Electrical Stimulation of Dorsal Root Ganglion in the Context of Pain: A Systematic Review of In Vitro and In Vivo Animal Model Studies

Vuka, Ivana; Vučić, Katarina; Repić, Tihana; Hamzić, Lejla Ferhatović; Sapunar, Damir; Puljak, Livia

doi:10.1111/ner.12722

Cited by 29 publications

(22 citation statements)

References 46 publications

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“…Continuous radiofrequency acts as an analgesic by damaging the nerve tissue and destroying the pain conduction pathway. Contrary, PRF regulates the nerve through pulse current stimulation and exerts long‐term analgesic effect, which acts as a kind of neuromodulation . Both, clinical and preclinical testing have suggested that PRF could be used to treat neuropathic pain.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Computed Tomography-Guided Pulsed Radiofrequency Modulation of Thoracic Dorsal Root Ganglion on Herpes Zoster Neuralgia

Ding

Hong

et al. 2019

Neuromodulation: Technology at the Neural Interface

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Computed Tomography-Guided Pulsed Radiofrequency Modulation of Thoracic Dorsal Root Ganglion on Herpes Zoster Neuralgia

Ding

Hong

et al. 2019

Neuromodulation: Technology at the Neural Interface

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“…The end result of electrical stimulation on the DRG neurons is to stabilize and decrease hyperexcitability (15). In addition, to our knowledge, all in vitro and in vivo animal studies have shown that DRG stimulation has positive effects on pain-related outcomes without causing any inflammation or DRG tissue damage and may actually be antiinflammatory (16,17).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and Safety of Dorsal Root Ganglion Stimulation for the Treatment of Chronic Pain: A Pooled Analysis

Huygen

Kallewaard

Nijhuis

et al. 2020

Neuromodulation: Technology at the Neural Interface

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Introduction Since it became available in the mid‐2010s, dorsal root ganglion (DRG) stimulation has become part of the armamentarium to treat chronic pain. To date, one randomized controlled trial, and several studies of moderate sample size and various etiologies have been published on this topic. We conducted a pooled analysis to investigate the generalizability of individual studies and to identify differences in outcome between chronic pain etiologic subgroups and/or pain location. Materials and Methods One prospective, randomized comparative trial and six prospective, single‐arm, observational studies were identified that met pre‐defined acceptance criteria. Pain scores and patient‐reported outcome (PRO) measures were weighted by study sample sizes and pooled. Safety data are reported in aggregate form. Results Our analysis included 217 patients with a permanent implant at 12‐month follow‐up. Analysis of pooled data showed an overall weighted mean pain score of 3.4, with 63% of patients reporting ≥50% pain relief. Effectiveness sub‐analyses in CRPS‐I, causalgia, and back pain resulted in a mean reduction in pain intensity of 4.9, 4.6, and 3.9 points, respectively. Our pooled analysis showed a pain score for primary affected region ranging from 1.7 (groin) to 3.0 (buttocks) and responder rates of 80% for foot and groin, 75% for leg, and 70% for back. A substantial improvement in all PROs was observed at 12 months. The most commonly reported procedural or device complications were pain at the IPG pocket site, lead fracture, lead migration, and infection. Conclusions DRG stimulation is an effective and safe therapy for various etiologies of chronic pain.

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“…This pain is severe in perhaps more than half of that population [ 1 , 2 ]. In humans, neuropathic pain is referred as an abnormal pain sensation that results from a lesion or disease affecting the somatosensory system; different animal models have been reproduced in preclinical studies [ 3 , 4 , 5 , 6 , 7 ]. Neuropathic pain is characterized by the appearance of spontaneous pain with manifestation of abnormal sensory symptoms [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Neuropathic pain is characterized by the appearance of spontaneous pain with manifestation of abnormal sensory symptoms [ 8 , 9 , 10 ]. Neuropathic pain can result from a stimulus (hyperalgesia or allodynia), or be independent of the stimulus; the pain is spontaneous and described as burning, firing, or throbbing [ 7 , 8 , 11 ]. The discharge of pain is triggered by the release of algogenic agents at the site of damage, as well as by the recruitment of primary afferent fibers releasing neuropeptides, including substance P. These neurochemical events form the basis of hyperalgesia, which can originate within the injured area (primary hyperalgesia) and at the surrounding tissues (secondary hyperalgesia).…”

Section: Introductionmentioning

confidence: 99%

Neuroimmune-Driven Neuropathic Pain Establishment: A Focus on Gender Differences

Coraggio

Guida

Boccella

et al. 2018

IJMS

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The role of neuroinflammatory cells in the establishment of neuropathic pain has been investigated in depth in the last few years. In particular, microglia have been shown to be key players in the induction of tactile allodynia, as they release proinflammatory molecules that, in turn, sensitize nociceptive neurons within the spinal cord. However, the role of peripheral immune cells such as macrophages, infiltrating monocytes, mast cells, and T-cells has been highlighted in the last few studies, even though the data are still conflicting and need to be clarified. Intriguingly, the central (microglia) and peripheral (T-cell)-adaptive immune cells that orchestrate maladaptive process-driven neuropathic pain seem to be involved in a gender-dependent manner. In this review, we highlight the role of the microglia and peripheral immune cells in chronic degenerative disease associated with neuro-immune-inflammatory processes.

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Electrical Stimulation of Dorsal Root Ganglion in the Context of Pain: A Systematic Review of In Vitro and In Vivo Animal Model Studies

Cited by 29 publications

References 46 publications

Efficacy and Safety of Computed Tomography-Guided Pulsed Radiofrequency Modulation of Thoracic Dorsal Root Ganglion on Herpes Zoster Neuralgia

Efficacy and Safety of Computed Tomography-Guided Pulsed Radiofrequency Modulation of Thoracic Dorsal Root Ganglion on Herpes Zoster Neuralgia

Effectiveness and Safety of Dorsal Root Ganglion Stimulation for the Treatment of Chronic Pain: A Pooled Analysis

Neuroimmune-Driven Neuropathic Pain Establishment: A Focus on Gender Differences

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