Neuron-Glia Interrelations During 3-Acetylpyridine-Induced Degeneration and Regeneration in the Adult Lizard Brain

Font, Enrique; García‐Verdugo, José Manuel; Desfilis, Ester; Pérez-Cañellas, Mar

doi:10.1385/0-89603-316-3:275

Cited by 3 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the cerebral cortex, their numbers are estimated at less than 5%. They include microglial cells with a distinctly laminar pattern of distribution and oligodendroglial cells in areas with myelinated fibers [García-Verdugo et al, 1981;Yanes et al, 1992;Font et al, 1995]. No GFAP-positive astrocytes have been observed in the intact telencephalon of lizards [Dahl et al, 1985;Yanes et al, 1990;Pérez-Cañellas and García-Verdugo, 1996; but see Monzó n-Mayor et al., 1990].…”

Section: Cell Types Born In the Adult Telencephalonmentioning

confidence: 99%

“…However, routine light and electron microscopic techniques, as well as degeneration-sensitive silver impregnation procedures, have failed to detect neuronal death in the telencephalon of adult lizards and turtles [Ló pez-García et al, 1990a;Font et al, 1995Font et al, , 1997. This suggests that the neurons born in the brain of adult reptiles represent a net addition to already existing populations, rather than a replacement for older neurons.…”

Section: Cell Types Born In the Adult Telencephalonmentioning

confidence: 99%

See 1 more Smart Citation

Neurogenesis and Neuronal Regeneration in the Adult Reptilian Brain

Font¹,

Desfilis²,

et al. 2001

Self Cite

View full text Add to dashboard Cite

Evidence accumulated over the last few decades demonstrates that all reptiles examined thus far continue to add neurons at a high rate and in many regions of the adult brain. This so-called adult neurogenesis has been described in the olfactory bulbs, rostral forebrain, all cortical areas, anterior dorsal ventricular ridge, septum, striatum, nucleus sphericus, and cerebellum. The rate of neuronal production varies greatly among these brain areas. Moreover, striking differences in the rate and distribution of adult neurogenesis have been noted among species. In addition to producing new neurons in the adult brain, lizards, and possibly other reptiles as well, are capable of regenerating large portions of their telencephalon damaged as a result of experimentally-induced injuries, thus exhibiting an enormous potential for neuronal regeneration. Adult neurogenesis and neuronal regeneration take advantage of the same mechanisms that are present during embryonic neurogenesis. New neurons are born in the ependyma lining the ventricles and migrate radially through the brain parenchyma along processes of radial glial cells. Several lines of evidence suggest that radial glial cells also act as stem cells for adult neurogenesis. Once they reach their final destination, the young neurons extend axons that reach appropriate target areas. Tangential migration of neurons alongside the ventricular ependyma has also been reported. Most of these tangentially migrating neurons seem to be destined for the olfactory bulbs and are, thus, part of a system similar to the mammalian rostral migratory stream. The proliferation and recruitment of new neurons appear to result in continuous growth of most areas showing adult neurogenesis. The functional consequences of this continuous generation and integration of new neurons into existing circuits is largely conjectural, but involvement of these phenomena in learning and memory is one likely possibility.

show abstract

Section: Cell Types Born In the Adult Telencephalonmentioning

confidence: 99%

Section: Cell Types Born In the Adult Telencephalonmentioning

confidence: 99%

Neurogenesis and Neuronal Regeneration in the Adult Reptilian Brain

Font¹,

Desfilis²,

et al. 2001

Self Cite

View full text Add to dashboard Cite

show abstract

“…Radial glial cells in the VZ are likely the stem cells for adult neurogenesis in reptiles but evidence supporting this hypothesis in reptile studies is limited (Font et al, 1995b).…”

Section: Proliferationmentioning

confidence: 99%

“…In adult lizards, neuron proliferation and migration in the medial cortex are increased after lesioning with the neurotoxin 3-acetlypyridine (3AP) (Font et al, 1995b;Font et al, 1991;Kaslin et al, 2008). The damage from 3AP varies greatly among lizards of the same species (for both P. hispanica and Anolis carolinensis) and between regions.…”

Section: Regeneration In the Adult Telencephalonmentioning

confidence: 99%