Neuromuscular disorders and non compaction: How much is the strength of the association and how can it be suspected?

Thorough search for myopathy increases the prevalence of noncompaction

“…The contribution by Fazio et al on the association of left ventricular hypertrabeculation/noncompaction (LVHT) with neuromuscular disorders (NMDs) [1] is interesting but raises concerns.…”

“…Also their fourth, fifth, and sixth reference do not refer to patients with NMD. Thus, it is not clear from which cohort the 61 patients neurologically investigated for the actual study [1] were chosen, by which methods it was searched for NMDs in these patients, and who were the neurologists who performed the neurological investigations. It would be of particular interest from which type of myopathy the 14 patients with NMD were suffering.…”

“…Additionally, the authors state that only a small number of patients with NMD also present with increased creatine-kinase (CK) values [1]. In how many of their patients did they measure serum CK-values?…”

“…The experience we described in our article is an original contribution we meant to make to scientific knowledge and it was the result of our own work [1][2][3][4][5][6][7][8][9][10][11][12][13].…”