Neuronal discharges of the ventrolateral nucleus of the thalamus during sleep and wakefulness in the cat II. Evoked activity

Filion, M.; Lamarre, Y.; Cordeau, J. Pierre

doi:10.1007/bf00234245

Cited by 42 publications

(8 citation statements)

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“…Furthermore, the cells of the reticular nucleus have an inhibitory influence on the thalamocortical relay cells in the ventral group of nuclei (Mukhametov et al, 1970;Filion et al, 1971;Schlag and Waszak, 1971;Frygyesi and Schwartz, 1972;Steriade and Wyzinski, 1972).…”

Section: Discussionmentioning

confidence: 99%

Glutamic acid decarboxylase-immunoreactive neurons and horseradish peroxidase-labeled projection neurons in the ventral posterior nucleus of the cat and Galago senegalensis

Penny¹,

Fitzpatrick²,

Schmechel³

et al. 1983

J. Neurosci.

116

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Immunocytochemical methods were used to identify neurons in the ventral posterior nucleus of the cat and Galago senegalensis that contain glutamic acid decarboxylase (GAD), the synthetic enzyme for the inhibitory neurotransmitter, GABA. In both species GAD-immunoreactive neurons make up about 30% of the total neurons in the ventral posterior nucleus and form a distinct class of small cells. After cortical injections of horseradish peroxidase (HRP), GAD-immunoreactive cells are not labeled with HRP and may, therefore, be GABAergic local circuit neurons. Comparison of the dendritic morphology of GAD-immunoreactive neurons with that of HRP-filled projection neurons reveals that the morphology of the GAD-containing neurons is distinct and, in particular, that the GAD-immunoreactive neurons display fewer primary dendrites. The relay neurons, in turn, can be divided into classes based on dendritic morphology and cell body size.The idea that thalamic neurons could be divided into classes based on morphological criteria has a long history. According to Rambn y Cajal (1909, the most fundamental distinction was between the neurons with long axons that project to the cerebral cortex and neurons with short axons that were thought to be local circuit neurons. Cajal found the neurons with short axons or "cellules 6 cylindre-axe court" to be distributed widely in the nervous system and to be especially numerous in the thalamus and neocortex of higher mammals. The neurons with long axons (or projection neurons) could be further subdivided into classes based on their appearance in Golgi material. T6mb61 recently (1967) identified at least two classes in the case of the somatosensory ventral posterior nucleus of the cat.

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Section: Discussionmentioning

confidence: 99%

Glutamic acid decarboxylase-immunoreactive neurons and horseradish peroxidase-labeled projection neurons in the ventral posterior nucleus of the cat and Galago senegalensis

Penny¹,

Fitzpatrick²,

Schmechel³

et al. 1983

J. Neurosci.

116

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“…This is indeed the case, as demonstrated by testing with antidromic and monosynaptic volleys . The lower probability of single-spike discharges evoked by synaptic volleys during e.e.g.-synchronized sleep is associated with occasional burst responses during this state (Filion, Lamarre & Cordeau, 1971;Steriade et al 1971;MacLeod & James, 1984).…”

Section: Discussionmentioning

confidence: 99%

Thalamic burst patterns in the naturally sleeping cat: a comparison between cortically projecting and reticularis neurones.

Domich¹,

Oakson²,

Steriade³

1986

The Journal of Physiology

234

157

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SUMMARY1. Unit discharges were extracellularly recorded from antidromically identified thalamocortical neurones of ventralis lateralis (v.1.) and centralis lateralis (c.l.) nuclei as well as from reticularis thalami (re.) neurones during wakefulness and electroencephalogram-synchronized sleep of the behaving cat. Various parameters of sleep-related discharge bursts were analysed.2. Statistical analyses revealed striking similarities between motor relay (v.1.) and intralaminar (c.l.) neurones. More than 60 % of bursts consist of three to five spikes at 250-400 Hz. The defining feature of bursts in all cortically projecting neurones is a progressive increase in the duration of successive interspike intervals. 3. As in thalamocortical cells, all re. neurones change their tonic discharges in waking to bursting firing in sleep, regardless of the increased or decreased firing rates from wake to sleep in individual neurones. The bursts of re. neurones are essentially different from those of thalamocortical cells. In re. neurones, burst structure consists of an initial progressive decrease in duration of interspike intervals, followed by an increase in duration of successive intervals, eventually leading to a long-lasting tonic spike train at about 100 Hz. In contrast with bursts of thalamocortical neurones, only 6 % of re. bursts are shorter than 50 ms; the total duration of the burst extends between 50 ms and 1'5 s. Population periburst histograms show the beginning of a decline in firing probability about 1-5 s prior -to burst onset and an increased firing probability persisting for 300-350 ms after burst onset.4. The different electrophysiological properties underlying the burst structure of cat's thalamocortical and re. neurones are discussed, with emphasis on dissimilar aspects of re. bursts in unanaesthetized and barbituratized preparations. Various factors that may account for the transition from tonic mode in waking to bursting mode in sleep are envisaged.

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“…This finding is consistent with the anatomical observation that ascending fibres from the fastigial nucleus terminate bilaterally in these regions of the thalamus (ANGAUT and BOWSHER, 1970;NAKANO et a!.,1980;SUGIMOTO et a!.,1981) and also with the report that thalamocortical projection fibres originating from these thalamic areas terminate in the medial precruciate cortex and the rostromedial portion of the ventral bank of the cruciate sulcus (NAKANO et al, 1978;STRICK, 1973;VEDOVATO, 1978). The observed tendency of thalamic neurones to repetitive spike generation would be a feature reflecting the effects of anesthesia, since cerebellar stimulation usually evokes a single spike with short latencies in the thalamus of the waking unanesthetized cat (FILLION et al, 1971;STERIADE et al, 1971). To the repetitive activation of thalamic neurones might be relevant the occurrence of EPSPs with longer latencies after stimulation of the fastigial nucleus (MATSUDA and NAKAMURA, 1982).…”

Section: Discussionmentioning

confidence: 87%

Re-evaluation of cortical and thalamic responses evoked by stimulation of the cerebellar fastigial nucleus in the cat.

Nakamura

Matsuda²

1983

Jpn.J.Physiol

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Neuronal discharges of the ventrolateral nucleus of the thalamus during sleep and wakefulness in the cat II. Evoked activity

Cited by 42 publications

References 0 publications

Glutamic acid decarboxylase-immunoreactive neurons and horseradish peroxidase-labeled projection neurons in the ventral posterior nucleus of the cat and Galago senegalensis

Glutamic acid decarboxylase-immunoreactive neurons and horseradish peroxidase-labeled projection neurons in the ventral posterior nucleus of the cat and Galago senegalensis

Thalamic burst patterns in the naturally sleeping cat: a comparison between cortically projecting and reticularis neurones.

Re-evaluation of cortical and thalamic responses evoked by stimulation of the cerebellar fastigial nucleus in the cat.

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