Neuromodulation of the peripheral nervous system: Bioelectronic technology and prospective developments

Abstract

The peripheral nervous system (PNS) is a fascinatingly complex and crucial component of the human body, responsible for transmitting vital signals throughout the body's intricate network of nerves. Its efficient functioning is paramount to our health, with any dysfunction often resulting in serious medical conditions, including motor disorders, neurological diseases, and psychiatric disorders. Recent strides in science and technology have made neuromodulation of the PNS a promising avenue for addressing these health issues. Neuromodulation involves modifying nerve activity using a range of techniques, such as electrical, chemical, optical, and mechanical stimulation. Bioelectronics plays a critical role in this effort, allowing for precise, controlled, and sustained stimulation of the PNS. This paper provides an overview of the PNS, discusses the current state of neuromodulation devices, and presents emerging trends in the field, including advances in wireless power transfer and materials, that are shaping the future of neuromodulation.

Active Micro-Nano-Collaborative Bioelectronic Device for Advanced Electrophysiological Recording

“…In addition, the utilization of flexible and stretchable organic electronic materials, coupled with low-impedance and low-modulus conductive polymer electrodes, presents a viable approach to mitigate invasiveness in surgical procedures and record action potentials with a high signal-to-noise ratio. This device's multiplexing capabilities enable accurate neural localization [152][153][154]. The emergence of various devices further expands the scope of electrophysiologic recording applications, providing robust technological resources for the diagnosis and treatment of cardiovascular and neurological disorders.…”