Neuron-Specific Enolase as an Immunohistochemical Marker Is Better Than Its Reputation

Mjønes, Patricia; Sagatun, Liv; Nordrum, Ivar Skjåk; Waldum, Helge L.

doi:10.1369/0022155417733676

Cited by 43 publications

(40 citation statements)

References 37 publications

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“…[12][13][14] In addition, extracerebral sources of NSE may cause bias: high NSE concentrations have been found in association with several diseases, including small cell lung cancer 9 and many neuroendocrine tumors. 37 Therefore, it is advisable to avoid decisions about futility of care on the basis of NSE concentrations alone. Nevertheless, NSE is a useful part of multimodal prognostication based on repeated clinical examination, electrophysiological studies and brain imaging.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of neuron specific enolase in prognostication after cardiac arrest: Impact of age and time to ROSC

et al. 2019

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Aim of the study: We evaluated the impact of patient age and time from collapse to return of spontaneous circulation (ROSC) on the prognostic accuracy of neuron specific enolase (NSE) after out-of-hospital cardiac arrest (OHCA). Methods: Using electrochemiluminescence immunoassay, we measured serum concentrations of NSE in 249 patients who were admitted to intensive care units after resuscitation from OHCA. In each quartile according to age and time to ROSC, we evaluated the ability of NSE at 48 h after OHCA to predict poor outcome (Cerebral Performance Category 3-5) at 12 months. Results: The outcome at 12 months was poor in 121 (49%) patients. The prognostic performance of NSE was excellent (area under the receiver operating characteristic curve, AUROC, 0.91 [95% confidence interval, 0.81-1.00]) in the youngest quartile (18-56 years), but worsened with increasing age, and was poor (AUROC 0.53 [0.37-0.70]) in the oldest quartile (72 years or more). The prognostic performance of NSE was worthless (AUROC 0.45 [0.30-0.61]) in the quartile with the shortest time to ROSC (1-13 min), but improved with increasing time to ROSC, and was good (AUROC 0.84 [0.74-0.95]) in the quartile with the longest time to ROSC (29 min or over). Conclusion: NSE at 48 h after OHCA is a useful predictor of 12-month-prognosis in young patients and in patients with a long time from collapse to ROSC, but not in old patients or patients with a short time to ROSC.

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Section: Discussionmentioning

confidence: 99%

Usefulness of neuron specific enolase in prognostication after cardiac arrest: Impact of age and time to ROSC

et al. 2019

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“…However NSE also associated with such pathologies as small cell lung cancer, neuroblastoma, neuroendocrine tumours, melanoma, seminoma, renal cell carcinoma, Merkel cell tumour, carcinoid tumours, dysgerminomas, malignant phaechromocytoma and immature teratomas. 9 These data added extra requirements for the inclusion and exclusion of patients in the study in order to avoid the presence of patients with benign and malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

Neuron- specific enolase level in patients with metabolic syndrome and its value forecasting acute stroke

Ospanov¹,

Ospanova²,

Kadyrova³

2018

AMJ

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RESEARCHPlease cite this paper as: Ospanov O, Ospanova K, Kadyrova I. Neuron-specific enolase level in patients with metabolic syndrome and its value forecasting acute stroke. AMJ 2018;11(3):186-194. ABSTRACT BackgroundPatients with metabolic syndrome are at a greater risk of experiencing a cerebrovascular event. Several studies show that patients with metabolic syndrome have asymptomatic ischemic brain injury. In this case, there is a need for rapid determination of asymptomatic brain lesions and prediction of acute stroke. AimsThe aim of the study was to determine the neuron-specific enolase (NSE) serum level in patients with metabolic syndrome and the value of this level for forecasting acute stroke. MethodsThe study used the following information to determine metabolic syndrome: waist circumference, total cholesterol, triglycerides, high-density lipoprotein cholesterol, blood pressure, and blood glucose. Doppler sonography mapping of the brachiocephalic trunk was held to determine the percentage of the carotid artery stenosis. To determine asymptomatic ischemic brain injury, the NSE serum marker was measured. Statistical processing of the measurements was performed using the H test and the Mann-Whitney test. The possible link between MS and NSE were determined by logistic regression analysis. Mathematical modeling was performed using logistic regression. ResultsThere are statistically significant differences in NSE concentrations in groups with metabolic syndrome and ischemic stroke patients. This assertion is confirmed by logistic regression analysis, which revealed the existence of a relationship between metabolic syndrome and increased concentration of NSE. ConclusionPatients with metabolic syndrome have an increased concentration of NSE. This indicates the presence of asymptomatic ischemic neuronal damage. A prognostic model for determining the probability that patients with metabolic syndrome will have an acute stroke was developed.

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“…All tumours ought to be examined for endocrine differentiation by immunohistochemistry with antibodies towards general NE markers like chromogranin A and synaptophysin. NSE is also a sensitive marker, and its specificity is better than generally believed [83]. Finally, the detection of gastrin receptor by immunohistochemistry and especially by in-situ hybridization, will also demonstrate a possible role of gastrin in the carcinogenesis and a possible treatment strategy.…”

Section: Discussionmentioning

confidence: 99%

Types of Gastric Carcinomas

Waldum

Fossmark

2018

IJMS

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Gastric cancer has reduced prevalence, but poor prognoses. To improve treatment, better knowledge of carcinogenesis and cells of origin should be sought. Stomach cancers are typically localized to one of the three mucosae; cardial, oxyntic and antral. Moreover, not only the stem cell, but the ECL cell may proliferate and give rise to tumours. According to Laurén, the classification of gastric carcinomas seems to reflect biological important differences and possible different cell of origin since the two subtypes, intestinal and diffuse, do not transform into the other and show different epidemiology. The stem cell probably gives rise to the intestinal type, whereas the ECL cell may be important in the diffuse type. Elevation of gastrin may be the carcinogenic factor for Helicobacter pylori as well as the recently described increased risk of gastric cancer due to proton pump inhibitor treatment. Therefore, it is essential to determine the role of the gastrin target cell, the ECL cell, in gastric carcinogenesis. Clinical trials with gastrin antagonists could improve prognoses in those with gastrin receptor positive tumours. However, further studies on gastric carcinomas applying relative available methods and with the highest sensitivity are warranted to improve our knowledge of gastric carcinogenesis.

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Neuron-Specific Enolase as an Immunohistochemical Marker Is Better Than Its Reputation

Cited by 43 publications

References 37 publications

Usefulness of neuron specific enolase in prognostication after cardiac arrest: Impact of age and time to ROSC

Usefulness of neuron specific enolase in prognostication after cardiac arrest: Impact of age and time to ROSC

Neuron- specific enolase level in patients with metabolic syndrome and its value forecasting acute stroke

Types of Gastric Carcinomas

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