A balancing act: the role of pro‐ and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders

Walker, Leigh C.

doi:10.1111/jnc.15301

Cited by 27 publications

(30 citation statements)

References 278 publications

(365 reference statements)

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“…Even though the inhibition of Y1 receptor containing CeA neurons projecting to the lateral habenula had a behavioral effect, there were no changes to the inhibitory currents in these neurons after one 4-day cycle of binge-like alcohol consumption (Companion et al, 2022). Overall, these findings show the involvement of NPY on alcohol related behavioral and physiological effects (for a more comprehensive review of the effect of NPY CRFR1 and CRFR2 required to block effect of alcohol on glutamatergic transmission in CeA CRFR1 antagonists reduce alcohol consumption (Finn et al, 2007;Lowery-Gionta et al, 2012;Weera et al, 2020;Walker, 2021) Neuropeptide Y (NPY) CeA M Projections to and from intercalated neurons, BNST…”

Section: Neuropeptide Ymentioning

confidence: 64%

“…To better understand the mechanisms of action of alcohol on the CeA and its specific subregions, it is important to look at the neuropeptide composition of these subregions and their role in alcohol use ( Table 5 ). Below, we will briefly touch on some of the common peptides and their roles in AUD (for more comprehensive reviews please see Gilpin, 2012b ; Silberman and Winder, 2013 ; Gilpin et al, 2015 ; Walker, 2021 ).…”

Section: Modulators Of Proposed Circuitmentioning

confidence: 99%

“…In msP rats exposed to two-bottle choice paradigm, CRF application led to an increase in spontaneous action potential-independent GABAergic activity, similar to naïve msP rats, while CRFR1 antagonist abolished this increase in two-bottle choice exposed msP rats ( Herman et al, 2013 ). Behaviorally, CRFR1 receptor antagonists reduce both alcohol consumption and alcohol withdrawal induced irritability-like behaviors in animal models ( Finn et al, 2007 ; Lowery-Gionta et al, 2012 ; Kimbrough et al, 2017 ; Weera et al, 2020 ; Walker, 2021 ). Stimulation of the neurons projecting from CeA to nucleus accumbens leads to reduction in binge-like alcohol drinking, and this effect is mediated by CRFR1 activity ( Borrego et al, 2022 ).…”

Section: Modulators Of Proposed Circuitmentioning

confidence: 99%

“…Nociceptin acts through the nociceptin/orphanin FQ Opioid Peptide Receptor (NOP) and can have effects on alcohol-related behaviors ( Witkin et al, 2014 ; Walker, 2021 ). Oral administration of NOP antagonist led to a significant reduction in alcohol intake through the two-bottle choice paradigm, particularly in females ( Borruto et al, 2020 ).…”

Section: Modulators Of Proposed Circuitmentioning

confidence: 99%

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Subregional Differences in Alcohol Modulation of Central Amygdala Neurocircuitry

Melkumyan

Silberman

2022

Front. Mol. Neurosci.

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Alcohol use disorder is a highly significant medical condition characterized by an impaired ability to stop or control alcohol use, compulsive alcohol seeking behavior, and withdrawal symptoms in the absence of alcohol. Understanding how alcohol modulates neurocircuitry critical for long term and binge-like alcohol use, such as the central amygdala (CeA), may lead to the development of novel therapeutic strategies to treat alcohol use disorder. In clinical studies, reduction in the volume of the amygdala has been linked with susceptibility to relapse to alcohol use. Preclinical studies have shown the involvement of the CeA in the effects of alcohol use, with lesions of the amygdala showing a reduction in alcohol drinking, and manipulations of cells in the CeA altering alcohol drinking. A great deal of work has shown that acute alcohol, as well as chronic alcohol exposure via intake or dependence models, alters glutamatergic and GABAergic transmission in the CeA. The CeA, however, contains heterogeneous cell populations and distinct subregional differences in neurocircuit architecture which may influence the mechanism by which alcohol modulates CeA function overall. The current review aimed to parse out the differences in alcohol effects on the medial and lateral subregions of the CeA, and what role neuroinflammatory cells and markers, the endocannabinoid system, and the most commonly studied neuropeptide systems play in mediating these effects. A better understanding of alcohol effects on CeA subregional cell type and neurocircuit function may lead to development of more selective pharmacological interventions for alcohol use disorder.

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Section: Neuropeptide Ymentioning

confidence: 64%

Section: Modulators Of Proposed Circuitmentioning

confidence: 99%

Section: Modulators Of Proposed Circuitmentioning

confidence: 99%

Section: Modulators Of Proposed Circuitmentioning

confidence: 99%

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Subregional Differences in Alcohol Modulation of Central Amygdala Neurocircuitry

Melkumyan

Silberman

2022

Front. Mol. Neurosci.

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“…A global prevalence of alcohol dependence among 2.4 billion alcohol drinkers was up to 39.60%, which represents a considerable public health burden ( 2 ). Moreover, alcohol dependence shares a high co-morbidity with anxiety-related disorders ( 3 , 4 ). Furthermore, those with comorbid anxiety and alcohol dependence typically have a poorer psychosocial functioning, physical health, and ultimately cause serious consequences including divorce, crime, self-harm, and suicide tendency, especially in the context of alcohol withdrawal ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

The Interaction Between POMC rs2071345 Polymorphism and Alcohol Dependence in Anxiety Symptoms Among Chinese Male Problem Drinkers

et al. 2022

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ObjectiveAlcohol dependence can increase the level of anxiety. A growing body of research has identified a link between anxiety symptoms of problem drinkers and their genetic or environment factors, respectively. However, to date few studies have directly examined gene-environment (G × E) interaction on their anxiety symptoms during the acute alcohol withdrawal. The present study aims to examine the interaction between the proopiomelanocortin (POMC) rs2071345 polymorphism and alcohol dependence on anxiety symptoms of male problem drinkers, and further test the exact form of interaction on two competing models: the diathesis-stress model vs. the differential susceptibility model.MethodsA total of 440 male problem drinkers (Mage = 44.5 years, SD = 9.45) were recruited from nine main psychiatric hospitals of northern China during acute alcohol withdrawal. Blood samples were collected for genotyping, self-reported anxiety symptoms, and levels of alcohol dependence were assessed.ResultsResults indicated that the POMC rs2071345 polymorphism significantly moderated anxiety symptoms associated with alcohol dependence. A region of significance (RoS) test showed that male problem drinkers with T allele were more likely to experience more anxiety symptoms than those with CC homozygote when the standardized score of concurrent alcohol dependence was above 0.31. Confirmatory model evaluation indicated that the interaction effect involving POMC gene polymorphism conformed to the diathesis-stress model rather than differential-susceptibility model of person × environment interaction.ConclusionsThis study suggested that the SNP in POMC rs2071345 was associated with alcohol dependence in anxiety symptoms of male problem drinkers and further provided evidence in support of the diathesis-stress hypothesis of alcohol dependence in terms of anxiety symptoms.

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Four hypothalamic peptides and their impact on drug-seeking behaviour: A prefrontal cortex view

Perry¹,

Cornish²

2022

Addiction Neuroscience

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A balancing act: the role of pro‐ and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders

Cited by 27 publications

References 278 publications

Subregional Differences in Alcohol Modulation of Central Amygdala Neurocircuitry

Subregional Differences in Alcohol Modulation of Central Amygdala Neurocircuitry

The Interaction Between POMC rs2071345 Polymorphism and Alcohol Dependence in Anxiety Symptoms Among Chinese Male Problem Drinkers

Four hypothalamic peptides and their impact on drug-seeking behaviour: A prefrontal cortex view

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