Neuromodulation of the Cervical Dorsal Root Ganglion for Upper Extremity Complex Regional Pain Syndrome—Case Report

Electrical Stimulation of Dorsal Root Ganglion in the Context of Pain: A Systematic Review of In Vitro and In Vivo Animal Model Studies

“…Beneficial effects on pain‐related outcomes in animal studies are in line with results from preliminary studies on humans, which indicated that neurostimulation of DRG could be a promising therapy for various types of clinical pain . Stimulation of DRG has many advantages over traditional SCS, including ability to target specific painful body parts, and it requires lower stimulation energy .…”

The Efficacy and Safety of Dorsal Root Ganglion Stimulation as a Treatment for Neuropathic Pain: A Literature Review

“…According to our review initial responders can expect variable degrees of pain relief, on occasion extending up to 100% , but consistently averaging 70–80% . An important trend in the literature is for pain relief to decrease over time and the extent of this might be underappreciated due to attrition bias .…”

“…Garg and Danesh describe a case of CRPS in the distal upper extremity of a 43‐year‐old woman who underwent cervical SCS. The patient had scarring at the C5/C6 posterior epidural space, probably as a result of an anterior cervical discectomy and fusion (ACDF) she had undergone more than 10 years before.…”

“…Electrical stimulation of the DRG can reduce neuronal excitability and the idea that dorsal root ganglion stimulation (DRGS) may be directly treating pathological neurons makes it an alluring target. To date DRGS has been used to treat postherpetic neuralgia , phantom limb pain (PLP) , failed back surgery syndrome (FBSS) post herniorrhaphy groin pain , radicular pain , complex regional pain syndrome (CRPS) of the foot , knee and distal upper limb , postsurgical perineal pain , pelvic girdle pain , peripheral nerve injury following kidney surgery , pain following femoral vascular access , and pain following deep vein thrombosis (DVT) amongst other unpublished indications.…”

Neurophysiological Effects of Dorsal Root Ganglion Stimulation (DRGS) in Pain Processing at the Cortical Level

“…Morgalla et al reported 63.5% overall pain relief and improvement in BPI scores under DRGS in patients with post‐herniorraphy inguinal pain, which was sustained even after three years of observation . These successful rates of pain relief have been replicated in other more recent smaller case series as well as in some case reports . In our study, we had 74% mean pain reduction at one month and 70% at six‐month postsurgery.…”