; AR, adrenoceptors; AUD, alcohol use disorder; BA, basal nucleus of the amygdala; BLA, basolateral nucleus of the amygdala; BMA, basomedial nucleus of the amygdala; BNST, bed nucleus of the stria terminalis; CALCRL (Calcrl), calcitonin receptor-like; CART (Cartpt), cocaine and amphetamine regulated transcript; CB 1 , cannabinoid type 1; CB 2 , cannabinoid type 2; CeA, central nucleus of the amygdala; CeC, capsular division of the CeA; CeL, lateral division of the CeA; CeM, medial division of the CeA; CNS, central nervous system; CoA, cortical nucleus of the amygdala; CRF (Crh), corticotrophin releasing factor; CRF 1 (Crhr1), CRF receptor 1; D 1 R (Drd1), dopamine D1 receptor; D 2 R (Drd2), dopamine D2 receptor; EGFP, enhanced green fluorescent protein; FAAH, fatty acid amide hydrolase; FISH, fluorescent in-situ hybridization; GAL 1 , galanin 1 receptor; GAL 2 , galanin 2 receptor; GAL 3 , galanin 3 receptor; GPCR, G protein-coupled receptors; HPA, hypothalamic-pituitary-adrenal axis; IEG, early immediate gene; IHC, immunohistochemistry; IPSC, inhibitory postsynaptic potentials; ITC, intercalated cells of the amygdala; KO, knockout; LA, lateral basal nucleus of the amygdala; LC, locus coeruleus; LDB, light-dark box LH, lateral hypothalamus; MAGL, monoacylglycerol lipase; MeA, medial nucleus of the amygdala; mSP, Marchigian Sardinian alcohol-preferring rat; N/O-FQ

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Section: Centr Al Amyg Dal a MI Cro Circu Itrymentioning

confidence: 99%

A balancing act: the role of pro‐ and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders

Walker

2021

Journal of Neurochemistry

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“…Optogenetic stimulation of OT release in the CeA prior to testing reduced freezing responses, an effect abolished by OTA ( Knobloch et al, 2012 ). Both of these studies suggest that OT (either via injection or optogenetically stimulated release) primarily activates CeL neurons, which in turn increases GABA-ergic inhibition in PAG-projecting CeM output neurons, leading to the attenuation of contextual fear responses (for details on the OT-modulated neurocircuitry, see Beyeler and Dabrowska, 2020 ). In contrast to the study by Knobloch and colleagues (2012) in female rats, infusion of OT at various doses (0.6, 3, 15, and 75 ng) in the CeA of male rats before the first recall test resulted in higher levels of freezing during the test ( Campbell-Smith et al, 2015 ).…”

Section: The Effects Of Oxytocin In the Regulation Of Contextual Fearmentioning

confidence: 99%

Oxytocin Promotes Accurate Fear Discrimination and Adaptive Defensive Behaviors

Olivera-Pasilio

Dabrowska

2020

Front. Neurosci.

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“…One reductionist approach to understanding amygdala computation lies in identifying functional contributions of specific amygdalar regions ( Beyeler and Dabrowska, 2020 ). The basolateral amygdala complex (BLA) is one region that has received particular attention, in large part due to its high degree of reciprocal long-range connectivity with other brain regions ( Amir et al, 2018 ; Janak and Tye, 2015 ; Little and Carter, 2013 ; McGarry and Carter, 2017 ; Senn et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala

O’Leary

Sullivan

Wang

et al. 2020

eLife

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The basolateral amygdala complex (BLA), extensively connected with both local amygdalar nuclei as well as long-range circuits, is involved in a diverse array of functional roles. Understanding the mechanisms of such functional diversity will be greatly informed by understanding the cell-type-specific landscape of the BLA. Here, beginning with single-cell RNA sequencing, we identified both discrete and graded continuous gene-expression differences within the mouse BLA. Via in situ hybridization, we next mapped this discrete transcriptomic heterogeneity onto a sharp spatial border between the basal and lateral amygdala nuclei, and identified continuous spatial gene-expression gradients within each of these regions. These discrete and continuous spatial transformations of transcriptomic cell-type identity were recapitulated by local morphology as well as long-range connectivity. Thus, BLA excitatory neurons are a highly heterogenous collection of neurons that spatially covary in molecular, cellular, and circuit properties. This heterogeneity likely drives pronounced spatial variation in BLA computation and function.

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Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis

Cited by 51 publications

References 381 publications

A balancing act: the role of pro‐ and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders

A balancing act: the role of pro‐ and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders

Oxytocin Promotes Accurate Fear Discrimination and Adaptive Defensive Behaviors

Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala

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